Research Article

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05/04/2015
Bioinformatics; Biomarkers; Cancer; Immunohistochemistry

Identification of cancer-associated and tissue-specific proteins is important for research on carcinogenesis mechanisms and biomarker discovery. Here we performed a new strategy to identify candidate cancer proteins by mining immunohistochemistry protein profiles. Proteins with quantitative values from 14 normal tissues and their corresponding cancer tissues were compared and analyzed ... more

X.X. Liu; F.J. Liu
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Cerebral aneurysm; Immunohistochemistry; NOS

We sought to investigate the relationship between abnormal expression of nitric oxide synthase (NOS) and pathogenesis of cerebral aneurysm. Brain tissues were collected from 36 patients with cerebral aneurysm confirmed by computer tomography with angiography or neurosurgical therapy. The control group consisted of 25 patients of similar age who had no vascular diseases, as confirmed by ... more

W.S. Liu; H.J. Geng; C.D. Wang; A.J. Li; P.C. Cao; D.K. Wang; G. Li
04/28/2015
Breast neoplasm; EGFR; Immunohistochemistry; Molecular subtypes; p53

This study aimed to explore new opportunities for developing targeted therapy for triple-negative breast cancer (TNBC) by analyzing the significance and association between p53 and epidermal growth factor receptor (EGFR) expression in different molecular subtypes of breast cancer. The clinical and pathological data of 264 patients with breast cancer receiving surgery in our hospital from ... more

X.Z. Wang; Q. Liu; J.J. Sun; W.S. Zuo; D.W. Hu; S.G. Ma; D.B. Mu; Z.Y. Yu
04/13/2015
Breast cancer; Immunohistochemistry; Special AT-rich sequence binding protein 1

Special AT-rich sequence binding protein 1 (SATB1) is a recently discovered gene regulator that can promote the growth and metastasis of breast cancer. However, its expression in different stages of breast cancer development have not been examined. We explored the role of SATB1 in the development of breast cancer by detecting SATB1 expression levels in different stages of breast cancer. ... more

S. Zhang; X. Gao; Y. Ma; J. Jiang; Z. Dai; X. Yin; W. Min; W. Hui; B. Wang
09/09/2015
Global cerebral ischemia-reperfusion; Immunohistochemistry; Intermittent hypobaric hypoxia

This study was aimed at understanding the effect of intermittent hypobaric hypoxia preconditioning (IHHP) on neuroglobin (NGB) and Bcl-2 expression in the hippocampal CA1 region of rats following global cerebral ischemia-reperfusion. Wistar rats were randomly divided into sham, IHHP control, global cerebral ischemia-reperfusion (IR group), and IHHP+IR groups. The four-vessel occlusion rat ... more

Q. Wu; K.X. Yu; Q.S. Ma; Y.N. Liu
10/24/2013
BRAF gene; Denaturing high-performance liquid chromatography; Multiplex allele-specific PCR; Prognosis; V600E mutation

Mutations in the V-raf murine sarcoma viral oncogene homolog B1 gene (BRAF) play an important role in the pathogenesis of papillary thyroid cancer (PTC). In this study, a BRAF V600E mutation was detected in formalin-fixed and paraffin-embedded PTC samples using multiplex allele-specific polymerase chain reaction and denaturing high-performance liquid chromatography. The ... more

R.X. Gong; Y.P. Gong; J. Yang; T. Wei; J. Li-Ling; J.Q. Zhu
12/12/2014
Gastric cancer; Meta-analysis; Prognosis; S100A4

The prognostic role of S100A4 in gastric cancer is still under debate. The present meta-analysis aimed to evaluate the relationship between S10A4 levels and the prognosis of gastric cancer. We performed a meta-analysis of published studies assessing the relationship between S100A4 and gastric cancer prognosis. We used the Revman 5.0 software to perform literature retrieval, article ... more

Y. Wang; L.B. Zhou; X.H. Li
12/04/2014
Acute lymphoblastic leukemia; Adolescent; Child; Myeloid anomalous expression; Platelet count; Prognosis

The aim of this study was to evaluate myeloid expression in acute lymphoblastic leukemia (ALL) in children and adolescents who had been referred to the Oncology Department in a hospital in the State of Maranhão based on demographic, laboratory, and clinical data. Myeloid expression was evaluated in 65 patients under 18 years of age who were diagnosed with morphological, cytochemical, and ... more

T.C. Lopes; K.N.S. Andrade; N.L. Camelo; V.P. Rodrigues; R.A.G. Oliveira
11/07/2014
Advanced oxidation protein products; Biomarker; Case-control study; Cutaneous lupus erythematosus; Lupus nephritis; Prognosis

Oxidative stress is involved in the pathogenesis of lupus nephritis (LN). The current study investigated the significance of advanced oxidation protein products (AOPPs) as a biomarker of LN in patients with cutaneous lupus erythematosus. Ninety-two patients who initially presented with systemic lupus erythematosus were divided into the LN- and LN+ groups. Serum AOPP levels were determined ... more

Z. Xie; M. Zhang; B. Zhao; Q. Wang; J. Li; Y.Y. Liu; Y.H. Chen
09/29/2014
Ezrin; Laryngeal squamous cell carcinoma; Metastasis; Moesin; Prognosis

We examined the expression of ezrin and moesin in laryngeal squamous cell carcinoma (LSCC) and their correlation with patient clinicopathological characteristics and overall survival. Immunohistochemical staining and reverse transcription-polymerase chain reaction (RT-PCR) for ezrin and moesin were applied to 60 carcinoma tissues, adjacent normal tissues, and 33 metastatic lymph nodes. ... more

X. Wang; M. Liu; C.Y. Zhao

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