Research Article

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07/24/2014
Liver cancer; Meta-analysis; MicroRNA; Single nucleotide polymorphism

MicroRNAs (miRNAs) are small non-coding RNA molecules that play a fundamental role in controlling a variety of biological functions. Emerging evidence has shown that common genetic polymorphisms in miRNAs may be associated with the development of liver cancer; however, several individually published studies showed inconclusive results. This meta-analysis aimed to derive a more precise ... more

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Asian; Hepatocellular carcinoma; Meta-analysis; Methylation; RUNX3

Runt-related transcription factor 3 (RUNX3) is a potential tumor suppressor that is frequently hypermethylated in hepatocellular carcinoma (HCC). The present meta-analysis of case-control studies was carried out to determine whether RUNX3 hypermethylation is associated with HCC. The PubMed, Embase, and Chinese National Knowledge Infrastructure databases were searched for ... more

X.X. Lu; L.Q. Zhu; F. Pang; W. Sun; C. Ou; Y. Li; J. Cao; Y.L. Hu
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Deep vein thrombosis; Meta-analysis; Randomized controlled trial; Thrombolysis

We performed a meta-analysis for systematic evaluation of the status quo of catheter thrombolysis for the treatment of acute lower limb deep vein thrombosis in China. We searched the China Biomedical bibliographic database (CBM), China National Knowledge Infrastructure (CNKI), Weipu full-text electronic journals, Wanfang full-text database, and Medline (1990 through June 2011) ... more

J.J. Zheng; Z.H. Zhang; Z. Shan; W.J. Wang; X.X. Li; S.M. Wang; Y.X. Li; G.S. Cheng
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Association study; Inflammatory bowel diseases; Meta-analysis; Polymorphism; Vitamin D receptor

The gene encoding vitamin D receptor (VDR) is recognized as a promising candidate for indicating the development of inflammatory bowel disease (IBD). Four genetic polymorphisms (ApaI, BsmI, FokI, TaqI) in VDR have been widely evaluated to determine their association with IBD, and the results of these evaluations are often inconsistent. ... more

L. Wang; Z.T. Wang; J.J. Hu; R. Fan; J. Zhou; J. Zhong
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Esophageal cancer; Insulin-like growth factor; Lung cancer; Meta-analysis; Polymorphism

Recent evidence suggests that genetic variations in the insulin-like growth factor (IGF)-IGF receptor (IGFR)-IGF binding proteins (IGFBP) axis may impact an individual’s susceptibility to lung and esophageal cancer, but individually published results are inconclusive. Our meta-analysis aimed at providing a more precise estimation of these associations. An extensive literature search was ... more

X.P. Huang; W.H. Zhou; Y.F. Zhang
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Chemotherapy; Gastric cancer; Meta-analysis; Polymorphism; XRCC1

It is still controversial whether X-ray repair cross-complementing group (XRCC1) gene polymorphisms (Arg194Trp and Arg399Gln) are associated with the clinical outcome of platinum-based chemotherapy in gastric cancer patients based on published studies. Meta-analysis was performed to provide a systematic review of the findings. Eligible articles from the PubMed, SinoMed, and CNKI ... more

J. Xu; J. Ma; H.T. Zong; S.Y. Wang; J.W. Zhou
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Coronary artery disease; Meta-analysis; PTGS2

Previous studies focusing on the association of PTGS2 polymorphism -765G>C with coronary artery disease (CAD) have failed to reach the same conclusion. In the present study, we performed a meta-analysis to systematically summarize the possible association between PTGS2 polymorphism -765G>C and the risk of CAD. We conducted a search of case-control studies on the ... more

C.L. Xuan; W. Yan; L. Xuan; R.H. Xu
02/28/2014
Asthma; IL-4; Meta-analysis; Polymorphisms; Promoter

This study aimed to more precisely assess the correlation between interleukin-4 (IL-4) promoter polymorphisms and the susceptibility risk of asthma. We conducted association studies on IL-4 promoter C-33T, C-589T, and G-1098T polymorphisms with asthma using data obtained from MEDLINE up to September 2011. Results showed that the polymorphisms IL-4 C-33T and C-589T were significantly ... more

L. Tang; H.G. Lin; B.F. Chen
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Diffuse gastric cancer; Epithelial cadherin; Genetic susceptibility; Meta-analysis; Polymorphism

Several previous studies have investigated whether the -160C/A epithelial cadherin promoter polymorphism confers an increased risk of diffuse gastric cancer (DGC), but conflicting results have been reported. To explore further the association of this polymorphism with DGC susceptibility, we performed an extensive search of relevant studies and conducted a meta-analysis to obtain a more ... more

X.W. Chen; J.X. Sun; Z.N. Wang; P. Gao; Y.X. Song; J.F. Cao; B. Liu; H.M. Xu
01/28/2014
EPHX1; Esophageal cancer; Meta-analysis; Polymorphism

Microsomal epoxide hydrolase 1 (EPHX1) is an important biological phase II metabolic enzyme that is extensively involved in the metabolism of diverse environmental carcinogens such as polycyclic aromatic hydrocarbons and heterocyclic amines. Many articles have reported the association between EPHX1 (Tyr113His and His139Arg) polymorphisms and esophageal cancer risk, but the results are ... more

X. Tan; W.W. He; Y.Y. Wang; L.J. Shi; M.W. Chen

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