Research Article

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05/30/2014
Aberrant DNA methylation; Gastric cancer; hMLH1; MGMT

We aimed to explore the association between aberrant DNA methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) and human mutL homolog 1 (hMLH1) genes with gastric cancer. A total of 283 gastric cancer patients who were confirmed by pathological diagnosis were included in our study. Aberrant DNA methylation of MGMT and hMLH1 were detected. The proportions of ... more

J. Jin; L. Xie; C.H. Xie; Y.F. Zhou
05/09/2014
Colorectal cancer; Gastric cancer; Single nucleotide polymorphism; susceptibility

Evidence suggests that some genetic variants are risk factors for both colorectal cancer (CRC) and gastric cancer (GC). Thus, we selected 12 reported single nucleotide polymorphisms (SNPs) from genome-wide association studies of CRC and conducted this case-control study to assess the associations between these SNPs and the risk for GC in a southern Chinese population. All SNPs were ... more

C.P. Zhou; H.Z. Pan; F.X. Li; N.Y. Hu; M. Li; X.X. Yang
03/24/2014
Gastric cancer; Haplotype analysis; Methylenetetrahydrofolate reductase; susceptibility

Epidemiological studies have indicated that folate metabolism is correlated with increased risk of gastric cancer. Since methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, in this study, we examined whether polymorphisms and haplotypes of MTHFR are correlated with the risk of gastric cancer. The polymorphisms MTHFR C677T and ... more

J. Lin; R.M. Zeng; R.N. Li; W.H. Cao
03/06/2014
Chemotherapy; Gastric cancer; Meta-analysis; Polymorphism; XRCC1

It is still controversial whether X-ray repair cross-complementing group (XRCC1) gene polymorphisms (Arg194Trp and Arg399Gln) are associated with the clinical outcome of platinum-based chemotherapy in gastric cancer patients based on published studies. Meta-analysis was performed to provide a systematic review of the findings. Eligible articles from the PubMed, SinoMed, and CNKI ... more

J. Xu; J. Ma; H.T. Zong; S.Y. Wang; J.W. Zhou
06/29/2015
Enteral nutrition; Gastric cancer; High-sensitivity C-reactive protein; Parenteral nutrition; Prealbumin

We investigated the impact of early enteral nutrition (EEN) and parenteral nutrition (PN) on prealbumin (PA) and high-sensitivity C-reactive protein (hs-CRP) in patients after gastric cancer surgery. Sixty-eight selected patients undergoing gastric cancer surgery were randomly divided into the EEN (N = 34) and PN (N = 34) groups. Body weight (BW), serum albumin (ALB), transferrin (TF), ... more

B. Li; H.Y. Liu; S.H. Guo; P. Sun; F.M. Gong; B.Q. Jia
06/29/2015
Enteral nutrition; Gastric cancer; Immune function; Intestinal function; Nutritional status

The impact of early enteral nutrition (EEN) on clinical outcomes of gastric cancer patients was investigated. Three hundred pa­tients undergoing gastric cancer surgery from July 2010 to May 2014 were randomly divided into experimental and control groups (n = 150/group). Experimental group patients received enteral nutrition in water during the early postoperative period. Control group ... more

B. Li; H.Y. Liu; S.H. Guo; P. Sun; F.M. Gong; B.Q. Jia
06/26/2015
Gastric cancer; IL-17A; IL-17F; Polymorphism

We conducted a meta-analysis of eligible studies to estimate the association between gastric cancer risk and rs2275913G>A IL-17A and rs763780T>C IL-17F polymorphisms. We searched the relevant studies in both Chinese and English through PubMed, the Web of Science, the Cochrane Library, and EMBASE up to January 1, 2014, including 3939 cases and 5407 controls. Seven eligible case- ... more

Z. Li; Y. Liu; D. Cao; M. Jiang; F. Luo
06/10/2015
Enteral nutrition; Gastric cancer; Immune function; Preoperative

We studied the effects of enteral nutrition (EN) support initiated 1 week before surgery on postoperative nutritional status, immune function, and inflammatory response in gastric cancer patients. A total of 200 gastric cancer patients were randomly divided into two groups: EN starting 1 week before surgery (study group) and EN starting early after surgery (control group). The two groups ... more

F. Wang; M.X. Hou; X.L. Wu; L.D. Bao; P.D. Dong
05/18/2015
Angiogenesis; bFGF; c-Myc; Gastric cancer; Recombinant human endostatin; Tumor metastasis

The aim of this study was to observe the effects of re­combinant human endostatin on the proliferation and apoptosis of mouse gastric cancer cells, and explore some possible mechanisms of recom­binant human endostatin inhibition of cancer. A murine gastric cancer xenograft model was established. A total of 20 mice were divided into two groups (control and experimental groups). The ... more

Z.Y. Guo; G.D. Yao; L.P. Fu; Z.G. Fu; B. Hou
04/15/2015
Clinical efficacy; Gastric cancer; Laparoscopy

The purpose of this study is to compare the efficacy of laparoscopy-assisted radical gastrectomy (LARG) versus that of open radical gastrectomy (ORG). Clinical data of 355 patients who underwent radical gastrectomy (160 in the LARG group and 195 in the ORG group) were analyzed retrospectively. Efficacy indices were compared and analyzed between the two groups. The operating time of LARG ... more

L.M. Wu; X.J. Jiang; Q.F. Lin; C.X. Jian

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