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2011
L. P. Felício, Silva, E. M., Ribeiro, V., Miranda, C. T., Vieira, I. L. B. F., Passos, D. C. S., Ferreira, A. K. S., Vale, C. R., Lima, D. C. S., Carvalho, S., and Nunes, W. B., Mutagenic potential and modulatory effects of the medicinal plant Luehea divaricata (Malvaceae) in somatic cells of Drosophila melanogaster: SMART/wing, vol. 10, pp. 16-24, 2011.
Artavanis-Tsakonas S, Matsuno K and Fortini ME (1995). Notch signaling. Science 268: 225-232. http://dx.doi.org/10.1126/science.7716513 PMid:7716513   Balbach A (1993). As Plantas Curam. Editora Missionária, Itaquaquecetuba. PMid:8384724   Calixto JB (2000). Biopirataria - A Diversidade Biológica na Mira da Indústria Farmacêutica. Ciência Hoje, Rio de Janeiro. 36-43.   Campelo PMS (2006). Plantas Medicinais e Seus Extratos: A Necessidade de Estudos Continuados. Estud. Biol. 28: 62.   Carvalho JE (2006). Atividade antiulcerogênica e anticâncer de produtos naturais e de síntese. Multiciência 7: 1-18.   Franchi LP, Guimarães NN, Lehmann M, Andrade HHR, et al. (2008). Ausência de efeito tóxicogênico de Morinda citrifolia (NONI) em células somática de Drosophila melanogaster. Rev. Eletrônica Farm. 5: 46-536.   Frei H and Würgler FE (1988). Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive, negative, or inconclusive result. Mutat. Res. 203: 297-308. http://dx.doi.org/10.1016/0165-1161(88)90019-2   Frei H and Würgler FE (1995). Optimal experimental design and sample size for the statistical evaluation of data from somatic mutation and recombination tests (SMART) in Drosophila. Mutat. Res. 334: 247-258. http://dx.doi.org/10.1016/0165-1161(95)90018-7   Giulietti AM, Harley RM, Queiroz LP, Wanderley MG, et al. (2005). Biodiversidade e conservação das plantas no Brasil. Megadiversidade 1: 52-61. Avaliable at [http://www.agencia.cnptia.embrapa.br/recursos/BIOD_ConservacaoID-eWNPNpKEJw.pdf]. Accessed November 22, 2010.   Graf U and van Schaik N (1992). Improved high bioactivation cross for the wing somatic mutation and recombination test in Drosophila melanogaster. Mutat. Res. 271: 59-67. http://dx.doi.org/10.1016/0165-1161(92)90032-H   Graf U, Wurgler FE, Katz AJ, Frei H, et al. (1984). Somatic mutation and recombination test in Drosophila melanogaster. Environ. Mutagen. 6: 153-188. http://dx.doi.org/10.1002/em.2860060206 PMid:6423380   Graf U, Frei H, Kagi A, Katz AJ, et al. (1989). Thirty compounds tested in the Drosophila wing spot test. Mutat. Res. 222: 359-373. http://dx.doi.org/10.1016/0165-1218(89)90112-2   Gusmán-Rincón J and Graf U (1995). Drosophila melanogaster Somatic Mutation and Recombination Test as a Biomonitor. In: Biomonitors and Biomarkers as Indicators of Environmental Change. Plenum Press, New York, 169-181.   Ioris EM (Org.) (1999). Plantas Medicinais do Cerrado: Perspectivas Comunitárias para a Saúde, o Meio Ambiente e o Desenvolvimento Sustentável. 1º edição. Fundação Integrada Municipal de Ensino Superior, Mineiros.   Lorenzi H (1998). Árvores Brasileiras: Manual de Identificação e Cultivo de Plantas Arbóreas Nativas do Brasil. Plantarum, Nova Odessa.   Mendanha DM, Ferreira HD, Felicio LP, Silva EM, et al. (2010). Modulatory effect of Byrsonima verbascifolia (Malpighiaceae) against damage induced by doxorubicin in somatic cells of Drosophila melanogaster. Genet. Mol. Res. 9: 69-77. http://dx.doi.org/10.4238/vol9-1gmr678 PMid:20092036   Miklos GL and Rubin GM (1996). The role of the genome project in determining gene function: insights from model organisms. Cell 86: 521-529. http://dx.doi.org/10.1016/S0092-8674(00)80126-9   Müller JB, Ceron CS, Kuntz VT and Pozzatti P (2006). Avaliação da Suscetibilidade Antifúngica e Antibacteriana do Extrato Bruto e Frações das Folhas de Luehea divaricata Martius. Anais da 58ª Reunião Anual da SBPC, Florianópolis.   Nunes WB (2004). Efeito Modulador do Extrato Aquoso Padronizado de Ginkgo biloba (EGb 761) Contra Mutações e Recombinações Somáticas Induzidas pela Doxorrubicina em Células Somáticas de Drosophila melanogaster. Doctoral thesis, UFU, Uberlândia.   Nussbaum RL, McInnes RR and Willard HF (2008). Genética Médica. 7ª edição. Elsevier, Rio de Janeiro.   Passos DC, Ferreira HD, Vieira IL, Nunes WB, et al. (2010). Modulatory effect of Palicourea coriacea (Rubiaceae) against damage induced by doxorubicin in somatic cells of Drosophila melanogaster. Genet. Mol. Res. 9: 1153-1162. http://dx.doi.org/10.4238/vol9-2gmr801 PMid:20568060   Robert J and Gianni L (1993). Pharmacokinetics and metabolism of anthracyclines. Cancer Surv. 17: 219-252. PMid:8137342   Saner C, Weibel B, Wurgler FE and Sengstag C (1996). Metabolism of promutagens catalyzed by Drosophila melanogaster CYP6A2 enzyme in Saccharomyces cerevisiae. Environ. Mol. Mutagen. 27: 46-58. http://dx.doi.org/10.1002/(SICI)1098-2280(1996)27:1<46::AID-EM7>3.0.CO;2-C   Silva LD, Nascimento V, Santos SC, Morais JOR, et al. (2003). Análise morfométrica das células de cloro de Poecilia vivipara expostas a frações da folha e da casca do caule de Caryocar brasiliensis. Portal de Periódicos da UEM. Available at [http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/viewFile/2107/1545]. Accessed November 22, 2010.   Siqueira MG (2006). Atividade Antiulcerogênica do Extrato Bruto Hidroalcoólico da Luehea divaricata Martus et Zuccarini. 100 f. Master's thesis, UNICAMP, Campinas.   Takeuchi PL, Antunes LM and Takahashi CS (2007). Evaluation of the clastogenicity and anticlastogenicity of vitamin B6 in human lymphocyte cultures. Toxicol. In Vitro 21: 665-670. http://dx.doi.org/10.1016/j.tiv.2007.01.004 PMid:17320343   Tanaka JCA, Silva CC, Dias Filho BP and Nakamura CV (2005). Constituintes Químicos de Luehea divaricata Mart. (Tiliaceae). Quím. Nova 5: 834-837. http://dx.doi.org/10.1590/S0100-40422005000500020
2010
D. M. Mendanha, Ferreira, H. D., Felício, L. P., Silva, E. M., Pereira, D. G., Nunes, W. B., and Carvalho, S., Modulatory effect of Byrsonima verbascifolia (Malpighiaceae) against damage induced by doxorubicin in somatic cells of Drosophila melanogaster, vol. 9, pp. 69-77, 2010.
Abraham SK (1994). Antigenotoxicity of coffee in the Drosophila assay for somatic mutation and recombination. Mutagenesis 9: 383-386. http://dx.doi.org/10.1093/mutage/9.4.383 PMid:7968582   Agostini T, Cecchi H and Barrera-Arellano D (1995). Chemical characterization of the oil and pulp of marolo (Annona coriaceae). [Caracterização química da polpa e do óleo do marolo (Annona coriaceae)]. Arch. Latinoam. Nutr. 45: 237-241.   Almeida SP (1998). Cerrado: Aproveitamento Alimentar. EMBRAPA-CPAC, Planaltina.   Almeida SP, Proença CE, Sano SM and Ribeiro JF (1998). Cerrado: Espécies Vegetais Úteis. 1st edn. EMBRAPA-CPAC, Planaltina.   Batista JA, Pacheco MFJ and Santos ML (2005). Biologia reprodutiva de três espécies de Byrsonima Rich. ex Kunth (Malpighiaceae) em um cerrado sensu stricto no campus da Universidade Estadual de Goiás, Anápolis, Goiás, Brasil. Rev. Biol. Neotrop. 2: 109-122.   Béliveau R and Gingras D (2007). Os Alimentos Contra o Câncer: A Prevenção e o Tratamento do Câncer pela Alimentação. Vozes, Petrópolis.   Cáceres A, Figueroa L, Taracena AM and Samayoa B (1993). Plants used in Guatemala for the treatment of respiratory diseases. 2: Evaluation of activity of 16 plants against Gram-positive bacteria. J. Ethnopharmacol. 39: 77-82. http://dx.doi.org/10.1016/0378-8741(93)90053-8   Caldeira K (2008). Avaliação Citotóxica, Genotóxica e Moduladora do Anorexígeno Dietilpropiona em Células Somáticas de Drosophila melanogaster: SMART/wing. Master's thesis, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia.   Coelho LS (2007). Acción Moduladora de la Genotoxicidad de la Planta Medicinal Duguetia furfuracea (St. Hil) Benth. & Hook f. em Células Somáticas y Germinativas de Drosophila melanogaster y em Cepas de Salmonella typhimurium. Doctoral thesis, Departamento de Biología Celular y Anatomía, Universidade de Léon, Léon.   Costa HMS, Rabelo CCP, Morais MMC, Coelho LCBB, et al. (2006). Lectins, Tannins and Antimicrobial Activity in Anacardeaceae Barks. Anais da 35ª Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular, Águas de Lindóia.   Costa PM, Ferreira HD, Ferri PH and Guillo LA (2005). Ação moduladora da genotoxicidade da Solanum lycocarpum St. Hil. em micronúcleos induzidos pela ciclofosfamida. Rev. Biol. Neotrop. 2: 43-48.   Costa WF and Nepomuceno JC (2003). Protective effect of the tea of sun mushroom (Agaricus blazei Murill) against genetoxic action of urethane on somatic cells of Drosophila melanogaster. [Efeito protetor do chá de cogumelo do sol (Agaricus blazei Murill) contra a ação genotóxica do uretano em células somáticas de Drosophila melanogaster]. Rev. Cienc. Farm. 24: 153-158.   Frei H and Würgler FE (1988). Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive, negative, or inconclusive result. Mutat. Res. 203: 297-308. http://dx.doi.org/10.1016/0165-1161(88)90019-2   Frei H and Würgler FE (1995). Optimal experimental design and sample size for the statistical evaluation of data from somatic mutation and recombination tests (SMART) in Drosophila. Mutat. Res. 334: 247-258. http://dx.doi.org/10.1016/0165-1161(95)90018-7   Goh LM and Barlow PJ (2002). Antioxidant capacity in Ginkgo biloba. Food Res. Int. 35: 815-820. http://dx.doi.org/10.1016/S0963-9969(02)00084-4   Graf U and van Schaik N (1992). Improved high bioactivation cross for the wing somatic mutation and recombination test in Drosophila melanogaster. Mutat. Res. 271: 59-67. http://dx.doi.org/10.1016/0165-1161(92)90032-H   Graf U, Wurgler FE, Katz AJ, Frei H, et al. (1984). Somatic mutation and recombination test in Drosophila melanogaster. Environ. Mutagen. 6: 153-188. http://dx.doi.org/10.1002/em.2860060206 PMid:6423380   Graf U, Frei H, Kagi A, Katz AJ, et al. (1989). Thirty compounds tested in the Drosophila wing spot test. Mutat. Res. 222: 359-373. http://dx.doi.org/10.1016/0165-1218(89)90112-2   Graf U, Heo OS and Ramirez OO (1992). The genotoxicity of chromium(VI) oxide in the wing spot test of Drosophila melanogaster is over 90% due to mitotic recombination. Mutat. Res. 266: 197-203. http://dx.doi.org/10.1016/0027-5107(92)90187-7   Ito H, Shimura K, Itoh H and Kawade M (1997). Antitumor effects of a new polysaccharide-protein complex (ATOM) prepared from Agaricus blazei (Iwade strain 101) "Himematsutake" and its mechanisms in tumor-bearing mice. Anticancer Res. 17: 277-284. PMid:9066665   Khan MT, Ather A, Thompson KD and Gambari R (2005). Extracts and molecules from medicinal plants against herpes simplex viruses. Antiviral Res. 67: 107-119. http://dx.doi.org/10.1016/j.antiviral.2005.05.002 PMid:16040137   Leite KR, Andrade LS, Sena JS and Vilar JB (2006). Avaliação da atividade mutagênica e genotóxica de Ginkgo biloba L. pelo teste do micronúcleo em camundongos. Rev. Biol. Neotrop. 3: 157-162.   Lopez A, Hudson JB and Towers GH (2001). Antiviral and antimicrobial activities of Colombian medicinal plants. J. Ethnopharmacol. 77: 189-196. http://dx.doi.org/10.1016/S0378-8741(01)00292-6   Lorenzi H and Matos FJA (2002). Plantas Medicinais no Brasil: Nativas e Exóticas Cultivadas. Instituto Plantarum, Nova Odessa.   Mamede MCH (1982). Malpighiaceae. Flora Fanerogâmica da Serra do Cipó, Minas Gerais, Brasil. XXXIII Congresso Nacional de Botânica, Alagoas.   Mendes CLA (2004). Triterpenóides e a sua Actividade Anti-Inflamatória. Faculdade de Ciências e Tecnologias da Universidade Nova de Lisboa, Lisboa.   Miranda-Vilela AL, Resck IS and Grisolia CK (2008). Antigenotoxic activity and antioxidant properties of organic and aqueous extracts of pequi fruit (Caryocar brasiliense Camb.) pulp. Genet. Mol. Biol. 31: 956-963. http://dx.doi.org/10.1590/S1415-47572008000500025   Nunes WB (2004). Efeito Modulador do Extrato Padronizado de Ginkgo biloba (EGb 761) Contra Mutação e Recombinação Somáticas Induzidas pela Doxorrubicina em Células Somáticas de Drosophila melanogaster. Doctoral thesis, Universidade Federal de Uberlândia, Uberlândia.   Panizza S (1998). Plantas que Curam: Cheiro de Mato. 3rd edn. IBRASA, São Paulo.   Passos DCS (2008). Efeito Modulador do Extrato Aquoso de Palicourea coriacea (Cham.) K. Chum. Contra Mutação e Recombinação Somática Induzida pela Doxorrubicina em Células Somáticas de Drosophila melanogaster. Master's thesis, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia.   Pereira DG, Antunes LMG, Graf U and Spanó MA (2008). Protection by Panax ginseng C.A. Meyer against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster. Genet. Mol. Biol. 31: 947-955. http://dx.doi.org/10.1590/S1415-47572008000500024   Pimenta VM and Nepomuceno JC (2005). Genotoxicity testing of Plantago major extracts in somatic cells of Drosophila melanogaster. Environ. Mol. Mutagen. 45: 56-61. http://dx.doi.org/10.1002/em.20079 PMid:15612001   Saner C, Weibel B, Wurgler FE and Sengstag C (1996). Metabolism of promutagens catalyzed by Drosophila melanogaster CYP6A2 enzyme in Saccharomyces cerevisiae. Environ. Mol. Mutagen. 27: 46-58. http://dx.doi.org/10.1002/(SICI)1098-2280(1996)27:1<46::AID-EM7>3.0.CO;2-C   Sannomiya M, Rodrigues CM, Coelho RG, Dos Santos LC, et al. (2004). Application of preparative high-speed counter-current chromatography for the separation of flavonoids from the leaves of Byrsonima crassa Niedenzu (IK). J. Chromatogr. A 1035: 47-51. http://dx.doi.org/10.1016/j.chroma.2004.02.050 PMid:15117073   Sasaki YF, Imanishi H, Ohta T and Watanabe M (1988). Suppressing effect of tannic acid on UV and chemically induced chromosome aberrations in cultured mammalian cells (biological chemistry). Agric. Biol. Chem. 52: 2423-2428. http://dx.doi.org/10.1271/bbb1961.52.2423   Silva CJ, Ferreira HD, Ferri PH, Nunes WB, et al. (2006). Ausência de atividade mutagênica de Guazuma ulmifolia Lamb. (mutamba) em células somáticas de Drosophila melanogaster. Rev. Biol. Neotrop. 3: 163-168.   Silva I, Franco SL, Molinari SL and Conegero CI (1995). Noções Sobre o Organismo Humano e Utilização de Plantas Medicinais. 4th edn. Assoeste, Cascavel.   Simões CMO, Schenkel EP, Gosmann G and Mello JCP (2000). Farmacognosia: da Planta ao Medicamento. 2nd edn. Universidade Federal de Santa Catarina, Florianópolis. PMCid:2620449   Tridente RD (2002). O Uso de Plantas Medicinais na Cidade de Porangatu, Estado de Goiás. Universidade Federal de Goiás, Goiânia.   Vilar JB (2002). Avaliação da Atividade Mutagênica e Antimutagênica de Annona crassiflora Mart. (araticum) pelo Teste de Ames. Graduation paper, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia.
D. C. S. Passos, Ferreira, H. D., Vieira, I. L. F. B., Nunes, W. B., Felício, L. P., Silva, E. M., Vale, C. R., Duarte, S. R., Silva, E. S., and Carvalho, S., Modulatory effect of Palicourea coriacea (Rubiaceae) against damage induced by doxorubicin in somatic cells of Drosophila melanogaster, vol. 9, pp. 1153-1162, 2010.
Abraham SK (1994). Antigenotoxicity of coffee in the Drosophila assay for somatic mutation and recombination. Mutagenesis 9: 383-386. http://dx.doi.org/10.1093/mutage/9.4.383 PMid:7968582   Adjibade Y, Hue B, Pelhate M and Anton R (1991). Action of calycanthine on nervous transmission in cockroach central nervous system. Planta Med. 57: 99-101. http://dx.doi.org/10.1055/s-2006-960040 PMid:1653964   Aparecida Resende F, de Andrade Barcala CA, da Silva Faria MC, Kato FH, et al. (2006). Antimutagenicity of ursolic acid and oleanolic acid against doxorubicin-induced clastogenesis in BALB/c mice. Life Sci. 79: 1268-1273. http://dx.doi.org/10.1016/j.lfs.2006.03.038 PMid:16647723   Baumgartner A, Schmid TE, Cemeli E and Anderson D (2004). Parallel evaluation of doxorubicin-induced genetic damage in human lymphocytes and sperm using the comet assay and spectral karyotyping. Mutagenesis 19: 313-318. http://dx.doi.org/10.1093/mutage/geh032 PMid:15215331   Costa WF and Nepomuceno JC (2006). Protective effects of a mixture of antioxidant vitamins and minerals on the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster. Environ. Mol. Mutagen. 47: 18-24. http://dx.doi.org/10.1002/em.20160 PMid:16010670   da Silva VC, de Carvalho MG and Alves AN (2008). Chemical constituents from leaves of Palicourea coriacea (Rubiaceae). J. Nat. Med. 62: 356-357. http://dx.doi.org/10.1007/s11418-008-0227-2 PMid:18404310   Dhawan A, Anderson D, de Pascual-Teresa S, Santos-Buelga C, et al. (2002). Evaluation of the antigenotoxic potential of monomeric and dimeric flavanols, and black tea polyphenols against heterocyclic amine-induced DNA damage in human lymphocytes using the Comet assay. Mutat. Res. 515: 39-56. http://dx.doi.org/10.1016/S1383-5718(01)00347-3   do Nascimento CA, Gomes MS, Lião LM, de Oliveira CMA, et al. (2006). Alkaloids from Palicourea coriacea (Cham.) K. Schum. Z. Naturforsch. 61b: 1443-1446.   do Nascimento CA, Liao LM, Kato L, da Silva CC, et al. (2008). A tetrahydro b-carboline trisaccharide from Palicourea coriacea (Cham.) K. Schum. Carbohydr. Res. 343: 1104-1107. http://dx.doi.org/10.1016/j.carres.2008.01.032 PMid:18329636   Dorai T and Aggarwal BB (2004). Role of chemopreventive agents in cancer therapy. Cancer Lett. 215: 129-140. http://dx.doi.org/10.1016/j.canlet.2004.07.013 PMid:15488631   Ferreira DT, Alvares PSM, Houghton PJ and Braz-Filho R (2000). Chemical constituents from roots of Pyrostegia venusta and considerations about its medicinal importance. Quím. Nova 23: 42-46. http://dx.doi.org/10.1590/S0100-40422000000100010   Fragiorge EJ, Spanó MA and Antunes LMG (2007). Modulatory effects of the antioxidant ascorbic acid on the direct genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster. Genet. Mol. Biol. 30: 449-455. http://dx.doi.org/10.1590/S1415-47572007000300025   Frei H and Würgler FE (1988). Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive, negative, or inconclusive result. Mutat. Res. 203: 297-308. http://dx.doi.org/10.1016/0165-1161(88)90019-2   Frei H and Würgler FE (1995). Optimal experimental design and sample size for the statistical evaluation of data from somatic mutation and recombination tests (SMART) in Drosophila. Mutat. Res. 334: 247-258. http://dx.doi.org/10.1016/0165-1161(95)90018-7   Graf U and van Schaik N (1992). Improved high bioactivation cross for the wing somatic mutation and recombination test in Drosophila melanogaster. Mutat. Res. 271: 59-67. http://dx.doi.org/10.1016/0165-1161(92)90032-H   Graf U, Würgler FE, Katz AJ, Frei H, et al. (1984). Somatic mutation and recombination test in Drosophila melanogaster. Environ. Mutagen. 6: 153-188. http://dx.doi.org/10.1002/em.2860060206 PMid:6423380   Graf U, Frei H, Kägi A, Katz AJ, et al. (1989). Thirty compounds tested in the Drosophila wing spot test. Mutat. Res. 222: 359-373. http://dx.doi.org/10.1016/0165-1218(89)90112-2   Graf U, Abraham SK, Guzmán-Rincón J and Würgler FE (1998). Antigenotoxicity studies in Drosophila melanogaster. Mutat. Res. 402: 203-209. http://dx.doi.org/10.1016/S0027-5107(97)00298-4   Kada T, Inoue T and Namiki M (1982). Environmental Desmutagens and Antimutagen. In: Environmental Mutagenesis, Carcinogenesis, and Plant Biology (Klekowski EJ, ed.). Praeger Publishers, New York, 133-152.   Keizer HG, Pinedo HM, Schuurhuis GJ and Joenje H (1990). Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity. Pharmacol. Ther. 47: 219-231. http://dx.doi.org/10.1016/0163-7258(90)90088-J   Lehmann M, Franco A, de Souza Prudente Vilar K, Lukza RM, et al. (2003). Doxorubicin and two of its analogues are preferential inducers of homologous recombination compared with mutational events in somatic cells of Drosophila melanogaster. Mutat. Res. 539: 167-175. http://dx.doi.org/10.1016/S1383-5718(03)00162-1   Lima MRF, Luna JS, Santos AF, Andradea MCC, et al. (2006). Anti-bacterial activity of some Brazilian medicinal plants. J. Ethnopharmacol. 105: 137-147. http://dx.doi.org/10.1016/j.jep.2005.10.026 PMid:16356672   Liu J (2005). Oleanolic acid and ursolic acid: research perspectives. J. Ethnopharmacol. 100: 92-94. http://dx.doi.org/10.1016/j.jep.2005.05.024 PMid:15994040   Maurich T, Pistelli L and Turchi G (2004). Anti-clastogenic activity of two structurally related pterocarpans purified from Bituminaria bituminosa in cultured human lymphocytes. Mutat. Res. 561: 75-81. http://dx.doi.org/10.1016/j.mrgentox.2004.03.006 PMid:15238232   Minotti G, Menna P, Salvatorelli E, Cairo G, et al. (2004). Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol. Rev. 56: 185-229. http://dx.doi.org/10.1124/pr.56.2.6 PMid:15169927   Naidu MU, Kumar KV, Mohan IK, Sundaram C, et al. (2002). Protective effect of Gingko biloba extract against doxorubicin-induced cardiotoxicity in mice. Indian J. Exp. Biol. 40: 894-900. PMid:12597018   Nunes GP, Silva MF, Resende UM and Siqueira JM (2003). Medicinal plants from herb sellers operating in downtown Campo Grande, Mato Grosso do Sul, Brazil. Rev. Bras. Farmacogn. 13: 83-92. http://dx.doi.org/10.1590/S0102-695X2003000200004   Ovesná Z, Kozics K and Slamenová D (2006). Protective effects of ursolic acid and oleanolic acid in leukemic cells. Mutat. Res. 600: 131-137. http://dx.doi.org/10.1016/j.mrfmmm.2006.03.008 PMid:16831451   Pellegrina CD, Padovani G, Mainente F, Zoccatelli G, et al. (2005). Anti-tumour potential of a gallic acid-containing phenolic fraction from Oenothera biennis. Cancer Lett. 226: 17-25. http://dx.doi.org/10.1016/j.canlet.2004.11.033 PMid:16004929   Pereira DG, Antunes LGM, Graf U and Spanó MA (2008). Protection by Panax ginseng C.A. Meyer against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster. Genet. Mol. Biol. 31: 947-955. http://dx.doi.org/10.1590/S1415-47572008000500024   Robert J and Gianni L (1993). Pharmacokinetics and metabolism of anthracyclines. Cancer Surv. 17: 219-252. PMid:8137342   Romero-Jiménez M, Campos-Sánchez J, Analla M, Mu-oz-Serrano A, et al. (2005). Genotoxicity and anti-genotoxicity of some traditional medicinal herbs. Mutat. Res. 585: 147-155. http://dx.doi.org/10.1016/j.mrgentox.2005.05.004 PMid:16005256   Roncada T, Vicentini VE and Mantovani MS (2004). Possible modulating actions of plant extracts on the chromosome breaking activity of MMC and Ara-C in human lymphocytes in vitro. Toxicol. In Vitro 18: 617-622. http://dx.doi.org/10.1016/j.tiv.2004.02.007 PMid:15251179   Siddique YH, Ara G, Beg T, Faisal M, et al. (2008). Antigenotoxic role of Centella asiatica L. extract against cyproterone acetate induced genotoxic damage in cultured human lymphocytes. Toxicol. In Vitro 22: 10-17. http://dx.doi.org/10.1016/j.tiv.2007.07.001 PMid:17719740   Tanaka K, Hayatsu T, Negishi T and Hayatsu H (1998). Inhibition of N-nitrosation of secondary amines in vitro by tea extracts and catechins. Mutat. Res. 412: 91-98. http://dx.doi.org/10.1016/S1383-5718(97)00178-2