Publications

Found 18 results
Filters: Author is J.R. Pesarini  [Clear All Filters]
2016
M. F. Magosso, Carvalho, P. C., Shneider, B. U. C., Pessatto, L. R., Pesarini, J. R., Silva, P. V. B., Correa, W. A., Kassuya, C. A. L., Muzzi, R. M., Oliveira, R. J., Magosso, M. F., Carvalho, P. C., Shneider, B. U. C., Pessatto, L. R., Pesarini, J. R., Silva, P. V. B., Correa, W. A., Kassuya, C. A. L., Muzzi, R. M., and Oliveira, R. J., “Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide”, vol. 15, p. -, 2016.
M. F. Magosso, Carvalho, P. C., Shneider, B. U. C., Pessatto, L. R., Pesarini, J. R., Silva, P. V. B., Correa, W. A., Kassuya, C. A. L., Muzzi, R. M., Oliveira, R. J., Magosso, M. F., Carvalho, P. C., Shneider, B. U. C., Pessatto, L. R., Pesarini, J. R., Silva, P. V. B., Correa, W. A., Kassuya, C. A. L., Muzzi, R. M., and Oliveira, R. J., “Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide”, vol. 15, p. -, 2016.
L. C. Hermeto, DeRossi, R., Oliveira, R. J., Pesarini, J. R., Antoniolli-Silva, A. C. M. B., Jardim, P. H. A., Santana, Á. E., Deffune, E., Rinaldi, J. C., Justulin, L. A., Hermeto, L. C., DeRossi, R., Oliveira, R. J., Pesarini, J. R., Antoniolli-Silva, A. C. M. B., Jardim, P. H. A., Santana, Á. E., Deffune, E., Rinaldi, J. C., and Justulin, L. A., “Effects of intra-articular injection of mesenchymal stem cells associated with platelet-rich plasma in a rabbit model of osteoarthritis”, vol. 15, p. -, 2016.
L. C. Hermeto, DeRossi, R., Oliveira, R. J., Pesarini, J. R., Antoniolli-Silva, A. C. M. B., Jardim, P. H. A., Santana, Á. E., Deffune, E., Rinaldi, J. C., Justulin, L. A., Hermeto, L. C., DeRossi, R., Oliveira, R. J., Pesarini, J. R., Antoniolli-Silva, A. C. M. B., Jardim, P. H. A., Santana, Á. E., Deffune, E., Rinaldi, J. C., and Justulin, L. A., “Effects of intra-articular injection of mesenchymal stem cells associated with platelet-rich plasma in a rabbit model of osteoarthritis”, vol. 15, p. -, 2016.
R. J. Oliveira, de David, N., Pesarini, J. R., Nogueira, T. D., Kassuya, C. A. L., Strapasson, R. L. B., Stefanello, M. E. A., Monreal, A. C. D., Matuo, R., Antoniolli-Silva, A. C. M. B., Oliveira, R. J., de David, N., Pesarini, J. R., Nogueira, T. D., Kassuya, C. A. L., Strapasson, R. L. B., Stefanello, M. E. A., Monreal, A. C. D., Matuo, R., Antoniolli-Silva, A. C. M. B., Oliveira, R. J., de David, N., Pesarini, J. R., Nogueira, T. D., Kassuya, C. A. L., Strapasson, R. L. B., Stefanello, M. E. A., Monreal, A. C. D., Matuo, R., and Antoniolli-Silva, A. C. M. B., “Moquiniastrum polymorphum subsp floccosum extract: screening for mutagenic and antimutagenic activity”, vol. 15, no. 4, p. -, 2016.
Conflicts of interest The authors declare no conflicts of interest. ACKNOWLEDGMENTS Research supported by FUNDECT (Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul), CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico). REFERENCES Bohlmann F, Zdero C, Schmeda-Hirschmann G, Jakupovic J, et al (1986). Dimeric guainolides and other constituents from Gochnatia species. Phytochemistry 44: 1175-1178. http://dx.doi.org/10.1016/S0031-9422(00)81575-7 Bueno NR, Castilho RO, Costa RB, Pott A, et al (2005). Medicinal plants used by the Kaiowá and Guarani indigenous populations in the Caarapó reserve, Mato Grosso do Sul, Brazil. Acta Bot. Bras. 19: 39-44. http://dx.doi.org/10.1590/S0102-33062005000100005 Cantero WB, Takahachi NA, Mauro MO, Pesarini JR, et al (2015). Genomic lesions and colorectal carcinogenesis: the effects of protein-calorie restriction and inulin supplementation on deficiency statuses. Genet. Mol. Res. 14: 2422-2435. http://dx.doi.org/10.4238/2015.March.27.27 Catalan CAN, Vega MI, Lopez ME, Cuenca M del R, et al (2003). Coumarins and a kaurane from Gochnatia polymorpha ssp. Polymorpha from Paraguay. Biochem. Syst. Ecol. 31: 417-422. http://dx.doi.org/10.1016/S0305-1978(02)00163-1 Cooper EL, et al (2004). Drug discovery, CAM and natural products. Evid. Based Complement. Alternat. Med. 1: 215-217. http://dx.doi.org/10.1093/ecam/neh032 Cragg GM, Newman DJ, et al (2013). Natural products: a continuing source of novel drug leads. Biochim. Biophys. Acta 1830: 3670-3695. http://dx.doi.org/10.1016/j.bbagen.2013.02.008 David Nd, Mauro MdeO, Gonçalves CA, Pesarini JR, et al (2014). Gochnatia polymorpha ssp. floccosa: bioprospecting of an anti-inflammatory phytotherapy for use during pregnancy. J. Ethnopharmacol. 154: 370-379. http://dx.doi.org/10.1016/j.jep.2014.04.005 Farias ACM, Da Silva JR, Tomassini TCB, et al (1984). Constituents of Mochinea polymorpha. J. Nat. Prod. 47: 363-364. http://dx.doi.org/10.1021/np50032a021 Fedel-Miyasato LES, Formagio ASN, Auharek SA, Kassuya CAL, et al (2014a). Antigenotoxic and antimutagenic effects of Schinus terebinthifolius Raddi in Allium cepa and Swiss mice: a comparative study. Genet. Mol. Res. 13: 3411-3425. http://dx.doi.org/10.4238/2014.April.30.2 Fedel-Miyasato LES, Kassuya CAL, Auharek SA, Formagio ASN, et al (2014b). Evaluation of anti-inflammatory, immunomodulatory, chemopreventive and wound healing potentials from Schinus terebinthifolius methanolic extract. Braz. J. Pharmacog. 24: 565-575. Felicidade I, Lima JD, Pesarini JR, Monreal ACD, et al (2014a). Mutagenic and antimutagenic effects of aqueous extract of rosemary (Rosmarinus officinalis L.) on meristematic cells of Allium cepa. Genet. Mol. Res. 13: 9986-9996. http://dx.doi.org/10.4238/2014.November.28.3 Felicidade I, Lima JD, Pesarini JR, Monreal ACD, et al (2014b). Mutagenic and antimutagenic effects of crude hydroalcoholic extract of rosemary (Rosmarinus officinalis L.) on cultured meristematic cells Allium cepa. VRI Phytomedicine 2: 30-39. Fiskesjö G, et al (1993). The Allium test in wastewater monitoring. Environ. Toxicol. 8: 291-298. Leme DM, Marin-Morales MA, et al (2009). Allium cepa test in environmental monitoring: a review on its application. Mutat. Res. 682: 71-81. http://dx.doi.org/10.1016/j.mrrev.2009.06.002 López ME, Giordano OS, López LA, et al (2002). Sesquiterpene lactone dehydroleucodine selectively induces transient arrest in G2 in Allium cepa root meristematic cells. Protoplasma 219: 82-88. http://dx.doi.org/10.1007/s007090200008 Magosso MF, Carvalho PC, Shneider BU, Pessatto LR, et al (2016). Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide. Genet. Mol. Res. 15. http://dx.doi.org/10.4238/gmr.15027816 Manoharan K, Banerjee MR, et al (1985). beta-Carotene reduces sister chromatid exchanges induced by chemical carcinogens in mouse mammary cells in organ culture. Cell Biol. Int. Rep. 9: 783-789. http://dx.doi.org/10.1016/0309-1651(85)90096-7 Martello MD, David N, Matuo R, Carvalho PC, et al (2016). Campomanesia adamantium extract induces DNA damage, apoptosis, and affects cyclophosphamide metabolism. Genet. Mol. Res. 15. http://dx.doi.org/10.4238/gmr.15027678 Martins GG, Lívero FA, Stolf AM, Kopruszinski CM, et al (2015). Sesquiterpene lactones of Moquiniastrum polymorphum subsp. floccosum have antineoplastic effects in Walker-256 tumor-bearing rats. Chem. Biol. Interact. 228: 46-56. http://dx.doi.org/10.1016/j.cbi.2015.01.018 Mauro MO, Pesarini JR, Marin-Morales MA, Monreal MT, et al (2014). Evaluation of the antimutagenic activity and mode of action of the fructooligosaccharide inulin in the meristematic cells of Allium cepa culture. Genet. Mol. Res. 13: 4808-4819. http://dx.doi.org/10.4238/2014.February.14.14 Moreira AS, Spitzer V, Schapoval EE, Schenkel EP, et al (2000). Antiinflammatory activity of extracts and fractions from the leaves of Gochnatia polymorpha. Phytother. Res. 14: 638-640. http://dx.doi.org/10.1002/1099-1573(200012)14:8<638::AID-PTR681>3.0.CO;2-Q Nantes CI, Pesarini JR, Mauro MO, Monreal ACD, et al (2014). Evaluation of the antimutagenic activity and mode of action of carrageenan fiber in cultured meristematic cells of Allium cepa. Genet. Mol. Res. 13: 9523-9532. http://dx.doi.org/10.4238/2014.November.12.1 Navarro SD, Mauro MO, Pesarini JR, Ogo FM, et al (2015). Resistant starch: a functional food that prevents DNA damage and chemical carcinogenesis. Genet. Mol. Res. 14: 1679-1691. http://dx.doi.org/10.4238/2015.March.6.14 Oliveira RJ, Ribeiro LR, da Silva AF, Matuo R, et al (2006). Evaluation of antimutagenic activity and mechanisms of action of β-glucan from barley, in CHO-k1 and HTC cell lines using the micronucleus test. Toxicol. In Vitro 20: 1225-1233. http://dx.doi.org/10.1016/j.tiv.2006.04.001 Oliveira RJ, Matuo R, da Silva AF, Matiazi HJ, et al (2007). Protective effect of β-glucan extracted from Saccharomyces cerevisiae, against DNA damage and cytotoxicity in wild-type (k1) and repair-deficient (xrs5) CHO cells. Toxicol. In Vitro 21: 41-52. http://dx.doi.org/10.1016/j.tiv.2006.07.018 Oliveira RJ, Fronza LS, Honda RE, Aquino MT, et al (2015). Effects of Avena sativa L. supplementation on ponderal development, reproductive performance and embryo-fetal development of pregnant rats exposed to cyclophosphamide. PECIBES 1: 1-8. Piornedo R dos R, de Souza P, Stefanello MÉ, Strapasson RL, et al (2011). Anti-inflammatory activity of extracts and 11,13-dihydrozaluzanin C from Gochnatia polymorpha ssp. floccosa trunk bark in mice. J. Ethnopharmacol. 133: 1077-1084. http://dx.doi.org/10.1016/j.jep.2010.11.040 Rang HP, Dale MM, Ritter JM, Flower RJ, et al. (2012). Rang & Dale's pharmacology. 7th edn. Churchill Livingstone, Edinburgh. Rank J, Nielsen MH, et al (1997). Allium cepa anaphase-telophase root tip chromosome aberration assay on N-methyl-N-nitrosourea, maleic hydrazide, sodium azide, and ethyl methanesulfonate. Mutat. Res. 390: 121-127. http://dx.doi.org/10.1016/S0165-1218(97)00008-6 Rocha RS, Kassuya CAL, Formagio AS, Mauro M de O, et al (2016). Analysis of the anti-inflammatory and chemopreventive potential and description of the antimutagenic mode of action of the Annona crassiflora methanolic extract. Pharm. Biol. 54: 35-47. http://dx.doi.org/10.3109/13880209.2015.1014567 Roque N (2014). Moquiniastrum. Lista de espécies da flora do Brasil. Jardim Botânico do Rio de Janeiro. Available at [http://floradobrasil.jbrj.gov.br/jabot/floradobrasil/FB130872]. Accessed June 28, 2016. Sacilotto ACB, Vichnewski W, Herz W, et al (1997). Ent-kaurene diterpenes from Gochnatia polymorpha var. polymorpha. Phytochemistry 44: 659-661. http://dx.doi.org/10.1016/S0031-9422(96)00601-2 Schlemper V, Freitas SA, Schlemper SEM, et al (2011). Antispasmodic effects of hydroalcoholic extract from Gochnatia polymorpha ssp. floccosa in the guinea pig ileum. Res. J. Med. Plant 5: 288-294. http://dx.doi.org/10.3923/rjmp.2011.288.294 Schneider BUC, Meza A, Beatriz A, Pesarini JR, et al (2016). Cardanol: toxicogenetic assessment and its effects when combined with cyclophosphamide. Genet. Mol. Biol. 39: 279-289. http://dx.doi.org/10.1590/1678-4685-GMB-2015-0170 Snustad P and Simmons MJ (2013). Fundamentos de genética. 6th edn. Guanabara Koogan, Rio de Janeiro. Strapasson RL, Cervi AC, Carvalho JE, Ruiz AL, et al (2012). Bioactivity-guided isolation of cytotoxic sesquiterpene lactones of Gochnatia polymorpha ssp. floccosa. Phytother. Res. 26: 1053-1056. http://dx.doi.org/10.1002/ptr.3693 Zar HJ, Udwadia ZF, et al (2013). Advances in tuberculosis 2011-2012. Thorax 68: 283-287. http://dx.doi.org/10.1136/thoraxjnl-2012-203127
R. J. Oliveira, de David, N., Pesarini, J. R., Nogueira, T. D., Kassuya, C. A. L., Strapasson, R. L. B., Stefanello, M. E. A., Monreal, A. C. D., Matuo, R., Antoniolli-Silva, A. C. M. B., Oliveira, R. J., de David, N., Pesarini, J. R., Nogueira, T. D., Kassuya, C. A. L., Strapasson, R. L. B., Stefanello, M. E. A., Monreal, A. C. D., Matuo, R., Antoniolli-Silva, A. C. M. B., Oliveira, R. J., de David, N., Pesarini, J. R., Nogueira, T. D., Kassuya, C. A. L., Strapasson, R. L. B., Stefanello, M. E. A., Monreal, A. C. D., Matuo, R., and Antoniolli-Silva, A. C. M. B., “Moquiniastrum polymorphum subsp floccosum extract: screening for mutagenic and antimutagenic activity”, vol. 15, no. 4, p. -, 2016.
Conflicts of interest The authors declare no conflicts of interest. ACKNOWLEDGMENTS Research supported by FUNDECT (Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul), CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico). REFERENCES Bohlmann F, Zdero C, Schmeda-Hirschmann G, Jakupovic J, et al (1986). Dimeric guainolides and other constituents from Gochnatia species. Phytochemistry 44: 1175-1178. http://dx.doi.org/10.1016/S0031-9422(00)81575-7 Bueno NR, Castilho RO, Costa RB, Pott A, et al (2005). Medicinal plants used by the Kaiowá and Guarani indigenous populations in the Caarapó reserve, Mato Grosso do Sul, Brazil. Acta Bot. Bras. 19: 39-44. http://dx.doi.org/10.1590/S0102-33062005000100005 Cantero WB, Takahachi NA, Mauro MO, Pesarini JR, et al (2015). Genomic lesions and colorectal carcinogenesis: the effects of protein-calorie restriction and inulin supplementation on deficiency statuses. Genet. Mol. Res. 14: 2422-2435. http://dx.doi.org/10.4238/2015.March.27.27 Catalan CAN, Vega MI, Lopez ME, Cuenca M del R, et al (2003). Coumarins and a kaurane from Gochnatia polymorpha ssp. Polymorpha from Paraguay. Biochem. Syst. Ecol. 31: 417-422. http://dx.doi.org/10.1016/S0305-1978(02)00163-1 Cooper EL, et al (2004). Drug discovery, CAM and natural products. Evid. Based Complement. Alternat. Med. 1: 215-217. http://dx.doi.org/10.1093/ecam/neh032 Cragg GM, Newman DJ, et al (2013). Natural products: a continuing source of novel drug leads. Biochim. Biophys. Acta 1830: 3670-3695. http://dx.doi.org/10.1016/j.bbagen.2013.02.008 David Nd, Mauro MdeO, Gonçalves CA, Pesarini JR, et al (2014). Gochnatia polymorpha ssp. floccosa: bioprospecting of an anti-inflammatory phytotherapy for use during pregnancy. J. Ethnopharmacol. 154: 370-379. http://dx.doi.org/10.1016/j.jep.2014.04.005 Farias ACM, Da Silva JR, Tomassini TCB, et al (1984). Constituents of Mochinea polymorpha. J. Nat. Prod. 47: 363-364. http://dx.doi.org/10.1021/np50032a021 Fedel-Miyasato LES, Formagio ASN, Auharek SA, Kassuya CAL, et al (2014a). Antigenotoxic and antimutagenic effects of Schinus terebinthifolius Raddi in Allium cepa and Swiss mice: a comparative study. Genet. Mol. Res. 13: 3411-3425. http://dx.doi.org/10.4238/2014.April.30.2 Fedel-Miyasato LES, Kassuya CAL, Auharek SA, Formagio ASN, et al (2014b). Evaluation of anti-inflammatory, immunomodulatory, chemopreventive and wound healing potentials from Schinus terebinthifolius methanolic extract. Braz. J. Pharmacog. 24: 565-575. Felicidade I, Lima JD, Pesarini JR, Monreal ACD, et al (2014a). Mutagenic and antimutagenic effects of aqueous extract of rosemary (Rosmarinus officinalis L.) on meristematic cells of Allium cepa. Genet. Mol. Res. 13: 9986-9996. http://dx.doi.org/10.4238/2014.November.28.3 Felicidade I, Lima JD, Pesarini JR, Monreal ACD, et al (2014b). Mutagenic and antimutagenic effects of crude hydroalcoholic extract of rosemary (Rosmarinus officinalis L.) on cultured meristematic cells Allium cepa. VRI Phytomedicine 2: 30-39. Fiskesjö G, et al (1993). The Allium test in wastewater monitoring. Environ. Toxicol. 8: 291-298. Leme DM, Marin-Morales MA, et al (2009). Allium cepa test in environmental monitoring: a review on its application. Mutat. Res. 682: 71-81. http://dx.doi.org/10.1016/j.mrrev.2009.06.002 López ME, Giordano OS, López LA, et al (2002). Sesquiterpene lactone dehydroleucodine selectively induces transient arrest in G2 in Allium cepa root meristematic cells. Protoplasma 219: 82-88. http://dx.doi.org/10.1007/s007090200008 Magosso MF, Carvalho PC, Shneider BU, Pessatto LR, et al (2016). Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide. Genet. Mol. Res. 15. http://dx.doi.org/10.4238/gmr.15027816 Manoharan K, Banerjee MR, et al (1985). beta-Carotene reduces sister chromatid exchanges induced by chemical carcinogens in mouse mammary cells in organ culture. Cell Biol. Int. Rep. 9: 783-789. http://dx.doi.org/10.1016/0309-1651(85)90096-7 Martello MD, David N, Matuo R, Carvalho PC, et al (2016). Campomanesia adamantium extract induces DNA damage, apoptosis, and affects cyclophosphamide metabolism. Genet. Mol. Res. 15. http://dx.doi.org/10.4238/gmr.15027678 Martins GG, Lívero FA, Stolf AM, Kopruszinski CM, et al (2015). Sesquiterpene lactones of Moquiniastrum polymorphum subsp. floccosum have antineoplastic effects in Walker-256 tumor-bearing rats. Chem. Biol. Interact. 228: 46-56. http://dx.doi.org/10.1016/j.cbi.2015.01.018 Mauro MO, Pesarini JR, Marin-Morales MA, Monreal MT, et al (2014). Evaluation of the antimutagenic activity and mode of action of the fructooligosaccharide inulin in the meristematic cells of Allium cepa culture. Genet. Mol. Res. 13: 4808-4819. http://dx.doi.org/10.4238/2014.February.14.14 Moreira AS, Spitzer V, Schapoval EE, Schenkel EP, et al (2000). Antiinflammatory activity of extracts and fractions from the leaves of Gochnatia polymorpha. Phytother. Res. 14: 638-640. http://dx.doi.org/10.1002/1099-1573(200012)14:8<638::AID-PTR681>3.0.CO;2-Q Nantes CI, Pesarini JR, Mauro MO, Monreal ACD, et al (2014). Evaluation of the antimutagenic activity and mode of action of carrageenan fiber in cultured meristematic cells of Allium cepa. Genet. Mol. Res. 13: 9523-9532. http://dx.doi.org/10.4238/2014.November.12.1 Navarro SD, Mauro MO, Pesarini JR, Ogo FM, et al (2015). Resistant starch: a functional food that prevents DNA damage and chemical carcinogenesis. Genet. Mol. Res. 14: 1679-1691. http://dx.doi.org/10.4238/2015.March.6.14 Oliveira RJ, Ribeiro LR, da Silva AF, Matuo R, et al (2006). Evaluation of antimutagenic activity and mechanisms of action of β-glucan from barley, in CHO-k1 and HTC cell lines using the micronucleus test. Toxicol. In Vitro 20: 1225-1233. http://dx.doi.org/10.1016/j.tiv.2006.04.001 Oliveira RJ, Matuo R, da Silva AF, Matiazi HJ, et al (2007). Protective effect of β-glucan extracted from Saccharomyces cerevisiae, against DNA damage and cytotoxicity in wild-type (k1) and repair-deficient (xrs5) CHO cells. Toxicol. In Vitro 21: 41-52. http://dx.doi.org/10.1016/j.tiv.2006.07.018 Oliveira RJ, Fronza LS, Honda RE, Aquino MT, et al (2015). Effects of Avena sativa L. supplementation on ponderal development, reproductive performance and embryo-fetal development of pregnant rats exposed to cyclophosphamide. PECIBES 1: 1-8. Piornedo R dos R, de Souza P, Stefanello MÉ, Strapasson RL, et al (2011). Anti-inflammatory activity of extracts and 11,13-dihydrozaluzanin C from Gochnatia polymorpha ssp. floccosa trunk bark in mice. J. Ethnopharmacol. 133: 1077-1084. http://dx.doi.org/10.1016/j.jep.2010.11.040 Rang HP, Dale MM, Ritter JM, Flower RJ, et al. (2012). Rang & Dale's pharmacology. 7th edn. Churchill Livingstone, Edinburgh. Rank J, Nielsen MH, et al (1997). Allium cepa anaphase-telophase root tip chromosome aberration assay on N-methyl-N-nitrosourea, maleic hydrazide, sodium azide, and ethyl methanesulfonate. Mutat. Res. 390: 121-127. http://dx.doi.org/10.1016/S0165-1218(97)00008-6 Rocha RS, Kassuya CAL, Formagio AS, Mauro M de O, et al (2016). Analysis of the anti-inflammatory and chemopreventive potential and description of the antimutagenic mode of action of the Annona crassiflora methanolic extract. Pharm. Biol. 54: 35-47. http://dx.doi.org/10.3109/13880209.2015.1014567 Roque N (2014). Moquiniastrum. Lista de espécies da flora do Brasil. Jardim Botânico do Rio de Janeiro. Available at [http://floradobrasil.jbrj.gov.br/jabot/floradobrasil/FB130872]. Accessed June 28, 2016. Sacilotto ACB, Vichnewski W, Herz W, et al (1997). Ent-kaurene diterpenes from Gochnatia polymorpha var. polymorpha. Phytochemistry 44: 659-661. http://dx.doi.org/10.1016/S0031-9422(96)00601-2 Schlemper V, Freitas SA, Schlemper SEM, et al (2011). Antispasmodic effects of hydroalcoholic extract from Gochnatia polymorpha ssp. floccosa in the guinea pig ileum. Res. J. Med. Plant 5: 288-294. http://dx.doi.org/10.3923/rjmp.2011.288.294 Schneider BUC, Meza A, Beatriz A, Pesarini JR, et al (2016). Cardanol: toxicogenetic assessment and its effects when combined with cyclophosphamide. Genet. Mol. Biol. 39: 279-289. http://dx.doi.org/10.1590/1678-4685-GMB-2015-0170 Snustad P and Simmons MJ (2013). Fundamentos de genética. 6th edn. Guanabara Koogan, Rio de Janeiro. Strapasson RL, Cervi AC, Carvalho JE, Ruiz AL, et al (2012). Bioactivity-guided isolation of cytotoxic sesquiterpene lactones of Gochnatia polymorpha ssp. floccosa. Phytother. Res. 26: 1053-1056. http://dx.doi.org/10.1002/ptr.3693 Zar HJ, Udwadia ZF, et al (2013). Advances in tuberculosis 2011-2012. Thorax 68: 283-287. http://dx.doi.org/10.1136/thoraxjnl-2012-203127
R. J. Oliveira, de David, N., Pesarini, J. R., Nogueira, T. D., Kassuya, C. A. L., Strapasson, R. L. B., Stefanello, M. E. A., Monreal, A. C. D., Matuo, R., Antoniolli-Silva, A. C. M. B., Oliveira, R. J., de David, N., Pesarini, J. R., Nogueira, T. D., Kassuya, C. A. L., Strapasson, R. L. B., Stefanello, M. E. A., Monreal, A. C. D., Matuo, R., Antoniolli-Silva, A. C. M. B., Oliveira, R. J., de David, N., Pesarini, J. R., Nogueira, T. D., Kassuya, C. A. L., Strapasson, R. L. B., Stefanello, M. E. A., Monreal, A. C. D., Matuo, R., and Antoniolli-Silva, A. C. M. B., “Moquiniastrum polymorphum subsp floccosum extract: screening for mutagenic and antimutagenic activity”, vol. 15, no. 4, p. -, 2016.
Conflicts of interest The authors declare no conflicts of interest. ACKNOWLEDGMENTS Research supported by FUNDECT (Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul), CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico). REFERENCES Bohlmann F, Zdero C, Schmeda-Hirschmann G, Jakupovic J, et al (1986). Dimeric guainolides and other constituents from Gochnatia species. Phytochemistry 44: 1175-1178. http://dx.doi.org/10.1016/S0031-9422(00)81575-7 Bueno NR, Castilho RO, Costa RB, Pott A, et al (2005). Medicinal plants used by the Kaiowá and Guarani indigenous populations in the Caarapó reserve, Mato Grosso do Sul, Brazil. Acta Bot. Bras. 19: 39-44. http://dx.doi.org/10.1590/S0102-33062005000100005 Cantero WB, Takahachi NA, Mauro MO, Pesarini JR, et al (2015). Genomic lesions and colorectal carcinogenesis: the effects of protein-calorie restriction and inulin supplementation on deficiency statuses. Genet. Mol. Res. 14: 2422-2435. http://dx.doi.org/10.4238/2015.March.27.27 Catalan CAN, Vega MI, Lopez ME, Cuenca M del R, et al (2003). Coumarins and a kaurane from Gochnatia polymorpha ssp. Polymorpha from Paraguay. Biochem. Syst. Ecol. 31: 417-422. http://dx.doi.org/10.1016/S0305-1978(02)00163-1 Cooper EL, et al (2004). Drug discovery, CAM and natural products. Evid. Based Complement. Alternat. Med. 1: 215-217. http://dx.doi.org/10.1093/ecam/neh032 Cragg GM, Newman DJ, et al (2013). Natural products: a continuing source of novel drug leads. Biochim. Biophys. Acta 1830: 3670-3695. http://dx.doi.org/10.1016/j.bbagen.2013.02.008 David Nd, Mauro MdeO, Gonçalves CA, Pesarini JR, et al (2014). Gochnatia polymorpha ssp. floccosa: bioprospecting of an anti-inflammatory phytotherapy for use during pregnancy. J. Ethnopharmacol. 154: 370-379. http://dx.doi.org/10.1016/j.jep.2014.04.005 Farias ACM, Da Silva JR, Tomassini TCB, et al (1984). Constituents of Mochinea polymorpha. J. Nat. Prod. 47: 363-364. http://dx.doi.org/10.1021/np50032a021 Fedel-Miyasato LES, Formagio ASN, Auharek SA, Kassuya CAL, et al (2014a). Antigenotoxic and antimutagenic effects of Schinus terebinthifolius Raddi in Allium cepa and Swiss mice: a comparative study. Genet. Mol. Res. 13: 3411-3425. http://dx.doi.org/10.4238/2014.April.30.2 Fedel-Miyasato LES, Kassuya CAL, Auharek SA, Formagio ASN, et al (2014b). Evaluation of anti-inflammatory, immunomodulatory, chemopreventive and wound healing potentials from Schinus terebinthifolius methanolic extract. Braz. J. Pharmacog. 24: 565-575. Felicidade I, Lima JD, Pesarini JR, Monreal ACD, et al (2014a). Mutagenic and antimutagenic effects of aqueous extract of rosemary (Rosmarinus officinalis L.) on meristematic cells of Allium cepa. Genet. Mol. Res. 13: 9986-9996. http://dx.doi.org/10.4238/2014.November.28.3 Felicidade I, Lima JD, Pesarini JR, Monreal ACD, et al (2014b). Mutagenic and antimutagenic effects of crude hydroalcoholic extract of rosemary (Rosmarinus officinalis L.) on cultured meristematic cells Allium cepa. VRI Phytomedicine 2: 30-39. Fiskesjö G, et al (1993). The Allium test in wastewater monitoring. Environ. Toxicol. 8: 291-298. Leme DM, Marin-Morales MA, et al (2009). Allium cepa test in environmental monitoring: a review on its application. Mutat. Res. 682: 71-81. http://dx.doi.org/10.1016/j.mrrev.2009.06.002 López ME, Giordano OS, López LA, et al (2002). Sesquiterpene lactone dehydroleucodine selectively induces transient arrest in G2 in Allium cepa root meristematic cells. Protoplasma 219: 82-88. http://dx.doi.org/10.1007/s007090200008 Magosso MF, Carvalho PC, Shneider BU, Pessatto LR, et al (2016). Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide. Genet. Mol. Res. 15. http://dx.doi.org/10.4238/gmr.15027816 Manoharan K, Banerjee MR, et al (1985). beta-Carotene reduces sister chromatid exchanges induced by chemical carcinogens in mouse mammary cells in organ culture. Cell Biol. Int. Rep. 9: 783-789. http://dx.doi.org/10.1016/0309-1651(85)90096-7 Martello MD, David N, Matuo R, Carvalho PC, et al (2016). Campomanesia adamantium extract induces DNA damage, apoptosis, and affects cyclophosphamide metabolism. Genet. Mol. Res. 15. http://dx.doi.org/10.4238/gmr.15027678 Martins GG, Lívero FA, Stolf AM, Kopruszinski CM, et al (2015). Sesquiterpene lactones of Moquiniastrum polymorphum subsp. floccosum have antineoplastic effects in Walker-256 tumor-bearing rats. Chem. Biol. Interact. 228: 46-56. http://dx.doi.org/10.1016/j.cbi.2015.01.018 Mauro MO, Pesarini JR, Marin-Morales MA, Monreal MT, et al (2014). Evaluation of the antimutagenic activity and mode of action of the fructooligosaccharide inulin in the meristematic cells of Allium cepa culture. Genet. Mol. Res. 13: 4808-4819. http://dx.doi.org/10.4238/2014.February.14.14 Moreira AS, Spitzer V, Schapoval EE, Schenkel EP, et al (2000). Antiinflammatory activity of extracts and fractions from the leaves of Gochnatia polymorpha. Phytother. Res. 14: 638-640. http://dx.doi.org/10.1002/1099-1573(200012)14:8<638::AID-PTR681>3.0.CO;2-Q Nantes CI, Pesarini JR, Mauro MO, Monreal ACD, et al (2014). Evaluation of the antimutagenic activity and mode of action of carrageenan fiber in cultured meristematic cells of Allium cepa. Genet. Mol. Res. 13: 9523-9532. http://dx.doi.org/10.4238/2014.November.12.1 Navarro SD, Mauro MO, Pesarini JR, Ogo FM, et al (2015). Resistant starch: a functional food that prevents DNA damage and chemical carcinogenesis. Genet. Mol. Res. 14: 1679-1691. http://dx.doi.org/10.4238/2015.March.6.14 Oliveira RJ, Ribeiro LR, da Silva AF, Matuo R, et al (2006). Evaluation of antimutagenic activity and mechanisms of action of β-glucan from barley, in CHO-k1 and HTC cell lines using the micronucleus test. Toxicol. In Vitro 20: 1225-1233. http://dx.doi.org/10.1016/j.tiv.2006.04.001 Oliveira RJ, Matuo R, da Silva AF, Matiazi HJ, et al (2007). Protective effect of β-glucan extracted from Saccharomyces cerevisiae, against DNA damage and cytotoxicity in wild-type (k1) and repair-deficient (xrs5) CHO cells. Toxicol. In Vitro 21: 41-52. http://dx.doi.org/10.1016/j.tiv.2006.07.018 Oliveira RJ, Fronza LS, Honda RE, Aquino MT, et al (2015). Effects of Avena sativa L. supplementation on ponderal development, reproductive performance and embryo-fetal development of pregnant rats exposed to cyclophosphamide. PECIBES 1: 1-8. Piornedo R dos R, de Souza P, Stefanello MÉ, Strapasson RL, et al (2011). Anti-inflammatory activity of extracts and 11,13-dihydrozaluzanin C from Gochnatia polymorpha ssp. floccosa trunk bark in mice. J. Ethnopharmacol. 133: 1077-1084. http://dx.doi.org/10.1016/j.jep.2010.11.040 Rang HP, Dale MM, Ritter JM, Flower RJ, et al. (2012). Rang & Dale's pharmacology. 7th edn. Churchill Livingstone, Edinburgh. Rank J, Nielsen MH, et al (1997). Allium cepa anaphase-telophase root tip chromosome aberration assay on N-methyl-N-nitrosourea, maleic hydrazide, sodium azide, and ethyl methanesulfonate. Mutat. Res. 390: 121-127. http://dx.doi.org/10.1016/S0165-1218(97)00008-6 Rocha RS, Kassuya CAL, Formagio AS, Mauro M de O, et al (2016). Analysis of the anti-inflammatory and chemopreventive potential and description of the antimutagenic mode of action of the Annona crassiflora methanolic extract. Pharm. Biol. 54: 35-47. http://dx.doi.org/10.3109/13880209.2015.1014567 Roque N (2014). Moquiniastrum. Lista de espécies da flora do Brasil. Jardim Botânico do Rio de Janeiro. Available at [http://floradobrasil.jbrj.gov.br/jabot/floradobrasil/FB130872]. Accessed June 28, 2016. Sacilotto ACB, Vichnewski W, Herz W, et al (1997). Ent-kaurene diterpenes from Gochnatia polymorpha var. polymorpha. Phytochemistry 44: 659-661. http://dx.doi.org/10.1016/S0031-9422(96)00601-2 Schlemper V, Freitas SA, Schlemper SEM, et al (2011). Antispasmodic effects of hydroalcoholic extract from Gochnatia polymorpha ssp. floccosa in the guinea pig ileum. Res. J. Med. Plant 5: 288-294. http://dx.doi.org/10.3923/rjmp.2011.288.294 Schneider BUC, Meza A, Beatriz A, Pesarini JR, et al (2016). Cardanol: toxicogenetic assessment and its effects when combined with cyclophosphamide. Genet. Mol. Biol. 39: 279-289. http://dx.doi.org/10.1590/1678-4685-GMB-2015-0170 Snustad P and Simmons MJ (2013). Fundamentos de genética. 6th edn. Guanabara Koogan, Rio de Janeiro. Strapasson RL, Cervi AC, Carvalho JE, Ruiz AL, et al (2012). Bioactivity-guided isolation of cytotoxic sesquiterpene lactones of Gochnatia polymorpha ssp. floccosa. Phytother. Res. 26: 1053-1056. http://dx.doi.org/10.1002/ptr.3693 Zar HJ, Udwadia ZF, et al (2013). Advances in tuberculosis 2011-2012. Thorax 68: 283-287. http://dx.doi.org/10.1136/thoraxjnl-2012-203127
2015
R. J. Oliveira, Mantovani, M. S., Pesarini, J. R., Mauro, M. O., da Silva, A. F., Souza, T. R., and Ribeiro, L. R., “6-Dimethylaminopurine and cyclohexamide are mutagenic and alter reproductive performance and intrauterine development in vivo”, vol. 14, pp. 834-849, 2015.
W. B. Cantero, Takahachi, N. A., Mauro, M. O., Pesarini, J. R., Rabacow, A. P. M., Antoniolli, A. C. M. B., and Oliveira, R. J., “Genomic lesions and colorectal carcinogenesis: the effects of protein-calorie restriction and inulin supplementation on deficiency statuses”, vol. 14, pp. 2422-2435, 2015.
S. D. Navarro, Mauro, M. O., Pesarini, J. R., Ogo, F. M., and Oliveira, R. J., “Resistant starch: a functional food that prevents DNA damage and chemical carcinogenesis”, vol. 14, pp. 1679-1691, 2015.
2014
J. R. Pesarini, Victorelli, S. G., Vicentini, A. P., Ferreira, L. K., Mauro, M. O., Matuo, R., Oliveira, J. R., Antoniolli, A. C. M. B., Mantovani, M. S., and Oliveira, R. J., “Antigenotoxic and antimutagenic effects of glutamine supplementation on mice treated with cisplatin”, vol. 13, pp. 4820-4830, 2014.
R. J. Oliveira, Pesarini, J. R., Mauro, M. O., Fronza, L. S., Victorelli, S. G., Cantero, W. B., Sena, M. C., and Antoniolli, A. C. M. B., “Effects of phenylalanine on reproductive performance and teratogenesis in mice”, vol. 13, pp. 5606-5616, 2014.
C. I. Nantes, Pesarini, J. R., Mauro, M. O., Monreal, A. C. D., Ramires, A. D., and Oliveira, R. J., “Evaluation of the antimutagenic activity and mode of action of carrageenan fiber in cultured meristematic cells of Allium cepa”, vol. 13, pp. 9523-9532, 2014.
M. O. Mauro, Pesarini, J. R., Marin-Morales, M. A., Monreal, M. T. F. D., Monreal, A. C. D., Mantovani, M. S., and Oliveira, R. J., “Evaluation of the antimutagenic activity and mode of action of the fructooligosaccharide inulin in the meristematic cells of Allium cepa culture”, vol. 13, pp. 4808-4819, 2014.
I. Felicidade, Lima, J. D., Pesarini, J. R., Monreal, A. C. D., Mantovani, M. S., Ribeiro, L. R., and Oliveira, R. J., “Mutagenic and antimutagenic effects of aqueous extract of rosemary (Rosmarinus officinalis L.) on meristematic cells of Allium cepa”, vol. 13, pp. 9986-9996, 2014.
2013
J. R. Pesarini, Zaninetti, P. T., Mauro, M. O., Carreira, C. M., Dichi, J. B., Ribeiro, L. R., Mantovani, M. S., and Oliveira, R. J., “Antimutagenic and anticarcinogenic effects of wheat bran in vivo”, vol. 12, pp. 1646-1659, 2013.
M. O. Mauro, Monreal, M. T. F. D., Silva, M. T. P., Pesarini, J. R., Mantovani, M. S., Ribeiro, L. R., Dichi, J. B., Carreira, C. M., and Oliveira, R. J., “Evaluation of the antimutagenic and anticarcinogenic effects of inulin in vivo”, vol. 12, pp. 2281-2293, 2013.
R. J. Oliveira, Sassaki, E. S., Monreal, A. C. D., Monreal, M. T. F. D., Pesarini, J. R., Mauro, M. O., Matuo, R., Silva, A. F., Zobiole, N. N., Siqueira, J. M., Ribeiro, L. R., and Mantovani, M. S., “Pre-treatment with glutamine reduces genetic damage due to cancer treatment with cisplatin”, vol. 12, pp. 6040-6051, 2013.