Research Article

Related GMR Articles

03/30/2015
Fatty acid synthase gene; Meat quality traits; Polymorphism; Yak

Fatty acid synthase (FASN) is a key enzyme in fatty acid anabolism that plays an important role in the fat deposit of eukaryotic cells. Therefore, in this study, we detected 2 novel single-nucleotide polymorphisms (SNPs) in the FASN gene in 313 adult individuals of Datong yak using polymerase chain reaction-single strand conformation polymorphism and DNA sequencing techniques. SNP ... more

M. Chu; X.Y. Wu; X. Guo; J. Pei; F. Jiao; H.T. Fang; C.N. Liang; X.Z. Ding; P.J. Bao; P. Yan
12/05/2003
Dynamic mutation; Genetic polymorphism; SCA1; SCA2; Spinocerebellar ataxia

Dynamic mutation involves the expansion of a tandem arrayed DNA sequence that is polymorphic in the population. This mechanism is associated with neurological/neuromuscular disorders and the pathology depends on the extension of the repeated tract, with a specific threshold for each disease. We made a PCR-based characterization of allelic polymorphism of SCA1 and SCA2 loci in a sample of 200 ... more

S.F.P. Duarte; R.S. Gestinari; M. Campos-Jr.; M.M.G. Pimentel; M.A.Costa Lima
10/05/2007
Genetic polymorphism; Leptin; Leptin receptor; Obesity; β3-adrenergic receptor

Obesity is due to the combined effects of genes, environment, lifestyle, and the interactions of these factors. The adrenergic receptor β3 (β3-AR), leptin (LEP) and leptin receptor (LEPR) genes have been intensively evaluated in the search of variants that could be related to obesity and its cardiometabolic complications. The results of most of these studies have ... more

S.F.P. Duarte; E.A. Francischetti; V.A. Genelhu; P.H. Cabello; M.M.G. Pimentel
01/22/2008
Down syndrome; Genetic polymorphism; Nondisjunction; Trisomy 21

The aim of the present study was to investigate the effect of polymorphisms C677T and A1298C in the methylenetetrahydrofolate reductase (MTHFR) gene, A2756G in methionine synthase reductase (MTR) gene and A80G in reduced folate carrier 1 (RFC1) gene, and plasma homocysteine (Hcy), on the maternal risk for Down syndrome (DS). Seventy-two DS mothers and 194 mothers who ... more

J.M. Biselli; E.M. Goloni-Bertollo; B.L. Zampieri; R. Haddad; M.N. Eberlin; E.C. Pavarino-Bertelli
05/17/2011
Acid phosphatase locus 1; Favism; Genetic polymorphism; Glucose-6-phosphate dehydrogenase deficiency; LMW protein tyrosine phosphatases

An association between favism (a hemolytic reaction to consumption of fava beans), glucose-6-phosphate dehydrogenase deficiency (G6PD-) and acid phosphatase locus 1 (ACP1) phenotypes has been reported; the frequency of carriers of the pa and pc ACP1 alleles was found to be significantly higher in G6PD- individuals showing favism than in the general ... more

V. Polzonetti; V. Passini; N. Lucarini
11/17/2011
Bos taurus; Carcass traits; Chemerin gene; PCR-SSCP; SNP

Qinchuan is a red or yellow draft and beef breed in China. In order to identify a predictor of carcass traits on the basis of associations between carcass traits and gene polymorphism, variation in the bovine chemerin gene was investigated using PCR-single-strand conformational polymorphism and DNA sequencing. An SNP of A868G located in exon 2 of the Bos taurus chemerin gene was ... more

W.Q. Tian; H.C. Wang; F.B. Song; L.S. Zan; H. Wang; H.B. Wang; Y.P. Xin; J.A. Ujan
09/09/2011
ACOX1 gene; Cattle; PCR-SSCP; SNP; Ultrasound traits

Acyl-coenzyme A oxidase 1 (ACOX1) is the first enzyme in peroxisomal fatty acid β-oxidation; it is rate-limiting and plays a key role in fatty acid metabolism and fat deposition. ACOX1 is an important candidate gene for meat quality selection through marker-assisted selection. Genomic structural analysis showed that bovine ACOX1 shares 86% identity with human ACOX1. Using PCR-SSCP ... more

Y. Jiao; L.S. Zan; Y.F. Liu; H.B. Wang
08/16/2011
IGF-1; PCR-SSCP; SNP

The IGF-1 gene has been implicated as a candidate gene for the regulation of pig growth traits. We analyzed exons 3 and 4 of IGF-1 gene polymorphisms of the Banna mini-pig (28), the Tibetan mini-pig (30), the Junmu pig (55), and L. Yorkshire species (50) using PCR-SSCP. Three genotypes in exon 3 and 6 genotypes in exon 4 were observed, among which, one single nucleotide polymorphism, ... more

L.L. Hao; H. Yu; Y. Zhang; S.C. Sun; S.C. Liu; Y.Z. Zeng; Y.X. Ai; H.Z. Jiang
04/19/2011
Cattle; Growth traits; PCR-SSCP; SNPs; SST gene

Somatostatins play a crucial role in the regulation of growth and development in vertebrates, especially muscle growth. We assessed the association of somatostatin gene polymorphisms with growth traits by PCR-SSCP (polymerase chain reaction-single strand conformation polymorphism) and DNA sequencing methods in 694 individuals from six Chinese cattle breeds. A novel single nucleotide ... more

L. Gao; L.S. Zan; H.B. Wang; R.J. Hao; X. Zhong
11/09/2010
Body measurement traits; Goat; LF gene; Milk composition; PCR-SSCP; SNP

Milk composition and body measurement traits, influenced by genes and environmental factors, play important roles in value assessments of efficiency and productivity in dairy goats. Lactoferrin (LF), involved in the efficient expression of protein in milk, is also an anabolic factor in skeletal tissue and a potent osteoblast survival factor. Therefore, it is an important candidate gene ... more

B.L. Guo; Y. Jiao; C. He; L.X. Wei; Z.H. Chang; X.P. Yue; X.Y. Lan; H. Chen; C.Z. Lei

Pages