Research Article

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03/08/2012
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The etiology of gallstone disease is multifactorial; supersaturation of bile with cholesterol is a primary cause for gallstone formation. In previous studies, we found that fibroblast growth factor receptor 4 (FGFR4) plays an important role in maintaining bile acid homeostasis by regulating the expression of cholesterol 7α-hydroxylase (CYP7A1), a rate-limiting enzyme for bile acid ... more

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Cyclina sinensis; Genetic diversity; Microsatellite; Polymorphism

The Venus clam, Cyclina sinensis, is one of the most important bivalves in China marine aquaculture. Using (CA)15-enriched genomic libraries of this species, nine novel polymorphic microsatellite loci were isolated and characterized. The mean number of observed alleles per locus was 16 (range 8-24). The observed and expected heterozygosity ranged from 0.119 to 0.872 ... more

J.X. Wang; T.J. Xu; L. Wei; F.X. Meng; R.X. Wang
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Astrocytoma; Glioblastoma; Polymorphism; XRCC3

The gene XRCC3 (X-ray cross complementing group 3) has the task of repairing damage that occurs when there is recombination between homologous chromosomes. Repair of recombination between homologous chromosomes plays an important role in maintaining genome integrity, although it is known that double-strand breaks are the main inducers of chromosomal aberrations. Changes in the XRCC3 ... more

A.C. Custódio; L.O. Almeida; G.R. Pinto; M.J. Santos; J.R.W. Almeida; C.A. Clara; J.A. Rey; C. Casartelli
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Diabetes mellitus; Hypertension; Polymorphism; RT-qPCR; VDR gene

RT-qPCR was used to analyze the vitamin D receptor (VDR) gene TaqI polymorphism in 100 Turkish patients with type 2 diabetes mellitus (T2DM) and hypertension compared with 100 healthy subjects, to determine whether VDR could be considered as one of the susceptibility genes for T2DM and hypertension. Genotyping was done with PCR, followed by melting curve analysis with specific fluorescent ... more

H.C. Vural; E. Maltas
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Chinese Hui population; Haplotype; Polymorphism; Rheumatoid arthritis; TIM-1

The T-cell immunoglobulin and mucin domain 1 (TIM-1) is known to be associated with susceptibility to rheumatoid arthritis (RA). We investigated the association of four single-nucleotide polymorphisms (SNPs) in the promoter region of the TIM-1 gene with susceptibility to RA in a Chinese Hui ethnic minority group. Using RFLP or sequence specific primer-PCR, 118 RA patients and 118 non- ... more

J.R. Xu; Y. Yang; X.M. Liu; J.Y. Sun; Y.J. Wang
12/18/2014
Biochemical recurrence; miR-146a; Polymorphism; Prostate cancer

Evidence has shown that miR-146a is involved in carcinogenesis and a common G/C variant (rs2910164) in the pre-miR-146a gene has been found to be associated with various cancers. We investigated the potential prognostic role of miR-146a polymorphism in prostate cancer after radical prostatectomy. Seventy-two southern Chinese with prostate cancer undergoing radical prostatectomy were ... more

M. Chen; Z.Y. Zhou; J.G. Chen; N. Tong; S.Q. Chen; Y. Yang; X.W. Zhang; H. Jiang; N. Liu; J. Liu; G.Z. Sha; W.D. Zhu; L.X. Hua; Z.J. Wang; B. Xu
12/04/2014
Alzheimer’s disease; Meta-analysis; MicroRNA; Oxidized low density lipoprotein receptor 1; Polymorphism

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that contributes to dementia in the elderly population. Genome-wide linkage analysis has identified chromosome 12p as the AD-susceptible region, which includes lectin-like oxidized low-density lipoprotein receptor 1 (OLR1). The OLR1 +1073 C/T single-nucleotide polymorphism is located in the 3'- ... more

Y. Kong; J.B. Wu; X. Wang; J.F. Zhao; H. Song; L.D. Yuan
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Meta-analysis; Microsomal transfer protein; Non-alcoholic fatty liver disease; Polymorphism

Several studies have found that microsomal transfer protein (MTP) may be important in the development and progression of non-alcoholic fatty liver disease (NAFLD). In this meta-analysis, we evaluated the relationships between a common polymorphism (-493G>T, rs1800591 G>T) in the MTP gene and NAFLD risk. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, ... more

L. Li; S.J. Wang; K. Shi; D. Chen; H. Jia; J. Zhu
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Amplified fragment length polymorphism marker; Male sterile lines; Polymorphism; Triticum aestivum

To investigate the polymorphism of two groups of male sterile lines and their maintainer lines, we used amplified fragment length polymorphism markers. Of the 64 primer pairs, five reproducibly demonstrated polymorphism. Group I had 27 polymorphic bands, and Group II had 24 polymorphic bands. The maximum number of polymorphic bands was produced by line 2 (18 polymorphic bands) followed by ... more

M. Ejaz; Z. Gaisheng; Z. Quidi; W. Qunzhu; Z. Huiyan
12/04/2014
CYP1A1; CYP1A1m1; Glaucoma; Polymorphism; Primary open-angle glaucoma; Restriction fragment length polymorphism

The CYP1A1 gene is related to the generation of secondary metabolites that are capable of inducing DNA damage. The CYP1A1m1 polymorphism has been examined in many studies, and is located in a region near loci that have been linked to glaucoma, including the locus GLC1I. As a result, this polymorphism has been related to several diseases that are influenced by ... more

N.B. Costa; C.T.X. Silva; A.B. Frare; R.E. Silva; K.K.V.O. Moura

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