Research Article

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06/11/2015
GSTT1; Neoplasia; Polymorphism; Pterygium

Pterygium is an inflammatory and degenerative ocular surface disease in which the conjunctiva on the cornea grows to form a fibrous tissue in the shape of a triangle. The disorder may be characterized by cell proliferation, inflammatory processes, fibrosis, angiogenesis, and destruction of the extracellular matrix. The anomaly is considered a degenerative eye disease and is erroneously ... more

G.Mdos Reis; deP.R. Júnior; K.S.Fe Silva; D.A. Rodrigues; M.C.S. Gomes; J.V.M. Martins; I.R. da Costa; G.A. Freitas; K.K.O. Moura
06/11/2015
GST; GSTM1; Polymorphism; Pterygium

The first reports about pterygium date back to Hip­pocrates, and this disease still threatens vision health around the world. Pterygium is a formation of fibrous tissue consisting of highly vascular­ized epithelial and subepithelial tissue that grows excessively and with an abnormal shape on the cornea. Many physical and biological factors are associated with the pathogenesis of pterygium ... more

deP.R. Júnior; G.Mdos Reis; K.S.Fe Silva; D.A. Rodrigues; M.C.S. Gomes; J.V.M. Martins; I.R. da Costa; G.A. Freitas; K.K.V.O. Moura
06/01/2015
Chinese bayberry; EST-SSR; Myrica rubra; Polymorphism; RNA-seq

Most plant expressed sequence tag-simple sequence repeats (EST-SSRs) are not polymorphic, and it is important to learn the characteristics of highly polymorphic EST-SSRs. In this study, 357 compound and 5557 non-compound EST-SSRs, identified from the transcriptome of the Chinese bayberry (Myrica rubra ‘Biqi’), were divided into 11 types based on their characteristics. ... more

S.Y. Zhang; C. Feng; C.J. Xu; C.Q. Zhu; K.S. Chen
05/29/2015
Cross-amplification; Microsatellite markers; Paramisgurnus dabryanus; Polymorphism

The large-scale loach, Paramisgurnus dabryanus, is a small freshwater fish of major economic importance in many Asian countries, particularly China and South Korea. Fifteen polymorphic microsatellite (simple sequence repeat) markers were obtained through cross-species amplification between this loach and a related species, Misgurnus anguillicaudatus (GenBank accession numbers: KC117456 to ... more

G. Chen; S. Huang; J. Gao; X. Bai; W. Wang; X. Cao
05/25/2015
Arctic fox; Leptin gene; Leptin receptor gene; Polymorphism; Production performance

The polymerase chain reaction-single-strand conforma­tion polymorphism technique was employed to measure mononucleo­tide diversity in the coding region of the leptin and leptin receptor genes in the Arctic fox. The relationships between specific genetic mutations and reproductive performance in Arctic foxes were determined to im­prove breeding strategies. We found that a leptin gene ... more

M. Zhang; X.J. Bai
05/25/2015
AGT; Essential hypertension; Meta-analysis; Polymorphism

Numerous studies have evaluated the association between the angiotensinogen (AGT) G-217A gene polymorphism and essential hypertension risk. However, the results have been inconsistent. We examined whether the AGT G-217A gene polymorphism confers essential hypertension risk by conducting a meta-analysis. We conducted a literature search of the Google Scholar, PubMed, and ... more

R. Yao; Y.Y. Du; Y.Z. Zhang; Q.H. Chen; L.S. Zhao; L. Li
05/25/2015
Meta-analysis; Polymorphism; Rheumatoid arthritis; Tumor necrosis factor; Vitiligo

We investigated whether the tumor necrosis factor-a (TNF-α) promoter -238 A/G and -308 A/G polymorphisms are associated with rheumatoid arthritis (RA) and vitiligo susceptibility. MEDLINE and EMBASE databases and a manual search were used to identify articles in which TNF-α polymorphisms were determined in RA or vitiligo patients and controls. Meta-analysis was used to ... more

Y.H. Lee; S.C. Bae
05/22/2015
Gene; Mild cognitive impairment; Polymorphism; Thyroid hormone; Type 2 deiodinase; Uygur

We investigated type II deiodinase (DIO2) polymorphisms and serum thyroid hormone levels in subjects with mild cognitive impairment (MCI) in a Uygur population. We studied the DIO2 Thr92Ala (rs225014) and ORFa-Gly3Asp (rs12885300) polymorphisms of 129 unrelated MCI cases and 131 matched controls. All subjects were genotyped using SNaPshot SNP genotyping assays. Serum ... more

M. Luo; X.H. Zhou; T. Zou; K. Keyim; L.M. Dong
05/22/2015
Carcass composition trait; Cattle; Growth trait; Meat quality trait; Polymorphism; Thyroglobulin gene

Thyroid hormones play an important role in regulating metabolism and can affect metabolism-related traits such as fat deposition. The thyroglobulin (TG) gene produces the precursor of thyroid hormones and has been proposed as a candidate gene for a quantitative trait locus with an effect on fat deposition. In this study, we identified 4 novel single nucleotide polymorphisms (SNPs ... more

L.P. Zhang; Q.F. Gan; G.Y. Hou; H.J. Gao; J.Y. Li; S.Z. Xu
05/18/2015
Chronic obstructive pulmonary disease; Meta-analysis; Polymorphism; Tumor necrosis factor-alpha

The association between the TNF-α +489 G/A polymorphism and chronic obstructive pulmonary disease (COPD) remains controversial because of small group size and varied design among different studies. In the present study, a meta-analysis was conducted to assess the association between the +489 G/A polymorphism and COPD risk. A comprehensive search was conducted to identify ... more

K. Cui; X.Y. Ge; H.L. Ma

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