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“CDKAL1 and type 2 diabetes: a global meta-analysis”, vol. 9, pp. 1109-1120, 2010.
, Anonymous (2008). Diagnosis and classification of diabetes mellitus. Diabetes Care 31: (S55-S60).
http://dx.doi.org/10.2337/dc08-S055
PMid:18165338
Boutayeb A and Boutayeb S (2005). The burden of non communicable diseases in developing countries. Int. J. Equity. Health 4: 2.
http://dx.doi.org/10.1186/1475-9276-4-2
PMid:15651987 PMCid:546417
Cauchi S, Meyre D, Durand E, Proenca C, et al. (2008a). Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value. PLoS. One 3: e2031.
http://dx.doi.org/10.1371/journal.pone.0002031
PMid:18461161 PMCid:2346547
Cauchi S, Proenca C, Choquet H, Gaget S, et al. (2008b). Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. J. Mol. Med. 86: 341-348.
http://dx.doi.org/10.1007/s00109-007-0295-x
PMid:18210030
Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, et al. (2006). Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat. Genet. 38: 320-323.
http://dx.doi.org/10.1038/ng1732
PMid:16415884
Groenewoud MJ, Dekker JM, Fritsche A, Reiling E, et al. (2008). Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps. Diabetologia 51: 1659-1663.
http://dx.doi.org/10.1007/s00125-008-1083-z
PMid:18618095
Hertel JK, Johansson S, Raeder H, Midthjell K, et al. (2008). Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study). Diabetologia 51: 971-977.
http://dx.doi.org/10.1007/s00125-008-0982-3
PMid:18437351
Horikawa Y, Miyake K, Yasuda K, Enya M, et al. (2008). Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. J. Clin. Endocrinol. Metab. 93: 3136-3141.
http://dx.doi.org/10.1210/jc.2008-0452
PMid:18477659
Horikoshi M, Hara K, Ito C, Shojima N, et al. (2007). Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia 50: 2461-2466.
http://dx.doi.org/10.1007/s00125-007-0827-5
PMid:17928989
Kirchhoff K, Machicao F, Haupt A, Schafer SA, et al. (2008). Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia 51: 597-601.
http://dx.doi.org/10.1007/s00125-008-0926-y
PMid:18264689
Lee YH, Kang ES, Kim SH, Han SJ, et al. (2008). Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. J. Hum. Genet. 53: 991-998.
http://dx.doi.org/10.1007/s10038-008-0341-8
PMid:18991055
Lew J, Huang QQ, Qi Z, Winkfein RJ, et al. (1994). A brain-specific activator of cyclin-dependent kinase 5. Nature 371: 423-426.
http://dx.doi.org/10.1038/371423a0
PMid:8090222
Lewis JP, Palmer ND, Hicks PJ, Sale MM, et al. (2008). Association analysis in African Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes 57: 2220-2225.
http://dx.doi.org/10.2337/db07-1319
PMid:18443202 PMCid:2494685
Liu Y, Yu L, Zhang D, Chen Z, et al. (2008). Positive association between variations in CDKAL1 and type 2 diabetes in Han Chinese individuals. Diabetologia 51: 2134-2137.
http://dx.doi.org/10.1007/s00125-008-1141-6
PMid:18766326
Ng MC, Park KS, Oh B, Tam CH, et al. (2008). Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes 57: 2226-2233.
http://dx.doi.org/10.2337/db07-1583
PMid:18469204 PMCid:2494677
Omori S, Tanaka Y, Takahashi A, Hirose H, et al. (2008). Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 57: 791-795.
http://dx.doi.org/10.2337/db07-0979
PMid:18162508
Palmer ND, Goodarzi MO, Langefeld CD, Ziegler J, et al. (2008). Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study. Diabetes 57: 1093-1100.
http://dx.doi.org/10.2337/db07-1169
PMid:18252897
Pascoe L, Tura A, Patel SK, Ibrahim IM, et al. (2007). Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic β-cell function. Diabetes 56: 3101-3104.
http://dx.doi.org/10.2337/db07-0634
PMid:17804762
Ramachandran A, Snehalatha C, Latha E, Vijay V, et al. (1997). Rising prevalence of NIDDM in an urban population in India. Diabetologia 40: 232-237.
http://dx.doi.org/10.1007/s001250050668
PMid:9049486
Ramachandran A, Snehalatha C, Kapur A, Vijay V, et al. (2001). High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey. Diabetologia 44: 1094-1101.
http://dx.doi.org/10.1007/s001250100627
PMid:11596662
Rong R, Hanson RL, Ortiz D, Wiedrich C, et al. (2009). Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. Diabetes 58: 478-488.
http://dx.doi.org/10.2337/db08-0877
PMid:19008344 PMCid:2628623
Rosales JL and Lee KY (2006). Extraneuronal roles of cyclin-dependent kinase 5. Bioessays 28: 1023-1034.
http://dx.doi.org/10.1002/bies.20473
PMid:16998837
Sanghera DK, Ortega L, Han S, Singh J, et al. (2008). Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med. Genet. 9: 59.
http://dx.doi.org/10.1186/1471-2350-9-59
PMid:18598350 PMCid:2481250
Saxena R, Voight BF, Lyssenko V, Burtt NP, et al. (2007). Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316: 1331-1336.
http://dx.doi.org/10.1126/science.1142358
PMid:17463246
Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, et al. (2007). A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316: 1341-1345.
http://dx.doi.org/10.1126/science.1142382
PMid:17463248 PMCid:3214617
Stancáková A, Pihlajamaki J, Kuusisto J, Stefan N, et al. (2008). Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. J. Clin. Endocrinol. Metab. 93: 1924-1930.
http://dx.doi.org/10.1210/jc.2007-2218
PMid:18285412
Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, et al. (2007). A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat. Genet. 39: 770-775.
http://dx.doi.org/10.1038/ng2043
PMid:17460697
Tabara Y, Osawa H, Kawamoto R, Onuma H, et al. (2009). Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening. Diabetes 58: 493-498.
http://dx.doi.org/10.2337/db07-1785
PMid:19033397 PMCid:2628625
Takeuchi F, Serizawa M, Yamamoto K, Fujisawa T, et al. (2009). Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes 58: 1690-1699.
http://dx.doi.org/10.2337/db08-1494
PMid:19401414 PMCid:2699880
Teo YY, Sim X, Ong RT, Tan AK, et al. (2009). Singapore Genome Variation Project: a haplotype map of three Southeast Asian populations. Genome Res. 19: 2154-2162.
http://dx.doi.org/10.1101/gr.095000.109
PMid:19700652 PMCid:2775604
Tong Y, Lin Y, Zhang Y, Yang J, et al. (2009). Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis. BMC Med. Genet. 10: 15.
http://dx.doi.org/10.1186/1471-2350-10-15
PMid:19228405 PMCid:2653476
Ubeda M, Rukstalis JM and Habener JF (2006). Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity. J. Biol. Chem. 281: 28858-28864.
http://dx.doi.org/10.1074/jbc.M604690200
PMid:16887799
Wang K, Li T and Xiang H (1998). Study on the epidemiological characteristics of diabetes mellitus and IGT in China. Zhonghua Liu Xing. Bing. Xue. Za Zhi. 19: 282-285.
PMid:10322687
Wu Y, Li H, Loos RJ, Yu Z, et al. (2008). Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/ IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes 57: 2834-2842.
http://dx.doi.org/10.2337/db08-0047
PMid:18633108 PMCid:2551696
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, et al. (2007). Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316: 1336-1341.
http://dx.doi.org/10.1126/science.1142364
PMid:17463249