Research Article

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Cardiovascular disease; Meta-analysis; Myocardial infarction; Visfatin

Visfatin, an adipocytokine involved in metabolic and immune disorders, plays an important role in the etiology of cardiovascular disease. Recent evidence has shown that an elevated plasma level of visfatin may increase the risk of myocardial infarction (MI), but individual published studies have shown inconclusive results. This study aimed to obtain a more precise estimate of the ... more

Y. Yang; Z. Li; H.F. Tao; X.Y. Qi; W.L. Wang; L. Yang; H. Wang; P. Xu
10/20/2014
Atrial fibrillation; KCNE1; Meta-analysis; Polymorphism; susceptibility

KCNE1, a membrane protein that spans the membrane once is responsible for modulating potassium channel functions and plays an important role in the etiology of arrhythmia. Emerging evidence indicates that a common polymorphism (112G>A; rs1805127 G>A) in the KCNE1 gene contributes to atrial fibrillation (AF) risk; however, these studies showed inconclusive results. In this ... more

H.G. Han; H.S. Wang; Z. Yin; H. Jiang; M. Fang; J. Han
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Angiotensin-converting enzyme; Association; Meta-analysis; Polymorphism; Systemic sclerosis

The purpose of this study was to examine whether the insertion (I) or deletion (D) polymorphism of the angiotensin-converting enzyme gene (ACE) is associated with susceptibility to systemic sclerosis (SSc). A meta-analysis examining the associations between the ACE I/D polymorphism and SSc was conducted in overall and European populations using 1) allelic contrast (D ... more

G.G. Song; Y.H. Lee
10/07/2014
EGF; Liver cancer; Meta-analysis; Meta-regression; Polymorphism

Emerging evidence suggests that a common functional polymorphism, rs4444903 (A>G), in the EGF gene might impact an individual’s susceptibility to liver cancer; however, individually published results are inconclusive. This meta-analysis aimed to derive a more precise estimation of the relationship between the EGF rs4444903 polymorphism and liver cancer risk. A ... more

Y.L. Li; Z. Tian; L. Zhao; C.L. Zhang
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Breast cancer; EPHX1; Lung cancer; Meta-analysis; Polymorphism

The association between the microsomal epoxide hydrolase 1 gene (EPHX1) Tyr113His polymorphism and lung cancer and breast cancer risk has been reported in many recent studies, but there is no consensus among the results. Thus, we examined the association between the EPHX1 Tyr113His polymorphism and lung cancer through a meta-analysis. A comprehensive literature search was ... more

X. Tan; Y.Y. Wang; X.Y. Chen; L. Xian; J.J. Guo; G.B. Liang; M.W. Chen
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Colorectal cancer; Diagnosis; Meta-analysis; NGAL; Prognosis

Growing evidence has implicated that neutrophil gelatinase-associated lipocalin (NGAL) plays a role in a spectrum of human cancers. Several observational studies from different parts of the world have been devoted to elucidate the clinical relationship between NGAL and colorectal cancer. This meta-analysis aimed to explore the overall accuracy of NGAL detection for the diagnosis and ... more

Y. Wang; T.T. Zeng
08/25/2014
ADAM33; COPD; Meta-analysis; Polymorphism

Numerous studies have evaluated the association between polymorphisms of a disintegrin and metalloproteinase 33 (ADAM33) gene and chronic obstructive pulmonary disease (COPD) risk; however, the results remain conflicting. The aim of this study was to investigate whether ADAM33S2 and -T1 polymorphisms are associated with susceptibility to COPD risk in the Chinese population. Publications ... more

D.D. Li; S.J. Guo; L.Q. Jia; F.Q. Wen
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Digestive cancer; Hypoxia inducible factor-1α; Meta-analysis; Polymorphism; susceptibility

Recent evidence suggests that common functional polymorphisms in the hypoxia inducible factor-1α (HIF-1α) gene may play an important role in the development and progression of digestive cancer, but individually published results are inconclusive. Our meta-analysis is aimed to derive a more precise estimation of the relationships between HIF-1αgene ... more

J.J. Xu; L.Y. Zou; L. Yang; X.L. He; M. Sun
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Diabetes mellitus; Genetic polymorphisms; HNF1β; Meta-analysis; Prostate cancer

Polymorphism 17q12 rs4430796 within HNF1βis a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findings, therefore, we carried out a meta-analysis by pooling the ... more

Y.Z. Xiang; S.B. Jiang; J. Zhao; H. Xiong; Z.L. Cui; G.B. Li; X.B. Jin
07/25/2014
Digestive tract cancer; Hypoxia inducible factor-1α; Meta-analysis; Polymorphism

Many existing studies have demonstrated that common polymorphisms in the hypoxia inducible factor-1α (HIF-1A) may contribute to the development of digestive tract cancers, but individually published studies showed inconclusive results. This meta-analysis aimed to derive a precise estimation of the relationships between HIF1A Pro582Ser polymorphism and the risk of ... more

J. Xu; L. Xu; L.T. Li; Q. You; L.S. Cha

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