Research Article

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02/20/2014
Antioxidant; Inflammation; Mutation; Oxidative stress; Polymorphism; Small bowel

Celiac disease (CD) is a multifactorial, inflammatory small bowel disorder characterized by nutrient malabsorption resulting from mucosal damage, the latter induced by cereal products like barley, oat, and wheat. Oxidative stress has previously been reported to play an important role in the pathogenesis of CD. In the present study, we aimed to evaluate the frequency of polymorphisms that ... more

M. Katar; A.F. Ozugurlu; H. Ozyurt; I. Benli
06/30/2005
Antioxidant; Expressed sequence tags; Free radicals; Oxidative stress; Paracoccidioides brasiliensis; Transcription factors

Survival of pathogenic fungi inside human hosts depends on evasion from the host immune system and adaptation to the host environment. Among different insults that Paracoccidioides brasiliensis has to handle are reactive oxygen and nitrogen species produced by the human host cells, and by its own metabolism. Knowing how the parasite deals with reactive species is important to ... more

É.G. Campos; Ada Silva Dantas; Mde Macedo Brigido; Mde Macedo Brigido; M.Sueli S. Felipe; R.Santos Amo Jesuino
12/19/2011
hOGG1; Oxidative stress; Polymorphisms; XPD

Knee replacement surgery is an ischemia/reperfusion model, as it uses tourniquet applied to the knee area to stop the blood flow during the operation. Fifty patients that were undergoing elective arthroscopic knee surgery were included in our study. Human 8-oxoguanine glycosylase 1 (hOGG1) is an enzyme to repair specific DNA lesions and a good marker of hydroxyl radical damage to DNA. XPD ... more

O. İsbir; U. Gormus; H.A. Ergen; B. Cakmakoglu; Ö.T. Kahraman; N. Baykan
07/25/2014
Glucose metabolism; Glucose transport; hydrogen peroxide; Oxidative stress; Schizosaccharomyces pombe; Thiamine

The relationship between glucose repression and the oxidative stress response was investigated in Schizosaccharomyces pombe wild type cells (972h-) and glucose repression resistant mutant type cells (ird11). We aimed to reveal the mechanism of simultaneous resistance to glucose repression and oxidative stress in ird11 mutants. ... more

B. Palabiyik; J. Ghods; O. Ucar
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Familial Mediterranean fever; Gene polymorphism; Glutathione peroxidase; Inflammation; Oxidative stress; Paraoxonase

Familial Mediterranean fever (FMF) is an autosomal recessive disorder and is the most frequent of the periodic febrile inflammatory syndromes. The pathogenesis of the disease is not completely understood, even though the FMF gene has been identified. Oxidative stress and inflammation may play a role in the pathogenesis of FMF. We investigated gene polymorphisms of the antioxidative ... more

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05/11/2015
Ascorbate peroxidase; H2O2; Jatropha curcas; Oxidative stress; Salt stress

Ascorbate peroxidase (APX) plays a central role in the ascorbate-glutathione cycle and is a key enzyme in cellular H2O2 me­tabolism. It includes a family of isoenzymes with different character­istics, which are identified in many higher plants. In the present study, we isolated the APX gene from Jatropha curcas L, which is similar with other ... more

Y. Chen; J. Cai; F. .X.Yang; B. Zhou; L.R. Zhou
03/20/2015
Corynebacterium glutamicum; Oxidative stress; Peptide methionine sulfoxide reductase; Superoxide dismutase

Promoters of genes encoding superoxide dismutase (sodA) and peptide methionine sulfoxide reductase (msrA) from Cory­nebacterium glutamicum were cloned and sequenced. Promoter region analysis of sodA-msrA was unable to identify putative sites of fixed eventual regulators except for possible sites of fixed OxyR and integra­tion host factor. A study of the ... more

H.M.El Shafey; S. Ghanem
09/18/2002
Brazil; Glutathione S-transferase; Polymorphism

The glutathione S-transferase (GST) family of enzymes has a vital role in phase II of biotransformation of environmental carcinogens, pollutants, drugs and other xenobiotics. GSTs are polymorphic, with the type and frequency of polymorphism being ethnic dependent. Polymorphisms in GST genes have been shown to be associated with susceptibility to disease and disease outcome. We ... more

A. Rossini; D.C.M. Rapozo; L.M.F. Amorim; J.M.B. Macedo; R. Medina; J.F.N. Neto; C.V.M. Gallo; L.F.R. Pinto
03/28/2007
Dog breeds; Growth; Polymorphism; SNP; SOCS2

Suppressor of cytokine signaling 2 (SOCS2) is a negative regulator of growth hormone signaling. The deletion of SOCS2 in mice results in a 30-50% increase in post-natal growth. In an effort to identify polymorphisms in the SOCS2 gene that may be associated with body size in dogs, we characterized the canine SOCS2 gene and analyzed its genetic diversity among small and large dog breeds ... more

G. Rincón; A.E. Young; D.L. Bannasch; J.F. Medrano

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