Research Article

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08/31/2012
Cancer susceptibility; Gender; miR-146a; Polymorphism; Smoking

Evidence has shown that miR-146a is involved in carcinogenesis, and a common G/C variant (rs2910164) in the pre-miR-146a gene has been associated with various types of cancer. We summarized the data from 22 published case-control studies on the association between rs2910164 and cancer risk and performed subgroup analyses by ethnicity, gender and smoking status. We found a ... more

A.X. Wang; B. Xu; N. Tong; S.Q. Chen; Y. Yang; X.W. Zhang; H. Jiang; N. Liu; J. Liu; X.N. Hu; G.Z. Sha; M. Chen
09/13/2012
GSTM1; Polymorphism; Primary open-angle glaucoma

Primary open-angle glaucoma (POAG) is characterized by loss of retinal ganglion cells, optic nerve damage and irreversible loss of visual field. Glaucoma is the second leading cause of blindness worldwide. It was estimated that in 2010 there were about 60.5 million glaucoma cases worldwide; among these patients, 4.5 million will become bilaterally blind. Glutathione S-transferases (GST) ... more

A.M. Barbosa; A.B. Frare; N.B. Costa; R.E. Silva; K.K.V.O. Moura
08/29/2012
ANAPC13; Body measurement traits; Cattle; PCR-SSCP; Polymorphism

Body measurement traits, influenced by genes and environmental factors, play numerous important roles in the value assessment of productivity and economy. There has been some indication that ANAPC13 influences adult height. We used PCR-SSCP and DNA sequencing technology to identify polymorphisms in the ANAPC13 gene. A polymorphism in intron 1 (A > G at base 17) was identified and an ... more

B.J. Jiang; X.L. Zhan; C.Z. Fu; H.B. Wang; G. Cheng; L.S. Zan
08/06/2012
EST-SSRs; Molecular markers; Musella; Polymorphism; Transferability

We assembled 31,308 publicly available Musa EST sequences into 21,129 unigenes; 4944 of them contained 5416 SSR motifs. In all, 238 unigenes flanking SSRs were randomly selected for primer design and then tested for amplification in Musella lasiocarpa. Seventy-eight primer pairs were found to be transferable to this species, and 49 displayed polymorphism. A set of 34 ... more

W.J. Li; H. Ma; Z.H. Li; Y.M. Wan; X.X. Liu; C.L. Zhou
08/13/2012
Gastric cancer; Meta-analysis; NQO1 gene; Polymorphism; Risk

The association between the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and gastric cancer has been widely evaluated, yet with conflicting results. Data were available from seven study populations involving 2600 subjects. Overall, comparison of alleles 609T and 609C indicated a significantly increased risk (46%) for gastric cancer (95% confidence interval (95 ... more

Y. Zhang; Z.T. Wang; J. Zhong
07/19/2012
C-reactive protein; Inflammatory reaction; Intracerebral hemorrhage; Polymorphism; Resistin

We examined a possible relationship -420C>G SNP of the resistin gene with plasma resistin and C-reactive protein concentrations in intracerebral hemorrhage. Three hundred and forty-four Chinese Han patients with intracerebral hemorrhage and 344 age- and gender-matched healthy controls were included in our study. Plasma resistin and C-reactive concentrations were measured and SNP -420C ... more

X.Q. Dong; Q. Du; W.H. Yu; Z.Y. Zhang; Q. Zhu; Z.H. Che; H. Wang; J. Chen; S.B. Yang; J.F. Wen
05/14/2012
Microsatellite; Polymorphism; Taxus chinensis var. mairei

We isolated and characterized 11 microsatellite loci for the Chinese yew, Taxus chinensis var. mairei, an endangered tree species in China, by constructing a (CA)12-enriched library. The number of alleles per locus ranged from 5 to 10. The observed heterozygosities ranged from 0.2500 to 0.8333 and the expected heterozygosities ranged from 0.5196 to 0.8680. No ... more

H. Xue; C.H. Lu; X.B. Wu
05/15/2012
5p15; Polymorphism; Prostate cancer

Recent evidence has suggested that single-nucleotide polymorphisms (SNPs) located at 5p15.33 contribute to susceptibilities for several cancer types, including prostate cancer. To determine whether SNP rs402710 in this region plays a role in prostate cancer, we analyzed these associations in a Chinese population; 251 prostate cancer patients and 273 control subjects were included in this ... more

Q. Ren; B. Xu; S.Q. Chen; Y. Yang; C.Y. Wang; Y.D. Wang; X.H. Wang; L.X. Hua; M. Chen
05/15/2012
Killer cell immunoglobulin-like receptor; Polymorphism; Pulmonary tuberculosis; susceptibility

Killer cell immunoglobulin-like receptors (KIRs) are involved in the pathogenesis of a variety of diseases. However, whether KIR polymorphism is associated with susceptibility to pulmonary tuberculosis was unknown. We examined a possible association of KIR polymorphism with susceptibility to pulmonary tuberculosis in Chinese Han. We analyzed 15 KIR genes in 109 pulmonary tuberculosis ... more

C. Lu; Y.J. Shen; Y.F. Deng; C.Y. Wang; G. Fan; Y.Q. Liu; S.M. Zhao; B.C. Zhang; Y.R. Zhao; Z.E. Wang; C.Z. Zhang; Z.M. Lu
04/27/2012
Acetylating phenotype; NAT2; Polymorphism

The acetylating activity of N-acetyltransferase 2 (NAT2) has critical implications for therapeutics and disease susceptibility. To date, several polymorphisms that alter the enzymatic activity and/or protein stability of NAT2 have been identified. We examined the distribution and frequency of NAT2 genotypes in the Mexican population. Among 250 samples amplified and sequenced for ... more

L. Taja-Chayeb; J.A. Agúndez; C. Miguez-Muñoz; A. Chavez-Blanco; A. Dueñas-Gonzalez

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