Research Article

Related GMR Articles

CYP1A2; Drug-induced liver injury; Gene polymorphism; Polygonum multiflorum

The objective of this study was to evaluate the genotype and allelic frequencies of CYP1A2 in Chinese patients with acute liver injury induced by Polygonum multiflorum. We examined the clinical mechanism of acute liver injury induced by P. multiflorum. According to the diagnostic criteria for drug-induced liver injury (DILI), 43 cases of P. ... more

K.F. Ma; X.G. Zhang; H.Y. Jia
Ankylosing spondylitis; Gene polymorphism; Tumor necrosis factor; Tumor necrosis factor receptor

We aimed to explore the association between the onset of ankylosing spondylitis (AS) and nt587 polymorphisms of the tumor necrosis factor receptor II (TNFRII) gene in the Han population of Hunan Province, China. Correlation analysis was performed in a case-control study involving 100 AS cases and 100 healthy controls. The nt587 single nucleotide polymorphism of the TNFRII gene was ... more

X. Li; M. Wang; R. Ma; T. Zhang; J. Liu; J.W. Chen; W. Peng
Gene polymorphism; Killer cell immunoglobulin-like receptor; Polymerase chain reaction sequence-specific primers; Uygur

We analyzed killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and genotype and haplotype characteristics in the Uygur population, a non-nomadic ethnic group found in Xinjiang, China, to provide a basis for studies on relationships between KIRs and diseases in this group. Sequence-specific primer PCR was used to detect the KIR gene in 84 Uygur ... more

G.Y. Lin; Y.B. Wang
Coronary artery disease; Gene polymorphism; MKL1

We investigated genetic susceptibility to coronary artery disease (CAD) by studying the association of MKL1 gene polymorphisms with CAD in the Chinese Han population. We performed a case-control study with 476 unrelated CAD patients and 325 non-CAD controls. All SNPs were genotyped with a TaqMan SNP genotyping assay. The distribution of MKL1-184C>T gene polymorphism in each group was ... more

Y. Xu; B. Li; Y.Z. Bao; X.Y. Zhang; Z.Y. Zhu; X.F. Zhao; Y.N. Shi; D. Li; S.H. Chen; Y. Guo; C.H. Cui
Carotid atherosclerosis; Gene polymorphism; Human platelet alloantigen; Type 2 diabetes mellitus

We investigated the association between the polymorphism of human platelet alloantigen genes HPA-1-HPA-5 and the complication of type 2 diabetes mellitus (T2DM) by carotid atherosclerosis (CA) among Han people in Guiyang District, China. Ninety-nine T2DM patients were selected from the Affiliated Hospital of Guiyang Medical College and divided into a CA(+) group and a CA(-) group ... more

Y.H. Zhang; S.F. Xu; J. Zheng; H.S. Hong; L.M. Fan
Gene polymorphism; Menstrual disorder; PNPLA7 gene; Susceptibility; Type O blood

We examined the correlation between PNPLA7 gene polymorphisms at the rs61754920 and rs11137410 loci and menstrual disorder in women of reproductive age in the Central Plain. Genomic DNA was extracted from peripheral blood; polymerase chain reaction-ligase detection reaction and SNaPshot genotyping were used to detect polymorphisms in the rs61754920 and rs11137410 gene loci, ... more

Y. Su; G.L. Kong; Y.L. Su; Y. Zhou; L.F. Lv; Q. Wang; B.P. Huang; R.Z. Zheng; Q.Z. Li; H.J. Yuan; Z.G. Zhao