Research Article

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04/22/2015
Chemokine receptor 2; Monocyte chemoattractant protein 1; Non-small cell lung carcinoma; Polymorphism

Lung cancer is a common malignant tumor worldwide and is now the leading cause of cancer-related deaths. Monocyte chemoattractant protein 1 (MCP-1) and its receptor chemokine receptor 2 (CCR-2) are important chemokines. We examined the polymorphisms of 338 unrelated patients with non-small cell lung carcinoma (NSCLC) and 200 unrelated healthy controls of Han nationality in Northern China ... more

L. Yang; J. Wang; F.G. Li; M. Han; X.J. Chang; Z.T. Wang
04/17/2015
Brain metastasis; Non-small cell lung cancer; Polymorphism; TGFB1

We conducted a case-control study to investigate the role of 3 single-nucleotide polymorphisms of the gene encoding transforming growth factor-b1 (TGFB1) in the development of metastatic brain tumors in non-small cell lung cancer patients. The polymorphisms in TGFB1 rs4803455, rs1800469, and rs1800470 were evaluated by polymerase chain reaction-restriction fragment ... more

H.B. Wang; W.G. Song; H.Q. Liu; F. Fang; Y. Xiao
04/17/2015
Chronic obstructive pulmonary disease; Polymorphism; Vitamin D-binding protein

Vitamin D-binding protein (DBP), a highly polymorphic serum protein, encoded by GC gene, is important in the development of chronic obstructive pulmonary disease (COPD). This meta-analysis was performed to assess the association between GC polymorphisms (1F, 1S, and 2 alleles) and COPD susceptibility. Published case-control studies were retrieved from the Pubmed, Embase, and China ... more

M. Xiao; T. Wang; T. Zhu; F. Wen
04/22/2015
Meta-analysis; Methylenetetrahydrofolate reductase; Polymorphism; Psoriasis

Previous studies investigating the association between methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms and psoriasis risk have reported inconsistent results. The present meta-analysis aimed to comprehensively evaluate the association between MTHFR 677C/T polymorphism and psoriasis risk. The studies regarding the association between MTHFR 677C/T ... more

J.H. Qi; N. Shi; Y.J. Chen; G. Nie
04/17/2015
Angiotensin-converting enzyme; Meta-analysis; Polymorphism; Sarcoidosis

Previous reports identified an association between sarcoidosis and an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme. Our meta-analysis of articles published between March 1996 and June 2013 identified studies in the PubMed, EMBASE, and the China National Knowledge Infrastructure databases. We examined whether angiotensin-converting enzyme polymorphisms influence ... more

R. Zhu; L.Q. Bi; H. Kong; S.L. Tilley; H. Wang; W.P. Xie
04/15/2015
Colorectal cancer; IGFBP-3; Meta-analysis; Meta-regression; Polymorphism

Recent evidence suggests that genetic variations in the IGFBP-3 gene may impact susceptibility to colorectal cancer, but individually published results are inconclusive. Our meta-analysis was aimed at providing a more precise estimation of these associations. An extensive literature search was conducted for appropriate articles published before May 1, 2013. This meta-analysis was ... more

J. Xu; L. Xu; L.T. Li; Q. You; L.S. Cha
04/10/2015
Coronary artery disease; Interleukin-6; Polymorphism

We conducted a case-control study to investigate the association between IL-6 -174 G>C and -572 C>G polymorphisms and the risk of coronary artery disease (CAD). We genotyped IL-6 ˗174 G>C and -572 C>G in 402 patients with CAD and 402 control individuals. IL-6 -174 G>C (rs1800795) and -572 C>G (rs1800796) alleles were detected by polymerase chain ... more

K. Wang; P.S. Dong; H.F. Zhang; Z.J. Li; X.M. Yang; H. Liu
04/10/2015
Hanwoo cattle; IGF1 concentration; Polymorphism

In this study, we investigated the associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle. Polymerase chain reaction primers were based on GenBank accession No. AF404761 and amplified approximately 533-bp segments. Newly identified sequences were submitted to GenBank ... more

H.Y. Chung; Y.J. Choi; H.N. Park; M.E. Davis
03/31/2015
Asthma; Meta-analysis; Polymorphism; Single nucleotide polymorphism

The IL-4R Q576R polymorphism has been reported to increase susceptibility to asthma, but the results are controversial. Thus, we performed a meta-analysis to evaluate the association of the IL-4R Q576R polymorphism and asthma risk in the Chinese Han population. A total of sixteen eligible case-control studies that evaluated the relationship between the IL-4R ... more

Z.Y. Huang; B.J. Cheng; G.J. Cai; B.F. Zhang
03/31/2015
ERCC1; ERCC2; Glioma; Polymorphism

Several studies have examined the association between excision repair cross-complementation group 1 (ERCC1) C8092A and ERCC2 Lys751Gln polymorphisms and glioma risk, but the results have been inconclusive. We conducted a meta-analysis of 12 studies to determine the association between ERCC1 rs3212986 and ERCC2 rs13181 genes and glioma susceptibility. We searched for relevant studies in ... more

C.X. Zhou; J.H. Zhao

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