Research Article

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05/11/2010
Beefmaster; Charolais; IGF1; Polymorphism; SNP IGF1/SnaBI

The IGF1 gene (insulin-like growth factor 1) is a candidate gene for marker-assisted selection strategies. A single nucleotide polymorphism in the promoter region (IGF1/SnaBI) has been reported to be associated with production traits in several cattle breeds. Here, we report its allelic frequencies in Charolais and Beefmaster breeds; we confirm its association with three growth ... more

X.F.De la Rosa Reyna; H.M. Montoya; V.V. Castrellón; A.M.S. Rincón; M.P. Bracamonte; W.A. Vera
04/20/2010
ACE gene; Obstructive sleep apnea syndrome; Polymorphism

Angiotensin-converting enzyme (ACE) is a vital enzyme in the renin-angiotensin-aldosterone system, and there are reports in the literature describing its role in the development of cardiovascular system diseases, with I/D polymorphism of the ACE gene. We examined the relationship between a patient group with obstructive sleep apnea syndrome (OSAS) and a control group in terms of I/D ... more

T. Yakut; M. Karkucak; A. Ursavas; T. Gulten; B. Burgazlioglu; O. Gorukmez; M. Karadag
04/13/2010
Bladder cancer; CCR2-V64I; Chemokines; MCP-1 A-2518G; Polymorphism

Chemokines are potent proinflammatory cytokines that are implicated in numerous inflammatory diseases. Proinflammatory gene polymorphisms lead to variations in the production and concentration of inflammatory proteins. We investigated a possible association between polymorphisms in chemokine and chemokine receptor genes (MCP-1 A-2518G and CCR2-V64I) and bladder cancer risk. Genotypes were ... more

K.F. Narter; B. Agachan; S. Sozen; Z.B. Cincin; T. Isbir
04/06/2010
DNA repair; Endometriosis; Polymorphism; XRCC3 Thr/Thr

Several polymorphisms in the DNA repair gene are thought to have significant effects on cancer risk. We investigated the association of polymorphisms in the DNA repair genes XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys with endometriosis risk. Genotypes were determined by PCR-RFLP assays in 52 patients with endometriosis and 101 age- ... more

R. Attar; C. Cacina; S. Sozen; E. Attar; B. Agachan
03/09/2010
Abnormal Hb; Anemia; Hemoglobinopathies; Polymorphism; thalassemia

We looked for abnormal hemoglobins in blood samples sent for diagnosis of anemia. Identification of the hemoglobins was made using electrophoretic, chromatographic and molecular procedures. The 2020 blood samples were of patients from various regions of Brazil and from some other Latin American countries. Among the abnormal hemoglobins that we found, 3.5% are known to be rare, while 51% ... more

P.J.A. Zamaro; C.R. Bonini-Domingos
04/13/2010
Colorectal cancer; Kashmir; Polymorphism; Restriction digestion; RFLP; TP53

Two TP53 gene polymorphisms at codon 47 (TP53 Pro47Ser) and at codon 72 (TP53 Arg72Pro) have been associated with susceptibility to various cancers. We carried out a case-control study and examined the genotype distribution of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms (SNPs), using a PCR-RFLP approach, to determine if these two SNPs are ... more

A.S. Sameer; Z.A. Shah; N. Syeed; M.Z. Banday; S.M. Bashir; B.A. Bhat; M.A. Siddiqi
01/19/2010
Elderly; HDL cholesterol; Lipoprotein lipase; Polymorphism; Triglycerides

Lipoprotein lipase is essential for triglyceride hydrolysis. The polymorphisms S447X in exon 9 and HindIII in intron 8 have been associated with lower triglyceride levels and lower cardiovascular risk in adult men. We examined the association of these lipoprotein lipase polymorphisms with high-density lipoprotein (HDL) and triglyceride levels in elderly men. Blood samples were ... more

L.M.Q. Araújo; M.S. Cendoroglo; C.O. Gigek; E.S. Chen; deA.C. Smith
12/19/2013
Cerebrovascular disease; Meta-analysis; Methylenetetrahydrofolate reductase; Polymorphism; Stroke

Several independent studies have reported the role of the methylenetetrahydrofolate reductase gene (MTHFR) A1298C polymorphism in strokes, but the results are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed in the present study. In this meta-analysis, a total of 13 studies, including 1974 cases and 2660 controls, were selected ... more

Q.Q. Lv; J. Lu; W. Wu; H. Sun; J.S. Zhang
12/13/2013
Mastitis; PCR-PIRA; PCR-RFLP; Percentage of fat; PGLYRP-2 gene; Polymorphism

Peptidoglycan recognition protein 2 (PGLYRP-2), which belongs to the PGRP family, is the only member that has no direct bactericidal activity but has N-acetylmuramoyl-l-alanine amidase activity. This feature of PGLYRP-2 indicates that it may play an important role in eliminating the pathogen associated molecular pattern (PAMP), such as peptidoglycan (PGN), which can reduce ... more

H.L. Wang; Z.X. Li; L. Chen; J. Yang; L.J. Wang; H. He; F.B. Niu; Y. Liu; J.Z. Guo; X.L. Liu
12/13/2013
Beef cattle; Carcass and meat quality traits; Myf6; MyoD1; PCR-RFLP; Polymorphism

Myogenic determination factor 1 (MyoD1) and myogenic factor 6 (Myf6) genes belong to the myogenic differentiation (MyoD) gene family, which play key roles in growth and muscle development. The study aimed to investigate the effects of variants in cattle MyoD1 and Myf6 on carcass and meat traits. We screened single nucleotide polymorphisms (SNPs ... more

X.H. Du; Q.F. Gan; Z.R. Yuan; X. Gao; L.P. Zhang; H.J. Gao; J.Y. Li; S.Z. Xu

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