Research Article

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Carotid artery intima-media thickness; Hypertension; Serum sulfatide

Hypertension is a major traditional risk factor for atherosclerosis, and carotid artery intima-media thickness (IMT) is considered to be an important marker of atherosclerosis. Sulfatides have been shown to play a role in atherogenesis and vascular inflammation, resulting in atherosclerosis. This study aimed to assess the association between serum sulfatide and carotid artery IMT among ... more

G. Li; R. Hu; J. Gu; H.Z. Wu
09/21/2015
c-Jun N-terminal kinases; CAAT/enhanced I-binding protein; Endoplasmic reticulum stress; Hypertension; Ischemia/reperfusion

Acute brain ischemia can induce the activation of c-Jun N-terminal kinases (JNKs). Hypertension is a critical etiology for brain ischemia. We identified the effects of hypertension on the activation of JNK as well as its impact on SP600125, a JNK inhibitor, during endoplasmic reticulum stress (ERS) in the hippocampus using a rat model. Transient whole-brain ischemia was induced by 4- ... more

Y.N. Zhao; J.M. Li; C.X. Chen; P. Zhang; S.X. Li
08/21/2015
Haplotype; Hypertension; Mongolian; SLC12A3; TagSNP

Mounting evidence has implicated the SLC12A3 gene in essential hypertension. Here, we examined the potential associations of common variants of the SLC12A3 gene with blood pressure traits in Mongolians in China. Genomic DNA was extracted from 508 unrelated Mongolian patients with essential hypertension and 246 normotensive Mongolian subjects for genotyping. The genotype ... more

J.Q. Liang; Y.G. Xi; C.Y. An; X.L. Su
08/03/2010
Chinese Han population; Rheumatoid arthritis; Single-nucleotide polymorphism; Suppressor of cytokine signaling-3 (SOCS-3)

Suppressor of cytokine signaling (SOCS)-3 is a key negative regulator of cytokine signaling that inhibits the JAK/STAT signal transduction pathway; there are reports describing its role in attenuating arthritis through SOCS-3 overexpression. We examined the relationship between polymorphisms in the coding sequence and promoter region of SOCS-3 and rheumatoid arthritis (RA) in a ... more

L.P. Sun; X.L. Ma; H.X. Liu; Y.S. Wang; X.F. Li
12/09/2008
Multidrug resistance; multidrug resistance protein; Single nucleotide polymorphism

One of the main problems in treating cancer patients is that cancer cells can develop drug resistance. Resistance to multiple anticancer drugs, so called multidrug resistance (MDR), most likely involves a nonspecific mode of resistance, through drug-efflux transporters. One of the most extensively studied genes involved in MDR is multidrug resistance protein 1 (MRP1). We investigated ... more

F. Mahjoubi; S. Akbari; M. Montazeri; F. Moshyri
12/14/2011
Carcass traits; quantitative trait locus; Single nucleotide polymorphism; Sus scrofa chromosome 7 (SSC7)

Many QTLs for fatness traits have been mapped on pig chromosome 7q1.1-1.4 in various pig resource populations. Eight novel markers, including seven SNPs and one insertion or deletion within BTNL1, COL21A1, PPARD, GLP1R, MDFI, GNMT, ABCC10, and PLA2G7 genes, as well as two previously reported SNPs in SLC39A7 and ... more

W.H. Huang; Z.X. Ma; Z.Y. Xu; Y.Z. Xiong; B. Zuo
09/27/2011
Allelic frequencies; meat quality; Myogenic determination gene 1; Qinchuan cattle; Single nucleotide polymorphism

The myogenic determination 1 (MyoD1) gene is a member of the MyoD gene family. It encodes for skeletal muscle-specific transcription factors containing highly conserved basic helix-loop-helix regions that perform important roles in the initiation, maintenance, and regulation of phenotypic traits. We investigated a new single nucleotide polymorphism (SNP) in the MyoD1 gene to evaluate ... more

J.A. Ujan; L.S. Zan; H.B. Wang; S.A. Ujan; C. Adoligbe; H.C. Wang; S.F. Biao
08/26/2011
Dairy cattle; Fertility; Growth hormone; IGF-1; Single nucleotide polymorphism

The somatotrophic axis (GH-IGF) is a key regulator of animal growth and development, affecting performance traits that include milk production, growth rate, body composition, and fertility. The aim of this study was to quantify the association of previously identified SNPs in bovine growth hormone (GH1) and insulin-like growth factor 1 (IGF-1) genes with direct ... more

M.P. Mullen; C.O. Lynch; S.M. Waters; D.J. Howard; P. O’Boyle; D.A. Kenny; F. Buckley; B. Horan; M.G. Diskin
08/26/2011
Cathechol-o-methyltransferase; Dopamine D3 receptor; Polymerase chain reaction; Restriction fragment length polymorphism; Schizophrenia; Single nucleotide polymorphism

Molecular components of the dopamine D3 receptor (DRD3) may play an important role in the pathophysiology of schizophrenia. Previous studies have demonstrated an association between DRD3 Ser9Gly and cathechol-o-methyltransferase (COMT, SNP = rs165656) polymorphisms and schizophrenia but the results were inconclusive. We investigated this apparent association between Ser9Gly (A/G) ... more

S.F. Tee; P.Y. Tang; H.C. Loh
05/17/2011
Essential hypertension; Mongolian population; Single nucleotide polymorphism; TSC

We investigated a possible association between genetic variations in the thiazide-sensitive Na-Cl cotransporter (TSC) gene and essential hypertension (EH) in the Mongolian and Han ethnic groups in Inner Mongolia. Our study included 385 unrelated Mongolian herdsmen and 523 Han farmers. Nine tagSNPs of TSC were identified from the Chinese HapMap database based on pairwise ... more

P.Y. Chang; L.G. Zhao; X.L. Su

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