Publications
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“Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population”, vol. 13, pp. 3673-3680, 2014.
, “Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China”, vol. 11, pp. 4330-4341, 2012.
, Bestor TH (2000). The DNA methyltransferases of mammals. Hum. Mol. Genet. 9: 2395-2402.
http://dx.doi.org/10.1093/hmg/9.16.2395
PMid:11005794
Brenner C, Deplus R, Didelot C, Loriot A, et al. (2005). Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J. 24: 336-346.
http://dx.doi.org/10.1038/sj.emboj.7600509
PMid:15616584 PMCid:545804
Cai FF, Kohler C, Zhang B, Wang MH, et al. (2011). Epigenetic therapy for breast cancer. Int. J. Mol. Sci. 12: 4465-4487.
http://dx.doi.org/10.3390/ijms12074465
PMid:21845090 PMCid:3155363
Cebrian A, Pharoah PD, Ahmed S, Ropero S, et al. (2006). Genetic variants in epigenetic genes and breast cancer risk. Carcinogenesis 27: 1661-1669.
http://dx.doi.org/10.1093/carcin/bgi375
PMid:16501248
Deplus R, Brenner C, Burgers WA, Putmans P, et al. (2002). Dnmt3L is a transcriptional repressor that recruits histone deacetylase. Nucleic Acids Res. 30: 3831-3838.
http://dx.doi.org/10.1093/nar/gkf509
PMid:12202768 PMCid:137431
Easwaran HP, Schermelleh L, Leonhardt H and Cardoso MC (2004). Replication-independent chromatin loading of Dnmt1 during G2 and M phases. EMBO Rep. 5: 1181-1186.
http://dx.doi.org/10.1038/sj.embor.7400295
PMid:15550930 PMCid:1299190
Egger G, Liang G, Aparicio A and Jones PA (2004). Epigenetics in human disease and prospects for epigenetic therapy. Nature 429: 457-463.
http://dx.doi.org/10.1038/nature02625
PMid:15164071
Ehrlich M (2002). DNA methylation in cancer: too much, but also too little. Oncogene 21: 5400-5413.
http://dx.doi.org/10.1038/sj.onc.1205651
PMid:12154403
Esteller M, Silva JM, Dominguez G, Bonilla F, et al. (2000). Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J. Natl. Cancer Inst. 92: 564-569.
http://dx.doi.org/10.1093/jnci/92.7.564
PMid:10749912
Fan H, Liu D, Qiu X, Qiao F, et al. (2010). A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma. BMC Med. 8: 12.
http://dx.doi.org/10.1186/1741-7015-8-12
PMid:20128888 PMCid:2829483
Franke A, McGovern DP, Barrett JC, Wang K, et al. (2010). Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat. Genet. 42: 1118-1125.
http://dx.doi.org/10.1038/ng.717
PMid:21102463 PMCid:3299551
Fuks F, Burgers WA, Godin N, Kasai M, et al. (2001). Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J. 20: 2536-2544.
http://dx.doi.org/10.1093/emboj/20.10.2536
PMid:11350943 PMCid:125250
Goll MG, Kirpekar F, Maggert KA, Yoder JA, et al. (2006). Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science 311: 395-398.
http://dx.doi.org/10.1126/science.1120976
PMid:16424344
Gudbjartsson DF, Walters GB, Thorleifsson G, Stefansson H, et al. (2008). Many sequence variants affecting diversity of adult human height. Nat. Genet. 40: 609-615.
http://dx.doi.org/10.1038/ng.122
PMid:18391951
Haggarty P, Hoad G, Harris SE, Starr JM, et al. (2010). Human intelligence and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking. PLoS One 5: e11329.
http://dx.doi.org/10.1371/journal.pone.0011329
PMid:20593030 PMCid:2892514
Herman JG and Baylin SB (2003). Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med. 349: 2042-2054.
http://dx.doi.org/10.1056/NEJMra023075
PMid:14627790
Hu J, Fan H, Liu D, Zhang S, et al. (2010). DNMT3B promoter polymorphism and risk of gastric cancer. Dig. Dis. Sci. 55: 1011-1016.
http://dx.doi.org/10.1007/s10620-009-0831-3
PMid:19517237
Jemal A, Bray F, Center MM, Ferlay J, et al. (2011). Global cancer statistics. CA Cancer J. Clin. 61: 69-90.
http://dx.doi.org/10.3322/caac.20107
PMid:21296855
Jones PA and Baylin SB (2002). The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3: 415-428.
PMid:12042769
Kanai Y, Ushijima S, Nakanishi Y, Sakamoto M, et al. (2003). Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers. Cancer Lett. 192: 75-82.
http://dx.doi.org/10.1016/S0304-3835(02)00689-4
Kang ES, Park CW and Chung JH (2001). Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1. Biochem. Biophys. Res. Commun. 289: 862-868.
http://dx.doi.org/10.1006/bbrc.2001.6057
PMid:11735126
Kelemen LE, Sellers TA, Schildkraut JM, Cunningham JM, et al. (2008). Genetic variation in the one-carbon transfer pathway and ovarian cancer risk. Cancer Res. 68: 2498-2506.
http://dx.doi.org/10.1158/0008-5472.CAN-07-5165
PMid:18381459 PMCid:2786310
Kim GD, Ni J, Kelesoglu N, Roberts RJ, et al. (2002). Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. EMBO J. 21: 4183-4195.
http://dx.doi.org/10.1093/emboj/cdf401
PMid:12145218 PMCid:126147
Lee SJ, Jeon HS, Jang JS, Park SH, et al. (2005). DNMT3B polymorphisms and risk of primary lung cancer. Carcinogenesis 26: 403-409.
http://dx.doi.org/10.1093/carcin/bgh307
PMid:15528220
Lehnertz B, Ueda Y, Derijck AA, Braunschweig U, et al. (2003). Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr. Biol. 13: 1192-1200.
http://dx.doi.org/10.1016/S0960-9822(03)00432-9
“Differences in H3K4 trimethylation in in vivo and in vitro fertilization mouse preimplantation embryos”, vol. 11, pp. 1099-1108, 2012.
, Baqir S, Zhou Q, Renard JP and Smith LC (2002). Aberrant expression profile of imprinted genes in cloned mouse embryos reconstructed with ES cells treated with 5AzaC or TSA. Biol. Reprod. 66: 244-250.
Dey SK, Lim H, Das SK, Reese J, et al. (2004). Molecular cues to implantation. Endocr. Rev. 25: 341-373.
http://dx.doi.org/10.1210/er.2003-0020
PMid:15180948
Doherty AS, Mann MR, Tremblay KD, Bartolomei MS, et al. (2000). Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo. Biol. Reprod. 62: 1526-1535.
http://dx.doi.org/10.1095/biolreprod62.6.1526
PMid:10819752
Eissenberg JC and Shilatifard A (2010). Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev. Biol. 339: 240-249.
http://dx.doi.org/10.1016/j.ydbio.2009.08.017
PMid:19703438
Flanagan JF, Mi LZ, Chruszcz M, Cymborowski M, et al. (2005). Double chromodomains cooperate to recognize the methylated histone H3 tail. Nature 438: 1181-1185.
http://dx.doi.org/10.1038/nature04290
PMid:16372014
Fleming TP, Kwong WY, Porter R, Ursell E, et al. (2004). The embryo and its future. Biol. Reprod. 71: 1046-1054.
http://dx.doi.org/10.1095/biolreprod.104.030957
PMid:15215194
Glaser S, Lubitz S, Loveland KL, Ohbo K, et al. (2009). The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis. Epigenetics Chromatin 2: 5.
http://dx.doi.org/10.1186/1756-8935-2-5
Guillemette B, Drogaris P, Lin HH, Armstrong H, et al. (2011). H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation. PLoS Genet. 7: e1001354.
http://dx.doi.org/10.1371/journal.pgen.1001354
PMid:21483810 PMCid:3069113
Hamatani T, Carter MG, Sharov AA and Ko MS (2004). Dynamics of global gene expression changes during mouse preimplantation development. Dev. Cell 6: 117-131.
http://dx.doi.org/10.1016/S1534-5807(03)00373-3
Huang JC, Yan LY, Lei ZL, Miao YL, et al. (2007a). Changes in histone acetylation during postovulatory aging of mouse oocyte. Biol. Reprod. 77: 666-670.
http://dx.doi.org/10.1095/biolreprod.107.062703
PMid:17582009
Huang JC, Lei ZL, Shi LH, Miao YL, et al. (2007b). Comparison of histone modifications in in vivo and in vitro fertilization mouse embryos. Biochem. Biophys. Res. Commun. 354: 77-83.
http://dx.doi.org/10.1016/j.bbrc.2006.12.163
PMid:17210126
Kim JM, Ogura A, Nagata M and Aoki F (2002). Analysis of the mechanism for chromatin remodeling in embryos reconstructed by somatic nuclear transfer. Biol. Reprod. 67: 760-766.
http://dx.doi.org/10.1095/biolreprod.101.000612
PMid:12193382
Kim JM, Liu H, Tazaki M, Nagata M, et al. (2003). Changes in histone acetylation during mouse oocyte meiosis. J. Cell Biol. 162: 37-46.
http://dx.doi.org/10.1083/jcb.200303047
PMid:12835313 PMCid:2172711
Li L, Zheng P and Dean J (2010). Maternal control of early mouse development. Development 137: 859-870.
http://dx.doi.org/10.1242/dev.039487
PMid:20179092 PMCid:2834456
McLaren A (1971). Blastocysts in the mouse uterus: the effect of ovariectomy, progesterone and oestrogen. J. Endocrinol. 50: 515-526.
http://dx.doi.org/10.1677/joe.0.0500515
PMid:5558058
Murata K, Kouzarides T, Bannister AJ and Gurdon JB (2010). Histone H3 lysine 4 methylation is associated with the transcriptional reprogramming efficiency of somatic nuclei by oocytes. Epigenetics Chromatin 3: 4.
http://dx.doi.org/10.1186/1756-8935-3-4
Murray K (1964). The occurrence of epsilon-n-methyl lysine in histones. Biochemistry 3: 10-15.
http://dx.doi.org/10.1021/bi00889a003
PMid:14114491
Nagy A, Gertsenstei M, Vintersten K and Behringer R (2003). Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory Press, New York, 161-208.
Nightingale KP, Gendreizig S, White DA, Bradbury C, et al. (2007). Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation. J. Biol. Chem. 282: 4408-4416.
http://dx.doi.org/10.1074/jbc.M606773200
PMid:17166833
Ruthenburg AJ, Allis CD and Wysocka J (2007). Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol. Cell 25: 15-30.
http://dx.doi.org/10.1016/j.molcel.2006.12.014
PMid:17218268
Shi X, Hong T, Walter KL, Ewalt M, et al. (2006). ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature 442: 96-99.
PMid:16728974 PMCid:3089773
Shilatifard A (2008). Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation. Curr. Opin. Cell Biol. 20: 341-348.
http://dx.doi.org/10.1016/j.ceb.2008.03.019
PMid:18508253 PMCid:2504688
Strömstedt M, Keeney DS, Waterman MR, Paria BC, et al. (1996). Preimplantation mouse blastocysts fail to express CYP genes required for estrogen biosynthesis. Mol. Reprod. Dev. 43: 428-436.
http://dx.doi.org/10.1002/(SICI)1098-2795(199604)43:4<428::AID-MRD4>3.0.CO;2-R
Wysocka J, Swigut T, Xiao H, Milne TA, et al. (2006). A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature 442: 86-90.
PMid:16728976
Yamanaka K, Sugimura S, Wakai T, Kawahara M, et al. (2009). Acetylation level of histone H3 in early embryonic stages affects subsequent development of miniature pig somatic cell nuclear transfer embryos. J. Reprod. Dev. 55: 638-644.
http://dx.doi.org/10.1262/jrd.20245
PMid:19700928
Young LE and Fairburn HR (2000). Improving the safety of embryo technologies: possible role of genomic imprinting. Theriogenology 53: 627-648.
http://dx.doi.org/10.1016/S0093-691X(99)00263-0
Zhao Z, Fan L and Frick KM (2010). Epigenetic alterations regulate estradiol-induced enhancement of memory consolidation. Proc. Natl. Acad. Sci. U. S. A. 107: 5605-5610.
http://dx.doi.org/10.1073/pnas.0910578107
PMid:20212170 PMCid:2851775
“Genetic variants on 17q21 are associated with asthma in a Han Chinese population”, vol. 11, pp. 340-347, 2012.
, Bisgaard H, Bonnelykke K, Sleiman PM, Brasholt M, et al. (2009). Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood. Am. J. Respir. Crit. Care Med. 179: 179-185.
http://dx.doi.org/10.1164/rccm.200809-1436OC
PMid:19029000
Bouzigon E, Corda E, Aschard H, Dizier MH, et al. (2008). Effect of 17q21 variants and smoking exposure in early-onset asthma. N. Engl. J. Med. 359: 1985-1994.
http://dx.doi.org/10.1056/NEJMoa0806604
PMid:18923164
Eder W, Ege MJ and von Mutius E (2006). The asthma epidemic. N. Engl. J. Med. 355: 2226-2235.
http://dx.doi.org/10.1056/NEJMra054308
PMid:17124020
Flory JH, Sleiman PM, Christie JD, Annaiah K, et al. (2009). 17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry. J. Allergy Clin. Immunol. 124: 605-607.
http://dx.doi.org/10.1016/j.jaci.2009.05.047
PMid:19660801
Galanter J, Choudhry S, Eng C, Nazario S, et al. (2008). ORMDL3 gene is associated with asthma in three ethnically diverse populations. Am. J. Respir. Crit. Care Med. 177: 1194-1200.
http://dx.doi.org/10.1164/rccm.200711-1644OC
PMid:18310477 PMCid:2408437
Halapi E, Gudbjartsson DF, Jonsdottir GM, Bjornsdottir US, et al. (2010). A sequence variant on 17q21 is associated with age at onset and severity of asthma. Eur. J. Hum. Genet. 18: 902-908.
http://dx.doi.org/10.1038/ejhg.2010.38
PMid:20372189 PMCid:2987388
Hirota T, Harada M, Sakashita M, Doi S, et al. (2008). Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population. J. Allergy Clin. Immunol. 121: 769-770.
http://dx.doi.org/10.1016/j.jaci.2007.09.038
PMid:18155279
Hjelmqvist L, Tuson M, Marfany G, Herrero E, et al. (2002). ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Genome Biol. 3: RESEARCH0027.
Leung TF, Sy HY, Ng MC, Chan IH, et al. (2009). Asthma and atopy are associated with chromosome 17q21 markers in Chinese children. Allergy 64: 621-628.
http://dx.doi.org/10.1111/j.1398-9995.2008.01873.x
PMid:19175592
Li X, Yang XX, Hu NY, Sun JZ, et al. (2011). A risk-associated single nucleotide polymorphism of SMAD7 is common to colorectal, gastric, and lung cancers in a Han Chinese population. Mol. Biol. Rep. 38: 5093-5097.
http://dx.doi.org/10.1007/s11033-010-0656-3
PMid:21221812
Madore AM, Tremblay K, Hudson TJ and Laprise C (2008). Replication of an association between 17q21 SNPs and asthma in a French-Canadian familial collection. Hum. Genet. 123: 93-95.
http://dx.doi.org/10.1007/s00439-007-0444-x
PMid:17992541
Moffatt MF, Kabesch M, Liang L, Dixon AL, et al. (2007). Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 448: 470-473.
http://dx.doi.org/10.1038/nature06014
PMid:17611496
Ober C and Hoffjan S (2006). Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun. 7: 95-100.
http://dx.doi.org/10.1038/sj.gene.6364284
PMid:16395390
Sleiman PM, Annaiah K, Imielinski M, Bradfield JP, et al. (2008). ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry. J. Allergy Clin. Immunol. 122: 1225-1227.
http://dx.doi.org/10.1016/j.jaci.2008.06.041
PMid:18760456
Tavendale R, MacGregor DF, Mukhopadhyay S and Palmer CN (2008). A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications. J. Allergy Clin. Immunol. 121: 860-863.
http://dx.doi.org/10.1016/j.jaci.2008.01.015
PMid:18395550
Wjst M (2008). ORMDL3 - guilt by association? Clin. Exp. Allergy 38: 1579-1581.
http://dx.doi.org/10.1111/j.1365-2222.2008.03086.x
Wu H, Romieu I, Sienra-Monge JJ, Li H, et al. (2009). Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma. Allergy 64: 629-635.
http://dx.doi.org/10.1111/j.1398-9995.2008.01912.x
PMid:19133921 PMCid:2697826