Research Article

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08/29/2014
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Diabetes mellitus; Genetic polymorphisms; HNF1β; Meta-analysis; Prostate cancer

Polymorphism 17q12 rs4430796 within HNF1βis a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findings, therefore, we carried out a meta-analysis by pooling the ... more

Y.Z. Xiang; S.B. Jiang; J. Zhao; H. Xiong; Z.L. Cui; G.B. Li; X.B. Jin
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Genetic polymorphisms; Myocardial infarction; Serum amyloid A

Previous studies suggested that genetic polymorphisms of serum amyloid A (SAA) were associated with carotid atherosclerosis. However, the relationship between genetic polymorphisms of SAA and myocardial infarction (MI) remains unclear. In the present study, we analyzed a polymorphism (rs12218) in the SAA1 gene in 840 MI patients and 840 healthy subjects by polymerase chain ... more

B.Y. Wang; J.Y. Hang; Y. Zhong; S.J. Tan
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Cytidine deaminase; Genetic polymorphisms; Lung cancer; Xeroderma pigmentosum complementary group D

Xeroderma pigmentosum group D (XPD) plays a key role in the repair of DNA and platinum resistance lesions. Cytidine deaminase (CDA) genes determine the velocity of gemcitabine catalysis. This study aimed to investigate the relationship between XPD and CDA genotypes and outcome in non-small lung cancer (NSCLC) patients. We used polymerase chain reaction-restriction fragment length ... more

M. Zhou; Y.J. Ding; Y. Feng; Q.R. Zhang; Y. Xiang; H.Y. Wan
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Essential hypertension; Evironmental risks; Feature selection; Genetic polymorphisms; Support vector machines

Statistical modeling of links between genetic profiles with environmental and clinical data to aid in medical diagnosis is a challenge. Here, we present a computational approach for rapidly selecting important clinical data to assist in medical decisions based on personalized genetic profiles. What could take hours or days of computing is available on-the-fly, making this strategy ... more

P.C. Carvalho; S.S. Freitas; A.B. Lima; M. Barros; I. Bittencourt; W. Degrave; I. Cordovil; R. Fonseca; M.G.C. Carvalho; R.S.Moura Neto; P.H. Cabello
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Amerindians; Brazilian population; DARC; DNA polymorphism; Duffy blood group; Genetic polymorphisms

Ala100Thr has been suggested to be a Caucasian genetic marker on the FY*B allele. As the Brazilian population has arisen from miscegenation among Portuguese, Africans, and Indians, this mutation could possibly be found in Euro- and Afro-Brazilians, or in Brazilian Indians. Fifty-three related individuals and a random sample of 100 subjects from the Brazilian population were investigated ... more

A.Cristina Estalote; R. Proto-Siqueira; W.Araújo Da Silva; M.Antonio Zago; M. Palatnik
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ABCB1 gene; Genetic polymorphisms; Infantile spasms

Infantile spasms are a severe epileptic encephalopathy with a variety of etiologies that occur in infancy and early childhood. Subjects with infantile spasms are at a higher risk for evolving into intractable epileptic spasms, tending to be refractory to conventional antiepileptic drugs. Genetic polymorphisms of the P-glycoprotein-encoding gene ABCB1 are suspected to be associated with ... more

L. Dong; M. Mao; R. Luo; Y. Tong; D. Yu
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Adenosine deaminase; Angiotensin-converting enzyme; Cardiovascular risk; Genetic polymorphisms; Type 2 diabetes mellitus
A.C.B. Domingos
09/19/2013
Association analysis; Genetic polymorphisms; susceptibility; Toll-like receptor 4; Type 2 diabetes mellitus

Toll-like receptor 4 (TLR4) is potentially an important gene affecting the susceptibility to type 2 diabetes mellitus (T2DM). The objective of this study was to evaluate whether genetic polymorphisms of the TLR4 gene are associated with T2DM susceptibility. This potential association was analyzed in 668 T2DM patients and 672 healthy controls by polymerase chain reaction- ... more

X.D. Fu; X.Q. Sun; H.Y. Wang; J.F. Guo; G.Z. Zhang; Q.H. Xu
09/19/2013
Elderly; FII G20210A; FV G1691A; Genetic polymorphisms; MTHFR C677T; Venous thromboembolism

Venous thromboembolism (VTE) is an important cause of morbidity and mortality stemming from cardiovascular disease. It is a multifactorial disease caused by a combination of acquired risk factors, of which advanced age is the most significant, and genetic factors, including the variants FV G1691A, FII G20210A, and MTHFR C677T. We estimated the prevalence of ... more

H. Ferreira-Fernandes; P.N. Costa; H.F. Fernandes; A.P. Araújo-Neto; F.J. Motta; R. Canalle; F.K. Yoshioka; J.F. Guerreiro; R.R. Burbano; J.A. Rey; G.R. Pinto

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