Research Article

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03/31/2015
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The IL-4R Q576R polymorphism has been reported to increase susceptibility to asthma, but the results are controversial. Thus, we performed a meta-analysis to evaluate the association of the IL-4R Q576R polymorphism and asthma risk in the Chinese Han population. A total of sixteen eligible case-control studies that evaluated the relationship between the IL-4R ... more

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ERCC1; ERCC2; Glioma; Polymorphism

Several studies have examined the association between excision repair cross-complementation group 1 (ERCC1) C8092A and ERCC2 Lys751Gln polymorphisms and glioma risk, but the results have been inconclusive. We conducted a meta-analysis of 12 studies to determine the association between ERCC1 rs3212986 and ERCC2 rs13181 genes and glioma susceptibility. We searched for relevant studies in ... more

C.X. Zhou; J.H. Zhao
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Cardiovascular events; Hemodialysis; IL-6; Polymorphism

We aimed to investigate the role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis. Blood samples were collected from 216 patients receiving hemodialysis treatment. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype IL-6 -634C/G, -174G/C and -572C/G. By ... more

Y. Song; H.D. Gu; Y. He; J.W. Wang
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Fatty acid synthase gene; Meat quality traits; Polymorphism; Yak

Fatty acid synthase (FASN) is a key enzyme in fatty acid anabolism that plays an important role in the fat deposit of eukaryotic cells. Therefore, in this study, we detected 2 novel single-nucleotide polymorphisms (SNPs) in the FASN gene in 313 adult individuals of Datong yak using polymerase chain reaction-single strand conformation polymorphism and DNA sequencing techniques. SNP ... more

M. Chu; X.Y. Wu; X. Guo; J. Pei; F. Jiao; H.T. Fang; C.N. Liang; X.Z. Ding; P.J. Bao; P. Yan
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Ischemic stroke; miR-149; Polymorphism

Clinical and experimental data have demonstrated that genetic factors play an important role in determining the susceptibility to ischemic stroke (IS). The present study was performed to clarify the association between the pre-microRNA-149 (miR-149) single nucleotide polymorphism rs71428439 and the risk of IS in the Jiangsu Han population. Polymerase chain reaction and restriction ... more

Q.Y. Chen; N. Liu; J. Ma; Y. Fang; Y. Cao; H. Li; Y.C. Liu
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Chinese; Metabolic syndrome; Obesity; Polymorphism; Type 2 diabetes

Metabolic syndrome (MetS) includes obesity, dyslipidemia, elevated blood pressure, and dysglycemia. Subjects with type 2 diabetes (T2D) exhibit features of MetS. The etiology of MetS is complex, involving both environmental and genetic factors. In this study, we examined the role of specific candidate genetic variants on the severity of MetS in T2D subjects. A total of 240 T2D subjects ... more

Y.L. Chen; D. Pei; Y.J. Hung; C.H. Lee; F.C. Hsiao; C.Z. Wu; J.D. Lin; C.H. Hsu; J.B. Chang; C.H. Hsieh
03/30/2015
All hermaphrodites; Phylogenetic analysis; Polymorphism; Simple sequence repeat

The papaya (Carica papaya L.) is one of the most important economic tropical fruits in the world, and the hermaphrodite is the preferred type in field cultures. We analyzed the sexual ratio of offspring from the cultivar ‘Taiwan Seed Station No. 7’ (T7) by a self-cross and its cross with Taichung Sunrise (TS). Female progeny from the T7 self-crossing were not observed. This ... more

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03/20/2015
Angiotensin-converting enzyme; Coronary artery disease; Polymorphism

We investigated whether the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and serum ACE levels are associated with traditional risk factors of coronary artery disease (CAD). We enrolled 250 individuals without CAD and 750 individuals suffering from CAD who were angiographically diagnosed. Biochemical risk factors, the ACE (I/D) gene ... more

S. Sahin; K. Ceyhan; I. Benli; H. Ozyurt; E. Naseri; M.M. Tumuklu; L. Aydogan; A.O. Elalmis; A.F. Ozugurlu; O. Onalan
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Osteosarcoma; Polymorphism; RECQL5

In this study, we investigated the association between a RECQL genetic polymorphism and osteosarcoma in a Chinese population. We selected rs820196 in the RECQL5 gene and genotyped 185 patients with osteosarcoma and 201 age- and gender-matched non-cancer controls. We found that the CC genotype was more frequent in the osteosarcoma group compared to the control group (P = ... more

Y.Z. Dong; Y.X. Huang; T. Lu
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EGFR; ERBB1; Gastric cancer; Polymorphism

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with tyrosine-kinase activity that plays an important role in multiple cellular functions. EGFR overexpression has been observed in several types of tumors and it is significantly associated with disease stage, survival, prognosis, and progression of cancer. The polymorphisms -216G>T, -191C>A, and (CA)n ... more

J.H. Torres-Jasso; M.E. Marín; E. Santiago-Luna; J.C. Leoner; J. Torres; M.T. Magaña-Torres; F.J. Perea; B. Ibarra; J.Y. Sánchez-López

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