Research Article

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RT-qPCR was used to analyze the vitamin D receptor (VDR) gene TaqI polymorphism in 100 Turkish patients with type 2 diabetes mellitus (T2DM) and hypertension compared with 100 healthy subjects, to determine whether VDR could be considered as one of the susceptibility genes for T2DM and hypertension. Genotyping was done with PCR, followed by melting curve analysis with specific fluorescent ... more

H.C. Vural; E. Maltas
01/10/2014
Cancer; Disparities; IL-6; Polymorphism; Prostate

Interleukin-6 (IL-6), a pro-inflammatory cytokine, is involved in prostate cancer progression, including androgen independence. Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. Since circulating cytokine levels vary considerably inter-individually, such variation could be linked to genetic factors, including genetic polymorphism ... more

S. Mandal; F. Abebe; J. Chaudhary
03/30/2015
Cardiovascular events; Hemodialysis; IL-6; Polymorphism

We aimed to investigate the role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis. Blood samples were collected from 216 patients receiving hemodialysis treatment. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype IL-6 -634C/G, -174G/C and -572C/G. By ... more

Y. Song; H.D. Gu; Y. He; J.W. Wang
07/13/2010
Coronary artery disease; Inflammation; Polymorphism; PPAR-δ

Peroxisome proliferator-activated receptor delta (PPAR-δ) is a transcription factor implicated in metabolism and inflammation. The +294T/C polymorphism in the PPAR-δ gene is associated with risk of coronary artery disease (CAD) in dyslipidemic women and hypercholesterolemic men. Whether this polymorphism influences the risk of CAD in the absence of dyslipidemia was not known, so we ... more

I. Jguirim-Souissi; A. Jelassi; Y. Hrira; M. Najah; A. Slimani; F. Addad; M. Hassine; K.B. Hamda; F. Maatouk; M. Rouis; M.N. Slimane
09/23/2013
Coronary artery disease; Meta-analysis; Polymorphism

The G403A polymorphism in the RANTES (regulated on activation normal T cell expressed and secreted) gene has a key role in the expression of RANTES, which has been detected in a range of cells in atherosclerotic plaque. However, the association of this polymorphism with the risk of coronary artery disease (CAD) remains controversial. A meta-analysis was performed to assess the association ... more

K. Cui; X.Y. Ge; H.L. Ma
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Coronary artery disease; Gene mutation; MEF2A; Polymorphism

We investigated mutations and polymorphisms of the coronary artery disease (CAD)-related myocyte enhancer factor 2A (MEF2A) gene in a Chinese population. Polymerase chain reaction-single-strand conformation polymorphism and DNA sequencing were used to detect exon 11 of the MEF2A gene in 210 Hubei patients with CAD and 190 healthy controls. The following mutations were ... more

J. Li; H.X. Chen; J.G. Yang; W. Li; R. Du; L. Tian
04/08/2014
Coronary artery disease; Genotyping; Polymorphism; Predisposing genes; Single nucleotide

This study investigated 5 single nucleotide polymorphism (SNP) haplotypes in susceptibility genes for coronary artery disease (CAD) and the putative involvement of these SNPs in CAD in the Chi­nese Han population. From March 2008 to June 2009, we selected 119 CAD patients and 115 subjects not related to the CAD of Chinese Han or­igin as controls. The SNP genotypes were performed by ... more

Y.H. Liu; Y.W. Zhou; J.A. Yang; Z.G. Tu; S.Y. Ji; Z.Y. Huang; Z.J. Zhou
02/20/2014
Coronary artery disease; Endothelial lipase; Gene; Polymorphism

A growing body of evidence suggests that the 584C/T polymorphism in the endothelial lipase (EL) gene contributes to the process of coronary artery disease (CAD). The present study aimed to reveal the potential relationship between the EL 584C/T gene polymorphism and early-onset CAD, CAD severity, and lipid levels in a Chinese Han population. Participants comprised 135 early-onset CAD ... more

G.J. Cai; G.P. He; Z.Y. Huang; C.P. Qi
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Coronary artery disease; Interleukin-6; Polymorphism

We conducted a case-control study to investigate the association between IL-6 -174 G>C and -572 C>G polymorphisms and the risk of coronary artery disease (CAD). We genotyped IL-6 ˗174 G>C and -572 C>G in 402 patients with CAD and 402 control individuals. IL-6 -174 G>C (rs1800795) and -572 C>G (rs1800796) alleles were detected by polymerase chain ... more

K. Wang; P.S. Dong; H.F. Zhang; Z.J. Li; X.M. Yang; H. Liu
03/20/2015
Angiotensin-converting enzyme; Coronary artery disease; Polymorphism

We investigated whether the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and serum ACE levels are associated with traditional risk factors of coronary artery disease (CAD). We enrolled 250 individuals without CAD and 750 individuals suffering from CAD who were angiographically diagnosed. Biochemical risk factors, the ACE (I/D) gene ... more

S. Sahin; K. Ceyhan; I. Benli; H. Ozyurt; E. Naseri; M.M. Tumuklu; L. Aydogan; A.O. Elalmis; A.F. Ozugurlu; O. Onalan

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