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2016
T. Xue and Lu, Z. N., Association between the polymorphisms in the ATP-binding cassette genes ABCB1 and ABCC2 and the risk of drug-resistant epilepsy in a Chinese Han population, vol. 15, no. 4, p. -, 2016.
Conflicts of interestThe authors declare no conflict of interest.ACKNOWLEDGMENTSResearch supported by grants from the Health and Family Planning Commission of Hubei Province Scientific Research Project (#WJ2015MA007) and the Wuhan Science and Technology Bureau Scientific Research Project (#2015060101010047).REFERENCESAkamine Y, Yasui-Furukori N, Ieiri I, Uno T, et al (2012). Psychotropic drug-drug interactions involving P-glycoprotein. CNS Drugs 26: 959-973. http://dx.doi.org/10.1007/s40263-012-0008-z Begley DJ, et al (2004). ABC transporters and the blood-brain barrier. Curr. Pharm. Des. 10: 1295-1312. http://dx.doi.org/10.2174/1381612043384844 Escalante-Santiago D, Feria-Romero IA, Ribas-Aparicio RM, Rayo-Mares D, et al (2014). MDR-1 and MRP2 gene polymorphisms in Mexican epileptic pediatric patients with complex partial seizures. Front. Neurol. 5: 184. http://dx.doi.org/10.3389/fneur.2014.00184 Friedberg EC, et al (2003). DNA damage and repair. Nature 421: 436-440. http://dx.doi.org/10.1038/nature01408 Giussani G, Canelli V, Bianchi E, Erba G, EPIRES Groupet al (2016). Long-term prognosis of epilepsy, prognostic patterns and drug resistance: a population-based study. Eur. J. Neurol. 23: 1218-1227. http://dx.doi.org/10.1111/ene.13005 Glauser TA, Pippenger CE, et al (2000). Controversies in blood-level monitoring: reexamining its role in the treatment of epilepsy. Epilepsia 41 (Suppl 8): S6-S15. http://dx.doi.org/10.1111/j.1528-1157.2000.tb02950.x Guo Y, Yan KP, Qu Q, Qu J, et al (2015). Common variants of KCNJ10 are associated with susceptibility and anti-epileptic drug resistance in Chinese genetic generalized epilepsies. PLoS One 10: e0124896. http://dx.doi.org/10.1371/journal.pone.0124896 Hilger E, Reinthaler EM, Stogmann E, Hotzy C, et al (2012). Lack of association between ABCC2 gene variants and treatment response in epilepsy. Pharmacogenomics 13: 185-190. http://dx.doi.org/10.2217/pgs.11.143 Huang C, Feng L, Li YH, Wang Y, et al (2016). Clinical features and prognosis of epilepsy in the elderly in western China. Seizure 38: 26-31. http://dx.doi.org/10.1016/j.seizure.2016.03.011 Keangpraphun T, Towanabut S, Chinvarun Y, Kijsanayotin P, et al (2015). Association of ABCB1 C3435T polymorphism with phenobarbital resistance in Thai patients with epilepsy. J. Clin. Pharm. Ther. 40: 315-319. http://dx.doi.org/10.1111/jcpt.12263 König J, Müller F, Fromm MF, et al (2013). Transporters and drug-drug interactions: important determinants of drug disposition and effects. Pharmacol. Rev. 65: 944-966. http://dx.doi.org/10.1124/pr.113.007518 Kwan P, Wong V, Ng PW, Lui CH, et al (2011). Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy. Pharmacogenomics 12: 319-325. http://dx.doi.org/10.2217/pgs.10.183 Lazarowski A, Czornyj L, et al (2011). Potential role of multidrug resistant proteins in refractory epilepsy and antiepileptic drugs interactions. Drug Metabol. Drug Interact. 26: 21-26. http://dx.doi.org/10.1515/dmdi.2011.006 Li SX, Liu YY, Wang QB, et al (2015). ABCB1 gene C3435T polymorphism and drug resistance in epilepsy: evidence based on 8,604 subjects. Med. Sci. Monit. 21: 861-868. http://dx.doi.org/10.12659/MSM.894023 Ma CL, Wu XY, Zheng J, Wu ZY, et al (2014). Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy. Pharmacogenomics 15: 1323-1336. http://dx.doi.org/10.2217/pgs.14.89 Nies AT, Jedlitschky G, König J, Herold-Mende C, et al (2004). Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain. Neuroscience 129: 349-360. http://dx.doi.org/10.1016/j.neuroscience.2004.07.051 Pi X, Zhou L, Cui L, Liu A, et al (2014). Prevalence and clinical characteristics of active epilepsy in southern Han Chinese. Seizure 23: 636-640. http://dx.doi.org/10.1016/j.seizure.2014.05.002 Qu J, Zhou BT, Yin JY, Xu XJ, et al (2012). ABCC2 polymorphisms and haplotype are associated with drug resistance in Chinese epileptic patients. CNS Neurosci. Ther. 18: 647-651. http://dx.doi.org/10.1111/j.1755-5949.2012.00336.x Qu J, Yang ZQ, Zhang Y, Mao CX, et al (2015). Common variants of ATP1A3 but not ATP1A2 are associated with Chinese genetic generalized epilepsies. J. Neurol. Sci. 354: 56-62. http://dx.doi.org/10.1016/j.jns.2015.04.045 Seo T, Ishitsu T, Oniki K, Abe T, et al (2008). ABCC2 haplotype is not associated with drug-resistant epilepsy. J. Pharm. Pharmacol. 60: 631-635. http://dx.doi.org/10.1211/jpp.60.5.0009 Sporis D, Bozina N, Basić S, Lovrić M, et al (2013). Lack of association between polymorphism in ABCC2 gene and response to antiepileptic drug treatment in Croatian patients with epilepsy. Coll. Antropol. 37: 41-45. Subenthiran S, Abdullah NR, Joseph JP, Muniandy PK, et al (2013a). Linkage disequilibrium between polymorphisms of ABCB1 and ABCC2 to predict the treatment outcome of Malaysians with complex partial seizures on treatment with carbamazepine mono-therapy at the Kuala Lumpur Hospital. PLoS One 8: e64827. http://dx.doi.org/10.1371/journal.pone.0064827 Subenthiran S, Abdullah NR, Muniandy PK, Joseph JP, et al (2013b). G2677T polymorphism can predict treatment outcome of Malaysians with complex partial seizures being treated with Carbamazepine. Genet. Mol. Res. 12: 5937-5944. http://dx.doi.org/10.4238/2013.November.26.3 Tang F, Zhu G, Jiao Z, Ma C, et al (2014). The effects of medication education and behavioral intervention on Chinese patients with epilepsy. Epilepsy Behav. 37: 157-164. http://dx.doi.org/10.1016/j.yebeh.2014.05.017 Ufer M, Mosyagin I, Muhle H, Jacobsen T, et al (2009). Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy. Pharmacogenet. Genomics 19: 353-362. http://dx.doi.org/10.1097/FPC.0b013e328329940b Urry DW, Urry KD, Szaflarski W, Nowicki M, et al (2009). Function and frustration of multi-drug ABC exporter protein and design of model proteins for drug delivery using protein hydration thermodynamics. Curr. Pharm. Des. 15: 2833-2867. http://dx.doi.org/10.2174/138161209788923787 Wang Y, Tang L, Pan J, Li J, et al (2015). The recessive model of MRP2 G1249A polymorphism decrease the risk of drug-resistant in Asian Epilepsy: a systematic review and meta-analysis. Epilepsy Res. 112: 56-63. http://dx.doi.org/10.1016/j.eplepsyres.2015.02.007 Yu L, Liao WP, Yi YH, Qiu G, et al (2015). ABCB1 G2677T/A polymorphism is associated with the risk of drug-resistant epilepsy in Asians. Epilepsy Res. 115: 100-108. http://dx.doi.org/10.1016/j.eplepsyres.2015.05.015 Zhou B, Huang Y, Wang J, Zou Z, et al (2014). The aetiology of convulsive status epilepticus: a study of 258 cases in Western China. Seizure 23: 717-721. http://dx.doi.org/10.1016/j.seizure.2014.05.015 Zhou L, Cao Y, Long H, Long L, et al (2015). ABCB1, ABCC2, SCN1A, SCN2A, GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population. Pharmazie 70: 416-420. Zimprich F, Sunder-Plassmann R, Stogmann E, Gleiss A, et al (2004). Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy. Neurology 63: 1087-1089. http://dx.doi.org/10.1212/01.WNL.0000141021.42763.F6    
L. Ma, Lu, Z. N., Ma, L., and Lu, Z. N., Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease, vol. 15, p. -, 2016.
L. Ma, Lu, Z. N., Ma, L., and Lu, Z. N., Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer's disease, vol. 15, p. -, 2016.