Research Article

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03/12/2014
5-HT; Haplotype; Paranoid schizophrenia; Serotonin; SNP; TPH2

In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nucleotide polymorphisms (SNPs) in the regulatory regions of TPH2 ... more

X.M. Xu; M. Ding; H. Pang; B.J. Wang
01/14/2014
Association analysis; Pig; Reproductive trait; RFRP gene; SNP

RFamide-related peptide (RFRP) gene is a crucial gene of the hypothalamo-pituitary-gonadal axis and plays an important role in reproduction regulation. This study aimed to clone and characterize the pig RFRP gene. We obtained a 645-bp cDNA of pig RFRP gene comprising a 546-bp open reading frame, which encoded a peptide of 188 amino acids. The pig RFRP coding ... more

M.X. Fang; Y.S. Huang; J. Ye; W. Zhang; Y. Li; Q.H. Nie
03/12/2014
AS-PCR (allele-specific PCR); IGFBP-5 gene; Pigs; SNP

The genetic resources and the mechanism of miniaturization in the Tibet Mini-pig have not been comprehensively studied. Polymorphisms in genes related to the insulin-like growth factor (IGF) axis have been investigated for years, but few on the polymorphism of IGF-binding protein-5 (IGFBP-5) in the Tibetan pig. In this study, allele-specific polymerase chain reaction (AS-PCR) was used to ... more

A.D. Chen; L.L. Hao; X.B. Fang; K. Lu; S.C. Liu; Y.L. Zhang
01/10/2014
Breast cancer; Han nationality: PCR-SSCP; SNP; Trinucleotide-repeat-containing 9

A single nucleotide polymorphism (SNP) in the TNRC9 gene was identified as a breast cancer susceptibility genetic variant in recent genome-wide association studies of women of European ancestry. We investigated whether TNRC9 polymorphisms are associated with risk of breast cancer in Chinese women of the Han nationality. We genotyped the SNPs rs3803662, rs1362548, rs1123428 in 870 women, ... more

F. Chen; J. Zhou; Y. Xue; S. Yang; M. Xiong; Y. Li; Q. Liu
06/18/2015
Gene; Intracranial aneurysm; Risk factor; SNP

Few studies have examined the genes related to risk fac­tors that may contribute to intracranial aneurysms (IAs). This study in Chinese patients aimed to explore the relationship between IA and 28 gene loci, proven to be associated with risk factors for IA. We recruited 119 patients with aneurysms and 257 controls. Single factor and logistic regression models were used to analyze the ... more

L.T. Zhang; F.J. Wei; Y. Zhao; Z. Zhang; W.T. Dong; Z.N. Jin; F. Gao; N.N. Gao; X.W. Cai; N.X. Li; W. Wei; F.S. Xiao; S.Y. Yue; J.N. Zhang; S.Y. Yang; W.D. Li; X.Y. Yang
03/31/2015
Ancestry informative markers; Association studies; Brazilian genetic admixture; Ethnicity; Population structure; SNP

Genetic association studies determine how genes influence traits. However, non-detected population substructure may bias the analysis, resulting in spurious results. One method to detect substructure is to genotype ancestry informative markers (AIMs) besides the candidate variants, quantifying how much ancestral populations contribute to the samples’ genetic background. The present study ... more

A.V.C. Coelho; R.R. Moura; C.A.J. Cavalcanti; R.L. Guimarães; P. Sandrin-Garcia; S. Crovella; L.A.C. Brandão

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