Research Article

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CD14; Chinese Han; SNPs; Tuberculosis

Although the role of CD14 in mediating signals from Toll-like receptors to recognize Mycobacterium tuberculosis is known, how polymorphisms in this gene affect the susceptibility to develop tuberculosis are still not clear. We examined whether single nucleotide polymorphisms at positions -1145 and -159 in the promoter region of the CD14 gene are associated with tuberculosis in a ... more

M.Y. Zhao; Y. Xue; Z.Q. Zhao; F.J. Li; D.P. Fan; L.L. Wei; X.J. Sun; X. Zhang; X.C. Wang; Y.X. Zhang; J.C. Li
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Polymorphism; PTPN22; Tuberculosis

The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene, which encodes an intracellular lymphoid-specific phosphatase, is considered an important regulator of T-cell activation. We investigated a possible association between the PTPN22 C1858T (R620W) polymorphism and pulmonary tuberculosis in an Iranian population. Single nucleotide polymorphisms of PTPN22 C1858T (rs2476601) ... more

H.R. Kouhpayeh; M. Hashemi; S.A. Hashemi; A. Moazeni-Roodi; M. Naderi; B. Sharifi-Mood; M. Taheri; M. Mohammadi; S. Ghavami
11/11/2014
Anti-tuberculosis drug-induced hepatic injury; Anti-tuberculosis therapy; Gene polymorphism; Metabolic enzyme; Tuberculosis

We examined the relationships between N-transacetylase 2 (NAT2), cytochrome P450 (CYP) 2E1 enzyme, glutathione S-transferase M1, T1 (GSTM1/GSTT1) gene polymorphisms, and anti-tuberculosis drug-induced hepatic injury (ADIH). A one-to-one matched case-control study was carried out using clinical data. NAT2, CYP2E1, GSTM1, and GSTT1 ... more

F.M. Feng; M. Guo; Y. Chen; S.M. Li; P. Zhang; S.F. Sun; G.S. Zhang
05/25/2015
Meta-analysis; Monocyte chemoattractant protein-1; Tuberculosis

Numerous studies have been conducted to investigate the association between 2518A/G polymorphisms in the monocyte chemoattractant protein-1 (MCP-1) gene and the risk of tuberculosis (TB). However, the results have been inconsistent and inconclusive. In this study, we performed a meta-analysis to evaluate the association between the MCP-1 -2518A/G polymorphism and TB. The ... more

G. Tian; X. Li; H. Li; X. Wang; B. Cheng
02/27/2014
DNA repair gene; Glioma; Single-nucleotide polymorphisms

Several single-nucleotide polymorphisms (SNPs) in DNA repair gene have been shown to affect DNA repair and to modify susceptibility to cancer. In this study, to investigate the role of these SNPs in glioma, we examined the potential association of 14 SNPs in DNA repair genes with the glioma risk in a Chinese population. We included 326 glioma cases and 376 cancer-free controls. ... more

K. Gao; S.Q. Mu; Z.X. Wu
04/27/2015
Chinese population; Dopamine receptor D1; Heroin dependence; Single-nucleotide polymorphisms

Previous studies suggested that dopamine receptors may be associated with drug dependence and impulsive behavior. In this study, we examined whether dopamine receptor D1 (DRD1) is associated with heroin dependence and the impulsive behavior in patients with heroin dependence. The participants included 367 patients with heroin dependence and 372 healthy controls from a Chinese Han ... more

J.H. Liu; H.J. Zhong; J. Dang; L. Peng; Y.S. Zhu
05/04/2015
Gene mutations; Hepatitis C virus; Hepatocellular carcinoma; Single-nucleotide polymorphisms; TGF-β1 -509 CC genotype; TGF-β1 -509 TT genotype

Transforming growth factor-beta 1 (TGF-β1), a member of the transforming growth factor beta family, functions as a multi-functional cytokine and plays a key role in cellular growth, proliferation, and differentiation. The 509 C/T polymorphism in the TGF-β1 gene has been implicated in the outcome of hepatitis C virus (HCV) infection; however, little is known ... more

J. Ma; Y.C. Liu; Y. Fang; Y. Cao; Z.L. Liu

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