Research Article

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Disease susceptibility; Innate immunity; Single-nucleotide polymorphisms; Toll-interleukin 1 receptor domain containing adaptor protein; Tuberculosis

Toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP; also known as MAL) is an essential adaptor molecule in Toll-like receptor signaling, involved in activating the innate immune response during infection. Genetic variations in the TIRAP gene may influence human susceptibility to infectious disease. To date, in the Chinese population, a possible ... more

Y.X. Zhang; Y. Xue; M.Y. Zhao; H.J. Wang; J.C. Li; J.Y. Liu; F.J. Li; J.M. Zhou
10/24/2013
Diagnosis; Pulmonary; Sputum; Surfactant protein-A; Tuberculosis

The aim of this study was to explore the diagnostic and differential diagnosis value of surfactant protein-A (SP-A) in the serum and sputum for pulmonary tuberculosis. A total of 101 patients with pulmonary tuberculosis, 85 healthy volunteers, and 30 chronic obstructive pulmonary disease (COPD) patients were divided into pulmonary tuberculosis group, healthy control group, and COPD group ... more

H. Hu; G.L. Teng; L.Z. Gai; Y. Yang; C.J. Zhu
08/24/2018
Ankylosing spondylitis; CD40 gene; Disease susceptibility; Gene polymorphism

Ankylosing spondylitis (AS) is a potentially disabling form of a systemic chronic inflammatory arthritis affecting mainly the axial skeleton, with or without extraspinal manifestations. The genetic basis of AS is partly known. Moreover, many autoimmunity-related genes have pleiotropic effects. Multiple functional polymorphisms in the genes encoding the tumor ... more

J. Zepa; L. Silamiķele; I. Bulina; V. Lavrentjevs; I. Trapina; J. Klovins; D. Andersone; A. Lejnieks; L. Nikitina-Zake
01/24/2013
P2X7; Polymorphism; Tuberculosis

Susceptibility to tuberculosis may be influenced by variations in human genes. The P2X7 receptor is an ATP-gated cation channel expressed in immune cells, and it influences the release of proinflammatory cytokines from monocytes and macrophages. In the present study, we aimed to evaluate the impact of P2X7 gene rs2393799 (-762T/C) and rs1718119 (Thr348Ala) polymorphisms ... more

G. Bahari; M. Hashemi; M. Taheri; M. Naderi; A. Moazeni-Roodi; H.R. Kouhpayeh; E. Eskandari-Nasab
09/25/2012
CD14; Chinese Han; SNPs; Tuberculosis

Although the role of CD14 in mediating signals from Toll-like receptors to recognize Mycobacterium tuberculosis is known, how polymorphisms in this gene affect the susceptibility to develop tuberculosis are still not clear. We examined whether single nucleotide polymorphisms at positions -1145 and -159 in the promoter region of the CD14 gene are associated with tuberculosis in a ... more

M.Y. Zhao; Y. Xue; Z.Q. Zhao; F.J. Li; D.P. Fan; L.L. Wei; X.J. Sun; X. Zhang; X.C. Wang; Y.X. Zhang; J.C. Li
04/27/2012
Polymorphism; PTPN22; Tuberculosis

The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene, which encodes an intracellular lymphoid-specific phosphatase, is considered an important regulator of T-cell activation. We investigated a possible association between the PTPN22 C1858T (R620W) polymorphism and pulmonary tuberculosis in an Iranian population. Single nucleotide polymorphisms of PTPN22 C1858T (rs2476601) ... more

H.R. Kouhpayeh; M. Hashemi; S.A. Hashemi; A. Moazeni-Roodi; M. Naderi; B. Sharifi-Mood; M. Taheri; M. Mohammadi; S. Ghavami
11/11/2014
Anti-tuberculosis drug-induced hepatic injury; Anti-tuberculosis therapy; Gene polymorphism; Metabolic enzyme; Tuberculosis

We examined the relationships between N-transacetylase 2 (NAT2), cytochrome P450 (CYP) 2E1 enzyme, glutathione S-transferase M1, T1 (GSTM1/GSTT1) gene polymorphisms, and anti-tuberculosis drug-induced hepatic injury (ADIH). A one-to-one matched case-control study was carried out using clinical data. NAT2, CYP2E1, GSTM1, and GSTT1 ... more

F.M. Feng; M. Guo; Y. Chen; S.M. Li; P. Zhang; S.F. Sun; G.S. Zhang
05/25/2015
Meta-analysis; Monocyte chemoattractant protein-1; Tuberculosis

Numerous studies have been conducted to investigate the association between 2518A/G polymorphisms in the monocyte chemoattractant protein-1 (MCP-1) gene and the risk of tuberculosis (TB). However, the results have been inconsistent and inconclusive. In this study, we performed a meta-analysis to evaluate the association between the MCP-1 -2518A/G polymorphism and TB. The ... more

G. Tian; X. Li; H. Li; X. Wang; B. Cheng
02/27/2014
DNA repair gene; Glioma; Single-nucleotide polymorphisms

Several single-nucleotide polymorphisms (SNPs) in DNA repair gene have been shown to affect DNA repair and to modify susceptibility to cancer. In this study, to investigate the role of these SNPs in glioma, we examined the potential association of 14 SNPs in DNA repair genes with the glioma risk in a Chinese population. We included 326 glioma cases and 376 cancer-free controls. ... more

K. Gao; S.Q. Mu; Z.X. Wu
04/27/2015
Chinese population; Dopamine receptor D1; Heroin dependence; Single-nucleotide polymorphisms

Previous studies suggested that dopamine receptors may be associated with drug dependence and impulsive behavior. In this study, we examined whether dopamine receptor D1 (DRD1) is associated with heroin dependence and the impulsive behavior in patients with heroin dependence. The participants included 367 patients with heroin dependence and 372 healthy controls from a Chinese Han ... more

J.H. Liu; H.J. Zhong; J. Dang; L. Peng; Y.S. Zhu

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