Research Article

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02/02/2010
Association study; Psoriasis; Psoriasis subtype; Serotonin 2A receptor; Single nucleotide polymorphism; Thai population

Expression of serotonin 2A receptor (5-HTR2A) is known to increase in psoriasis, a chronic inflammatory skin disease. We investigated a possible association between the -1438A/G single nucleotide polymorphism (rs6311) in the promoter region of 5-HTR2A gene and psoriasis in a Thai population. One hundred and twelve psoriatic patients and 151 unrelated healthy controls ... more

C. Ronpirin; T. Tencomnao; J. Wongpiyabovorn
04/07/2009
aldosterone; cortisol; Genetic polymorphism; MDR1; menstrual cycle; P-glycoprotein

ABCB1, also known as MDR1/P-glycoprotein, can transport cortisol and aldosterone. We examined the effects of ABCB1 polymorphisms on serum levels of cortisol and aldosterone among different phases of the normal menstrual cycle in 51 non-pregnant healthy Japanese female volunteers (22 ± 1 years old). The menstrual cycle was divided into three phases: premenstrual phase (14 days preceding the ... more

T. Nakamura; N. Okamura; M. Yagi; H. Omatsu; M. Yamamori; A. Kuwahara; K. Nishiguchi; M. Horinouchi; K. Okumura; T. Sakaeda
02/01/2008
ABO blood group; ABO gene; Brazilian population; DNA polymorphism; Genetic polymorphism; Leukemia

The ABO blood group is the most important blood group system in transfusion medicine and organ transplantation. To date, more than 160 ABO alleles have been identified by molecular investigation. Almost all ABO genotyping studies have been performed in blood donors and families and for investigation of ABO subgroups detected serologically. The aim of the ... more

M.C.Z. Novaretti; A.E. Domingues; R. Manhani; E.M. Pinto; P.E. Dorlhiac-Llacer; D.A.F. Chamone
12/12/2011
Genetic polymorphism; Hypertension; Mongolian; Peroxisome proliferator-activated receptor gamma coactivator-1 alpha

We investigated a possible association of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) Gly482Ser polymorphism with hypertension in Mongolians in Inner Mongolia. A total of 787 subjects were enrolled randomly, including 390 hypertension patients and 397 healthy controls. Triglycerides, cholesterol, and fasting plasma glucose were measured, and body mass ... more

X.L. Su; H.R. Dong; M.R. Yan; H.W. Cui; L. Yang; F.Q. Han
09/16/2011
Bovine C/EBPa gene; Genetic polymorphism; Meat quality traits; PCR-SSCP

CCAAT/enhancer-binding protein alpha (C/EBPa) is an essential transcriptional factor regulating the differentiation of adipocytes. We report a novel single nucleotide polymorphism (C271A) of the C/EBPa gene in six indigenous Chinese cattle breeds using PCR-SSCP and DNA sequencing methods. Allele frequencies were investigated and evaluated by the χ2 test in 817 individuals; all ... more

H. Wang; L.S. Zan; H.B. Wang; F.B. Song
05/24/2011
ESRD; Genetic polymorphism; Interleukin; VNTR

Variable number of tandem repeats (VNTR) polymorphism in the interleukin 4 (IL-4) gene has been associated with end-stage renal disease (ESRD) subjects in many different populations, although with conflicting results. We determined the 70 bp of VNTR polymorphism at intron 3 of the IL-4 gene in Malaysian ESRD subjects. Buccal cells were collected from 160 case and 160 control subjects; ... more

R. Vasudevan; M.N. Norhasniza; I. Patimah
09/14/2010
CYP2C19; CYP2C9; Genetic polymorphism; Mongolian population

We examined the distribution of major allelic variants of CYP2C9 and CYP2C19 in the Mongolian population of China and compared it with that of other populations. The polymorphisms of CYP2C9 (including the CYP2C9*1, CYP2C9*2 and CYP2C9*3 alleles) and CYP2C19 (including the CYP2C19*1, CYP2C19*2 and CYP2C19*3 ... more

Z.F. Yang; H.W. Cui; T. Hasi; S.Q. Jia; M.L. Gong; X.L. Su
07/27/2010
ABO blood system; Brazilian Amazon region; Genetic polymorphism; Malaria; Plasmodium falciparum

We investigated the ABO genotypes and heterogeneity of the O alleles in Plasmodium falciparum-infected and non-infected individuals from the Brazilian Amazon region. Sample collection took place from May 2003 to August 2005, from P. falciparum malaria patients from four endemic regions of the Brazilian Amazon. The control group consisted of donors from four ... more

D.B. Carvalho; L.C. de Mattos; W.C. Souza-Neiras; C.R. Bonini-Domingos; A.B. Cósimo; L.M. Storti-Melo; G.C. Cassiano; A.A.A. Couto; A.J. Cordeiro; A.R.B. Rossit; R.L.D. Machado
05/11/2010
Chronic obstructive pulmonary disease; Genetic polymorphism; Glutathione S-transferase

Chronic obstructive pulmonary disease (COPD) is a multifactorial disease with possible genetic predisposition and involvement of various environmental factors. Several candidate genes have been reported as potentially associated with this lung disease. The glutathione S-transferase P1 gene (GSTP1) was proposed to be involved in susceptibility to develop COPD. It belongs to the ... more

R. Lakhdar; S. Denden; J. Knani; N. Leban; H. Daimi; M. Hassine; G. Lefranc; J. Ben Chibani; H. Khelil
05/14/2013
Genetic polymorphism; Glioma; Glutathione S-transferases; Perillyl alcohol

GSTM1 (glutathione S-transferase mu 1) and GSTT1 (glutathione S-transferase theta 1) are critical enzymes for detoxification of endogenous and environmental carcinogens. Constitutive GST gene polymorphisms may be associated with increased risk for cancer development. We made an explorative study of a Brazilian population with malignant glioma to determine whether ... more

M.M. Silva; C.O. Da Fonseca; R. Moura-Neto; J.F. Carvalho; T. Quirico-Santos; M.G. Carvalho

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