Research Article

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Association study; Carcass traits; Cattle; Microsatellite markers

Investigation of molecular marker effects on production traits is essential to define marker assisted selection strategies in beef cattle. We looked for a possible association of molecular markers and backfat thickness (BFT) and rib eye area (REA) in Canchim (5/8 Charolais + 3/8 Zebu) and MA (offspring of Charolais bulls and 1/2 Canchim + 1/2 Zebu cows) animals raised exclusively on ... more

S.L. Meirelles; G.V. Gouveia; G. Gasparin; M.M. Alencar; J.J.S. Gouveia; L.C.A. Regitano
01/12/2010
Association study; CYP27B1; EDN1; Genetic polymorphisms; GSTP1; Sarcoidosis

Sarcoidosis is a chronic inflammatory disease, characterized by granulomatous inflammation, prominently involving the respiratory system. The etiology of this disease has not yet been elucidated and the contribution of genetic is not yet completely understood. We searched for novel candidate genes, utilizing a system biology approach, based on data from published transcriptional, ... more

A. Maver; I. Medica; B. Salobir; M. Tercelj; B. Peterlin
09/03/2013
Association study; Meta-analysis; Type 2 diabetes; UCP2

Uncoupling protein 2 (UCP2) is a mitochondrial transporter protein and can affect the function of β-cells. We investigated a possible association between functional UCP2 -866G/A and Ala55Val polymorphisms and type 2 diabetes in 715 Hubei Han Chinese. No significant association was found, either for the -866G/A polymorphism (allele, P = 0.254; genotype, P = 0.508) or for the ... more

L.J. Qin; J. Wen; Y.L. Qu; Q.Y. Huang
02/27/2013
Association study; IL-2RA; IL-2RB; Rheumatoid arthritis

Polymorphisms in IL-2RA and IL-2RB genes have been reported to confer susceptibility to rheumatoid arthritis (RA) in European populations. We investigated a possilbe association between SNPs in IL-2RA and IL-2RB genes and RA in a Han Chinese population. rs2104286 in IL-2RA and rs743777 in IL-2RB genes were genotyped in a Han Chinese ... more

J. Zhu; F. He; D.D. Zhang; J.Y. Yang; J. Cheng; R. Wu; B. Gong; X.Q. Liu; S. Ma; B. Zhou
08/06/2012
Association study; Body mass index; CYP17; Obesity

The cytochrome P450c17α gene (CYP17) encodes a key biosynthesis enzyme of estrogen, which is critical in regulating adipogenesis and adipocyte development in humans. We therefore hypothesized that CYP17 is a candidate gene for predicting obesity. In order to test this hypothesis, we performed a family-based association test to investigate the relationship between the ... more

H. Yan; Y. Guo; T.L. Yang; L.J. Zhao; H.W. Deng
04/19/2012
Association study; Brazilian population; Chronic myeloid leukemia; Genetic polymorphisms; Hardy-Weinberg equilibrium

Chronic myeloid leukemia is a hematopoietic stem cell disorder that causes uncontrolled proliferation of white blood cells. Although the clinical and biological aspects are well documented, little is known about individual susceptibility to this disease. We conducted a case-control study analyzing the prevalence of the polymorphisms MTHFR C677T, MTHFR A1298C, del{ ... more

G.S. Lordelo; A.L. Miranda-Vilela; A.K. Akimoto; P.C.Z. Alves; C.O. Hiragi; A. Nonino; M.B. Daldegan; M.N. Klautau-Guimarães; C.K. Grisolia
08/07/2014
Association study; Pancreatic cancer; SNPs; TRIB1 gene

Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues that form the pancreas. To investigate whether the tribbles homolog 1 (Drosophila) gene (TRIB1) is associated with pancreatic cancer in the Chinese Han population, we conducted this case-control study and genotyped 3 single nucleotide polymorphisms (rs2980879, rs2980874, and ... more

X.X. Lu; J.J. Hu; Y. Fang; Z.T. Wang; J.J. Xie; Q. Zhan; X.X. Deng; H. Chen; J.B. Jin; C.H. Peng; J. Liu; H.W. Li; B.Y. Shen
05/16/2014
Association study; BRCA2; Cardiovascular disease; HapMap; Saudi Arabian population; Single nucleotide polymorphism

Abnormalities in the breast cancer tumor suppressor genes (BRCA1 and BRCA2) are associated with breast and ovarian cancer. Recently, two single nucleotide polymorphisms (SNPs; rs11571836 and rs1799943) were identified, both located in untranslated regions of chromosome 13, associated with cardiovascular disease (CVD) in a multi-ethnic population. We examined the ... more

M. Alanazi; N.P. Reddy; J.P. Shaik; S.A. Ajaj; A.A.A. Jafari; H. Saeed; Z. Khan; A.P. Khan
04/08/2014
Association study; Inflammatory bowel diseases; Meta-analysis; Polymorphism; Vitamin D receptor

The gene encoding vitamin D receptor (VDR) is recognized as a promising candidate for indicating the development of inflammatory bowel disease (IBD). Four genetic polymorphisms (ApaI, BsmI, FokI, TaqI) in VDR have been widely evaluated to determine their association with IBD, and the results of these evaluations are often inconsistent. ... more

L. Wang; Z.T. Wang; J.J. Hu; R. Fan; J. Zhou; J. Zhong
03/17/2014
Association study; H-FABP; Polymorphism; PSMC1; Qinchuan cattle

Growth and carcass traits are economically important quality characteristics of beef cattle and are complex quantitative traits that are controlled by multiple genes. In this study, 2 candidate genes, H-FABP (encoding the heart fatty acid-binding protein) and PSMC1 (encoding the proteasome 26S subunit of ATPase 1) were investigated in Qinchuan beef cattle of China. PCR- ... more

W. Liang; H.L. Zhang; Y. Liu; B.C. Lu; X. Liu; Q. Li; Y. Cao

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