Research Article

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Peroxisome proliferator-activated receptor delta (PPAR-δ) is a transcription factor implicated in metabolism and inflammation. The +294T/C polymorphism in the PPAR-δ gene is associated with risk of coronary artery disease (CAD) in dyslipidemic women and hypercholesterolemic men. Whether this polymorphism influences the risk of CAD in the absence of dyslipidemia was not known, so we ... more

I. Jguirim-Souissi; A. Jelassi; Y. Hrira; M. Najah; A. Slimani; F. Addad; M. Hassine; K.B. Hamda; F. Maatouk; M. Rouis; M.N. Slimane
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Cattle; Gene; mutations; Polymorphism; Sequence; TNF-RII

Tumor necrosis factor receptor type II (TNF-RII) is a surface glycoprotein that can form a complex with TNF-α and participate in the body's immune response. Functions of TNF-RII are impaired in the pathogenesis of viral diseases. We analyzed sequences in the regulatory region of the TNF-RII gene in cattle. An attempt was also made to identify mutations that would have the greatest effect ... more

A. Stachura; E. Kaczmarczyk; B. Bojarojć-Nosowicz
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Coronary artery disease; Endothelial lipase; Gene; Polymorphism

A growing body of evidence suggests that the 584C/T polymorphism in the endothelial lipase (EL) gene contributes to the process of coronary artery disease (CAD). The present study aimed to reveal the potential relationship between the EL 584C/T gene polymorphism and early-onset CAD, CAD severity, and lipid levels in a Chinese Han population. Participants comprised 135 early-onset CAD ... more

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02/20/2014
Antioxidant; Inflammation; Mutation; Oxidative stress; Polymorphism; Small bowel

Celiac disease (CD) is a multifactorial, inflammatory small bowel disorder characterized by nutrient malabsorption resulting from mucosal damage, the latter induced by cereal products like barley, oat, and wheat. Oxidative stress has previously been reported to play an important role in the pathogenesis of CD. In the present study, we aimed to evaluate the frequency of polymorphisms that ... more

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COX-1; Gene; Polymorphism

Variation in the gene encoding cyclooxygenase-1 (COX-1) is involved in the process of aspirin resistance. This study investigated the genetic variations in the COX-1 gene. The 4 coding regions of the human COX-1 gene in 90 pediatric patients (median age of 6.5 months, 55% males) with cardiovascular anomalies were screened using DNA sequencing. Twenty coding-region variants causing amino ... more

I. Coskun; Y. Colkesen; F. Ayik; A. Berdeli; Y. Atay
06/01/2015
Arg389Gly; Gene; Heart failure; Meta-analysis; Polymorphism; β1 adrenergic receptor

Numerous studies have evaluated the association between Arg389Gly polymorphism in the β1 adrenergic receptor gene and heart failure risk. However, the specific association is still controversial. We performed a meta-analysis of all case-control studies that evaluated the association between Arg389Gly polymorphism and heart failure in humans. Studies were identified in the PubMed, Embase, ... more

S.T. Ma; W. Zhao; B. Liu; R.Y. Jia; C.J. Zhao; L.Q. Cui
05/22/2015
Gene; Mild cognitive impairment; Polymorphism; Thyroid hormone; Type 2 deiodinase; Uygur

We investigated type II deiodinase (DIO2) polymorphisms and serum thyroid hormone levels in subjects with mild cognitive impairment (MCI) in a Uygur population. We studied the DIO2 Thr92Ala (rs225014) and ORFa-Gly3Asp (rs12885300) polymorphisms of 129 unrelated MCI cases and 131 matched controls. All subjects were genotyped using SNaPshot SNP genotyping assays. Serum ... more

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Gene; Liver X receptor α; Polymorphism; Stroke

We examined the relationship between the liver X receptor α gene (LXRα) polymorphism and the susceptibility to stroke. We utilized the single fluorescent-labeled probe technique to detect the genotype of rs12221497 in the LXRα gene in 400 stroke patients and 400 healthy control subjects. The difference in genotype distribution between the 2 groups was analyzed using the ... more

J.S. Yang; J.J. Hao; S.S. Wang; Z.F. Zhu; Q. Fang; H. Bao; H.P. Zhang
01/15/2015
Gene; Liver X receptor a; Polymorphism; Stroke

We examined the relationship between the liver X receptor a gene (LXRα) rsl2221497 polymorphism and the susceptibility to ischemic stroke in a Chinese population. The polymerase chain reaction-restriction fragment length polymorphism technique was used to detect the genotype of rsl2221497 in the LXRαgene of 300 stroke patients and 300 healthy control ... more

H.X. Wang; K. Zhang; L. Zhao; J.W. Tang; L.Y. Gao; Z.P. Wei
02/10/2009
Apoptosis; DNA damage; genomic instability; Inflammation; Isocyanates; Lung cancer

Lungs comprise the primary organ exposed to environmental toxic chemicals, resulting in diverse respiratory ailments and other disorders, including carcinogenesis. Carcinogenesis is a multi-stage phenomenon, which involves a series of genetic alterations that begin with genomic instability provoked by certain factors such as inflammation and DNA damage and end with the development of cancer. ... more

P.K. Mishra; A. Bhargava; G.V. Raghuram; S. Gupta; S. Tiwari; R. Upadhyaya; S.K. Jain; K.K. Maudar

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