Research Article

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12/30/2004
Bioinformatics; Computing; Modeling; Physics; Post-genomics

I give here a very personal perspective of Bioinformatics and its future, starting by discussing the origin of the term (and area) of bioinformatics and proceeding by trying to foresee the development of related issues, including pattern recognition/data mining, the need to reintegrate biology, the potential of complex networks as a powerful and flexible framework for bioinformatics ... more

Lda Fontour Costa
12/12/2011
Genetic polymorphism; Hypertension; Mongolian; Peroxisome proliferator-activated receptor gamma coactivator-1 alpha

We investigated a possible association of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) Gly482Ser polymorphism with hypertension in Mongolians in Inner Mongolia. A total of 787 subjects were enrolled randomly, including 390 hypertension patients and 397 healthy controls. Triglycerides, cholesterol, and fasting plasma glucose were measured, and body mass ... more

X.L. Su; H.R. Dong; M.R. Yan; H.W. Cui; L. Yang; F.Q. Han
12/04/2013
Chinese Han population; Hypertension; Single nucleotide polymorphism

Human hypertension is a complex, multifactorial disease. Multiple variants associated with hypertension have been identified in the large numbers of genome-wide association studies, meta-analysis, and case-control studies. The present study investigated the association between the single nucleotide polymorphisms (SNPs) of five candidate genes and the susceptibility and prognosis of ... more

G.L. Hong; X.Z. Chen; Y. Liu; Y.H. Liu; X. Fu; S.B. Lin; Q. Zhu
03/14/2012
Diabetes mellitus; Hypertension; Polymorphism; RT-qPCR; VDR gene

RT-qPCR was used to analyze the vitamin D receptor (VDR) gene TaqI polymorphism in 100 Turkish patients with type 2 diabetes mellitus (T2DM) and hypertension compared with 100 healthy subjects, to determine whether VDR could be considered as one of the susceptibility genes for T2DM and hypertension. Genotyping was done with PCR, followed by melting curve analysis with specific fluorescent ... more

H.C. Vural; E. Maltas
07/07/2014
Cardiac remodeling; Diastolic function; High-sensitivity troponin T; Hypertension

It has been well established that high-sensitivity cardiac troponin T (hs-TnT) is a specific and highly sensitive marker in acute coronary syndromes. On the other hand, studies on serum concentrations of hs-TnT in patients with hypertension in the absence of significant coronary stenosis are limited. Therefore, we hypothesized that hs-TnT levels are related to left ventricular (LV) ... more

D.M. Miao; L.P. Zhang; H.P. Yu; J.Y. Zhang; W.K. Xiao; P. Ye
04/16/2014
Gln27Glu polymorphism; Hypertension; PCR-RFLP; β2 adrenoceptor

The sympathetic nervous system plays a major role in blood pressure regulation. Beta 2 (β2) adrenoceptor gene polymorphisms have been associated with hypertension in different populations with conflicting results. We examined the association of three common polymorphisms, Arg16Gly, Gln27Glu, and Thr164Ile, of the β2 adrenoceptor gene in Malaysian hypertensive subjects. A total of 160 ... more

M. Komara; R. Vasudevan; P. Ismail; S.A. Bakar; S.R. Pishva; F. Heidari
02/21/2014
Hypertension; Ischemia; Lysophosphatidic acid; Novel phospholipid (AP); Pulse pressure

The aim of this study was to analyze the association between pulse pressure and a novel type of phospholipid with solubility similar to that of lysophosphatidic acid (LPA), designated as AP, which was reported to be elevated during ischemia. In this cross-sectional study, 416 hypertensive patients and 252 controls aged between 35 and 70 years were enrolled consecutively. Fasting blood ... more

C.S. Yao; Q.Z. Wu; H.X. Xu; F. Liu; L.G. Chang; L.C. Song; L.S. Gao; X.L. Meng
01/21/2014
CYP4A11; Han Chinese; Hypertension; Mongolians

Human cytochrome P450 4A11 (CYP4A11) plays a role in the regulation of blood pressure through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE). We therefore investigated the association between a CYP4A11 polymorphism (rs9333025) with hypertension in the Mongolian and Han ethnic groups. We studied 514 Mongolians in a pastoral area, including 201 ... more

J.Q. Liang; M.R. Yan; L. Yang; Q. Suyila; H.W. Cui; X.L. Su
05/11/2015
Carotid artery intima-media thickness; Hypertension; Serum sulfatide

Hypertension is a major traditional risk factor for atherosclerosis, and carotid artery intima-media thickness (IMT) is considered to be an important marker of atherosclerosis. Sulfatides have been shown to play a role in atherogenesis and vascular inflammation, resulting in atherosclerosis. This study aimed to assess the association between serum sulfatide and carotid artery IMT among ... more

G. Li; R. Hu; J. Gu; H.Z. Wu
09/21/2015
c-Jun N-terminal kinases; CAAT/enhanced I-binding protein; Endoplasmic reticulum stress; Hypertension; Ischemia/reperfusion

Acute brain ischemia can induce the activation of c-Jun N-terminal kinases (JNKs). Hypertension is a critical etiology for brain ischemia. We identified the effects of hypertension on the activation of JNK as well as its impact on SP600125, a JNK inhibitor, during endoplasmic reticulum stress (ERS) in the hippocampus using a rat model. Transient whole-brain ischemia was induced by 4- ... more

Y.N. Zhao; J.M. Li; C.X. Chen; P. Zhang; S.X. Li

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