Research Article

Related GMR Articles

06/01/2015
Genetic polymorphism; Microsatellite marker; Silver fox

The silver fox (Vulpes vulpes), a coat color variant of the red fox, is one of the most important fur-bearing animals. To date, development of microsatellite loci for the silver fox has been limited and mainly based on cross-amplification by using canine SSR primers. In this study, 28 polymorphic microsatellite markers were isolated and identified for silver fox through the ... more

S.Q. Yan; C.Y. Bai; S.M. Qi; Y.M. Li; W.J. Li; J.H. Sun
04/27/2015
Genetic polymorphism; Monocyte chemoattractant protein 1; Pulmonary tuberculosis

Pulmonary tuberculosis (PTB) remains one of the most important infectious diseases worldwide. Several studies have suggested that genetic factors may affect the susceptibility to PTB, but the specific genes involved have not been fully characterized. The gene for monocyte chemoattractant protein 1 (MCP-1) has been linked to an increased risk of tuberculosis in some Mexican and ... more

G.L. Shi; L. Yang; Y. Sun; Y.J. Yin; C.X. Song
04/10/2015
Genetic polymorphism; Glioma; PTGS2

Several previous studies indicated that genetic polymorphisms in inflammatory factor genes were associated with glioma risk. However, the relationship between the prostaglandin-endoperoxide synthase 2 (PTGS2) genetic polymorphism and glioma remains unclear in the Chinese population. We selected 199 histologically confirmed adult glioma patients and 199 cancer-free controls for ... more

R.P. Lin; C.Y. Yao; D.X. Ren
04/10/2015
Genetic polymorphism; PARK16; Parkinson’s disease

Recent genome-wide association studies identified 11 risk loci in different populations of familial and sporadic Parkinson’s disease (PD) patients. Few loci have been verified in different European and Asian populations. We also validated 2 new single-nucleotide polymorphisms, rs947211 and rs823144, in PARK16 to explore their association with susceptibility to PD in the Xinjiang Uygur and Han ... more

H. Xia; Q. Luo; X.X. Li; X.L. Yang
03/30/2015
Colostrum; Fcgrt; Genetic polymorphism; IgG; Sheep

The neonatal Fc receptor (FcRn) plays an important role in regulating IgG homeostasis in the body and passive protection to the offspring. Changes in FcRn expression levels caused by genetic polymorphisms of Fcgrt, which encodes FcRn, may lead to inter-individual differences in colostrum IgG levels in sheep. In this study, we sequenced the FcRn partial heavy chain from 179 sheep ... more

Z.H. Tian; F. Shi; F.G. Zhong; D.P. Bai; X.Y. Zhang
03/30/2015
Genetic polymorphism; Meta-analysis; Overactive bladder risk; β3-adrenoceptor genes

Genetic variations in the human β3-adrenoceptor (β3-AR) gene are known to be involved in insufficient relaxation of the bladder muscle during urine storage. The Trp64Arg polymorphism in the β3-AR gene has been found to be an important regulator of the development of overactive bladder (OAB). However, the association between this polymorphism and OAB remains controversial. Therefore, we ... more

H.C. Qu; W. Zhang; Y.L. Liu; P. Wang
06/22/2010
Association study; Major depressive disorder; Rs6311; Serotonin 2A receptor; Single nucleotide polymorphism; Thai population

Several lines of evidence suggest a molecular role of -1438A/G single nucleotide polymorphism in the 5-HTR2A gene promoter (rs6311) in regulating the expression of this gene, making rs6311 polymorphism a promising candidate for an association study. We looked for a possible association between rs6311 polymorphism and major depressive disorder (MDD) in a northeastern Thai ... more

T. Tencomnao; V. Thongrakard; W. Phuchana; T. Sritharathikhun; S. Suttirat
03/30/2010
Association study; DAT1; Major depressive disorder; rs40184; Single nucleotide polymorphism; Thai population

Several lines of evidence suggest that the dopaminergic system is involved in the pathophysiology of major depressive disorder (MDD). Since the dopamine transporter (DAT1, also known as SLC6A3), mediates the active reuptake of dopamine from the synapses and thereby plays a vital role in the regulation of dopaminergic neurotransmission, we looked for a possible association between the C/T ... more

N. Pattarachotanant; T. Sritharathikhun; S. Suttirat; T. Tencomnao
12/05/2003
Dynamic mutation; Genetic polymorphism; SCA1; SCA2; Spinocerebellar ataxia

Dynamic mutation involves the expansion of a tandem arrayed DNA sequence that is polymorphic in the population. This mechanism is associated with neurological/neuromuscular disorders and the pathology depends on the extension of the repeated tract, with a specific threshold for each disease. We made a PCR-based characterization of allelic polymorphism of SCA1 and SCA2 loci in a sample of 200 ... more

S.F.P. Duarte; R.S. Gestinari; M. Campos-Jr.; M.M.G. Pimentel; M.A.Costa Lima
10/05/2007
Genetic polymorphism; Leptin; Leptin receptor; Obesity; β3-adrenergic receptor

Obesity is due to the combined effects of genes, environment, lifestyle, and the interactions of these factors. The adrenergic receptor β3 (β3-AR), leptin (LEP) and leptin receptor (LEPR) genes have been intensively evaluated in the search of variants that could be related to obesity and its cardiometabolic complications. The results of most of these studies have ... more

S.F.P. Duarte; E.A. Francischetti; V.A. Genelhu; P.H. Cabello; M.M.G. Pimentel

Pages