Research Article

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02/02/2015
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We investigated the association between polymorphisms in interleukin-10 (IL-10) -1082G/A (rs1800896), -819T/C (rs1800871), and -592A/C (rs1800872) and the risk of acute myeloid leukemia (AML) in a Chinese population. A total of 167 primary AML cases and 328 healthy control subjects were recruited at the First People’s Hospital of Yunnan Province between March 2009 and January ... more

C. Fei; X.M. Yao; Y. Sun; X.Z. Gu; L.Q. Yu; X. Lai
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Gestational diabetes; Macrophage migration inhibitory factor; Polymorphism; rs1007888; Single-nucleotide polymorphism

We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and the genetic susceptibility to gestational diabetes mellitus (GDM). A total of 240 GDM pregnant women (GDM group) and 330 healthy pregnant women (control group) were included in the study. Differences in the MIF rs1007888 genotype and allele ... more

Y. Zhan; C. Li; J. Chen; S. Yu; Q. Gao; Y.P. Wang; S.G. Liu
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Insulin resistance; Meta-analysis; Obesity; Polymorphism; TNF-α

Tumor necrosis factor-α (TNF-α) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. However, results obtained so far are quite conf‍‍licting. We therefore performed a meta-analysis to address this issue, basing on 17 studies from electronic databases (MEDLINE and EMBASE). No evidence of ... more

H.G. Wang; J. Yang; H. Han; F. Xu; Y. Bian; H. Zhang; J.L. Wang
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Fatty liver; L-FABP gene; Landes geese; Polymorphism; Tissue expression

Liver weight is an important economic trait in the fatty goose liver industry. Liver-type fatty acid binding protein (L-FABP) is involved in the formation and metabolism of fatty acids. Thus, we hypothesized that sequence polymorphisms in L-FABP were associated with fatty liver weight in goose. We first isolated, sequenced, and characterized the goose L-FABP gene, which ... more

Z. Song; D. Shao; X.X. Sun; J.W. Niu; D.Q. Gong
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Microsatellites; Polymorphism; Sinonovacula constricta

The razor clam, Sinonovacula constricta, is an important commercial bivalve and a popular mollusca food in China. Twelve polymorphic microsatellite markers were isolated from the razor clam using a partial genomic library enriched for tandem repeat sequences of (CA)16, (GA)16. Polymorphisms of these loci were evaluated in a wild population of 30 individuals ... more

H.T. Ma; H.B. Jiang; X.Q. Liu; X.P. Wu; X.M. Wei
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Gene; Liver X receptor a; Polymorphism; Stroke

We examined the relationship between the liver X receptor a gene (LXRα) rsl2221497 polymorphism and the susceptibility to ischemic stroke in a Chinese population. The polymerase chain reaction-restriction fragment length polymorphism technique was used to detect the genotype of rsl2221497 in the LXRαgene of 300 stroke patients and 300 healthy control ... more

H.X. Wang; K. Zhang; L. Zhao; J.W. Tang; L.Y. Gao; Z.P. Wei
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Candidate genes; Cattle; DGAT1; PCR-RFLP; Zebu

Recent reports identified DGAT1 (EC 2.3.1.20) harboring a lysine to alanine substitution (K232A) as a candidate gene with a strong effect on milk production traits. Our objective was to estimate the frequency of the DGAT1 K232A polymorphism in the main Zebu and Taurine breeds in Brazil as well as in Zebu x Taurine crossbreds as a potential QTL for marker-assisted selection ... more

G.A. Lacorte; M.A. Machado; M.L. Martinez; A.L. Campos; R.P. Maciel; R.S. Verneque; R.L. Teodoro; M.G.C.D. Peixoto; M.R.S. Carvalho; C.G. Fonseca
08/18/2009
Candidate gene; Genotyping; PCR-RFLP; POU1F

We examined the polymorphisms in the PIT1 gene of 103 pigs and compared their frequencies in the maternal and paternal lineages of the Pietrain and Large White breeds, which have undergone divergent selection for over 30 years. DNA samples extracted from the blood of these animals were amplified by PCR and genotyped by RFLP, using the restriction enzyme RsaI. The data were ... more

A.C.P. Silveira; T.F. Braga; J.F. Almeida; R.C. Antunes; P.F.A. Freitas; A.S.M. César; A.S.M. César; E.C. Guimarães
10/28/2008
12S/16S gene; gene variation; Microchiroptera; PCR-RFLP; RAG2 gene

A PCR-RFLP analysis of the restriction pattern in nuclear (RAG2) and mitochondrial (12S/16S) gene sequences of bat species from the Molossidae, Phyllostomidae, Vespertilionidae, and Emballonuridae families produced a large number of fragments: 107 for RAG2 and 155 for 12S/16S combined in 139 and 402 haplotypes, respectively. The values detected for gene variation were low for both sequences (0 ... more

S.R.C. Marchesin; M.R. Beguelini; K.C. Faria; P.R.L. Moreira; E. Morielle-Versute
10/31/2011
Melanocytes; Oxidative stress catalase gene (CAT); PCR-RFLP; Vitiligo

Accumulation of hydrogen peroxide (H2O2) and low catalase (CAT) activity have been demonstrated in the epidermis of vitiligo patients. We investigated a possible association between the CAT exon 9 (Asp-389) gene and vitiligo susceptibility in the Turkish population. Thirty-four patients with vitiligo and 49 gender, age and ethnic matched controls were ... more

H. Bulut; M. Pehlivan; S. Alper; A.G. Tomatir; H. Onay; S.E. Yüksel; F. Özkinay; S. Pehlivan

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