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“BDNF and DARPP-32 genes are not risk factors for schizophrenia in the Malay population”, vol. 11, pp. 725-730, 2012.
, Albert KA, Hemmings HC Jr, Adamo AI, Potkin SG, et al. (2002). Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Arch. Gen. Psychiatry 59: 705-712.
http://dx.doi.org/10.1001/archpsyc.59.8.705
PMid:12150646
Angelucci F, Brene S and Mathe AA (2005). BDNF in schizophrenia, depression and corresponding animal models. Mol. Psychiatry 10: 345-352.
http://dx.doi.org/10.1038/sj.mp.4001637
PMid:15655562
Chen ZY, Jing D, Bath KG, Ieraci A, et al. (2006). Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314: 140-143.
http://dx.doi.org/10.1126/science.1129663
PMid:17023662 PMCid:1880880
Egan MF, Weinberger DR and Lu B (2003). Schizophrenia, III: brain-derived neurotropic factor and genetic risk. Am. J. Psychiatry 160: 1242.
http://dx.doi.org/10.1176/appi.ajp.160.7.1242
PMid:12832235
Fienberg AA, Hiroi N, Mermelstein PG, Song W, et al. (1998). DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Science 281: 838-842.
http://dx.doi.org/10.1126/science.281.5378.838
PMid:9694658
Gratacòs M, González JR, Mercader JM, de Cid R, et al. (2007). Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia. Biol. Psychiatry 61: 911-922.
http://dx.doi.org/10.1016/j.biopsych.2006.08.025
PMid:17217930
Hong CJ, Yu YW, Lin CH and Tsai SJ (2003). An association study of a brain-derived neurotrophic factor Val66Met polymorphism and clozapine response of schizophrenic patients. Neurosci. Lett. 349: 206-208.
http://dx.doi.org/10.1016/S0304-3940(03)00828-0
Jonsson EG, Edman-Ahlbom B, Sillen A, Gunnar A, et al. (2006). Brain-derived neurotrophic factor gene (BDNF) variants and schizophrenia: an association study. Prog. Neuropsychopharmacol. Biol. Psychiatry 30: 924-933.
http://dx.doi.org/10.1016/j.pnpbp.2006.02.008
PMid:16581172
Kanazawa T, Glatt SJ, Kia-Keating B, Yoneda H, et al. (2007). Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder. Psychiatry Genet. 17: 165-170.
http://dx.doi.org/10.1097/YPG.0b013e32801da2e2
PMid:17417060
Li CH, Liao HM, Hung TW and Chen CH (2006). Mutation analysis of DARPP-32 as a candidate gene for schizophrenia. Schizophr. Res. 87: 1-5.
http://dx.doi.org/10.1016/j.schres.2006.04.003
PMid:16750903
Meyer-Lindenberg A, Straub RE, Lipska BK, Verchinski BA, et al. (2007). Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. J. Clin. Invest. 117: 672-682.
http://dx.doi.org/10.1172/JCI30413
PMid:17290303 PMCid:1784004
Muglia P, Vicente AM, Verga M, King N, et al. (2003). Association between the BDNF gene and schizophrenia. Mol. Psychiatry 8: 146-147.
http://dx.doi.org/10.1038/sj.mp.4001221
PMid:12610646
Murray RM, Sham P, van Os J, Zanelli J, et al. (2004). A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder. Schizophr. Res. 71: 405-416.
http://dx.doi.org/10.1016/j.schres.2004.03.002
PMid:15474912
Nanko S, Kunugi H, Hirasawa H, Kato N, et al. (2003). Brain-derived neurotrophic factor gene and schizophrenia: polymorphism screening and association analysis. Schizophr. Res. 62: 281-283.
http://dx.doi.org/10.1016/S0920-9964(02)00349-3
Neves-Pereira M, Cheung JK, Pasdar A, Zhang F, et al. (2005). BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol. Psychiatry 10: 208-212.
http://dx.doi.org/10.1038/sj.mp.4001575
PMid:15630410
Nishi A, Watanabe Y, Higashi H, Tanaka M, et al. (2005). Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. Proc. Natl. Acad. Sci. U. S. A. 102: 1199-1204.
http://dx.doi.org/10.1073/pnas.0409138102
PMid:15657149 PMCid:545831
Qian L, Zhao J, Shi Y, Zhao X, et al. (2007). Brain-derived neurotrophic factor and risk of schizophrenia: an association study and meta-analysis. Biochem. Biophys. Res. Commun. 353: 738-743.
http://dx.doi.org/10.1016/j.bbrc.2006.12.121
PMid:17196936
Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, et al. (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 59 (Suppl 20): 22-33.
Skibinska M, Hauser J, Czerski PM, Leszczynska-Rodziewicz A, et al. (2004). Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. World J. Biol. Psychiatry 5: 215-220.
http://dx.doi.org/10.1080/15622970410029936
PMid:15543516
Squassina A, Piccardi P, Del Zompo M, Rossi A, et al. (2010). NRG1 and BDNF genes in schizophrenia: an association study in an Italian case-control sample. Psychiatry Res. 176: 82-84.
http://dx.doi.org/10.1016/j.psychres.2009.03.017
PMid:20061032
Svenningsson P, Tzavara ET, Liu F, Fienberg AA, et al. (2002a). DARPP-32 mediates serotonergic neurotransmission in the forebrain. Proc. Natl. Acad. Sci. U. S. A. 99: 3188-3193.
http://dx.doi.org/10.1073/pnas.052712699
PMid:11880652 PMCid:122494
Svenningsson P, Tzavara ET, Witkin JM, Fienberg AA, et al. (2002b). Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac). Proc. Natl. Acad. Sci. U. S. A. 99: 3182-3187.
http://dx.doi.org/10.1073/pnas.052712799
PMid:11880651 PMCid:122493
Takahashi T, Suzuki M, Tsunoda M, Kawamura Y, et al. (2007). Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons. Neurosci. Lett. 435: 34-39.
http://dx.doi.org/10.1016/j.neulet.2008.02.004
PMid:18325670
Tee SF, Chow TJ, Tang PY and Loh HC (2010). Linkage of schizophrenia with TPH2 and 5-HTR2A gene polymorphisms in the Malay population. Genet. Mol. Res. 9: 1274-1278.
http://dx.doi.org/10.4238/vol9-3gmr789
PMid:20623453
Tee SF, Tang PY and Loh HC (2011). No evidence for association between DRD3 and COMT with schizophrenia in a Malay population. Genet. Mol. Res. 10: 1850-1855.
http://dx.doi.org/10.4238/vol10-3gmr1237
PMid:21948748
Tee SF, Tang PY and Loh HC (2012). COMT haplotype analyses in Malaysian with schizophrenia. Psychiatry Res. 195: 83-84.
http://dx.doi.org/10.1016/j.psychres.2011.07.039
PMid:21872942
Xu MQ, St Clair D, Ott J, Feng GY, et al. (2007). Brain-derived neurotrophic factor gene C-270T and Val66Met functional polymorphisms and risk of schizophrenia: a moderate-scale population-based study and meta-analysis. Schizophr. Res. 91: 6-13.
http://dx.doi.org/10.1016/j.schres.2006.12.008
PMid:17289348
“No evidence for association between DRD3 and COMT with schizophrenia in a Malay population”, vol. 10, pp. 1850-1855, 2011.
, Chang HA, Lu RB, Lin WW, Chang CC, et al. (2007). Lack of association between dopamine D3 receptor Ser9Gly polymorphism and schizophrenia in Han Chinese population. Acta Neuropsychiatr. 19: 344-350.
http://dx.doi.org/10.1111/j.1601-5215.2007.00214.x
Chen J, Lipska BK, Halim N, Ma QD, et al. (2004). Functional analysis of genetic variation in catechol-o-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am. J. Hum. Genet. 75: 807-821.
http://dx.doi.org/10.1086/425589
PMid:15457404
Crocq MA, Mant R, Asherson P, Williams J, et al. (1992). Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. J. Med. Genet. 29: 858-860.
http://dx.doi.org/10.1136/jmg.29.12.858
PMid:1362221 PMCid:1016201
De Luca V, Tharmalingam S, Müller DJ, Wong G, et al. (2006). Gene-gene interaction between MAOA and COMT in suicidal behavior: analysis in schizophrenia. Brain Res. 1097: 26-30.
http://dx.doi.org/10.1016/j.brainres.2006.04.053
PMid:16725119
Durany N, Thome J, Palomo A, Foley P, et al. (1996). Homozygosity at the dopamine D3 receptor gene in schizophrenic patients. Neurosci. Lett. 220: 151-154.
http://dx.doi.org/10.1016/S0304-3940(96)13251-1
Ebstein RP, Macciardi F, Heresco-Levi U, Serretti A, et al. (1997). Evidence for an association between the dopamine D3 receptor gene DRD3 and schizophrenia. Hum. Hered. 47: 6-16.
http://dx.doi.org/10.1159/000154382
PMid:9017973
Fathalli F, Rouleau GA, Xiong L, Tabbane K, et al. (2008). No association between the DRD3 Ser9Gly polymorphism and schizophrenia. Schizophr. Res. 98: 98-104.
http://dx.doi.org/10.1016/j.schres.2007.07.002
PMid:17698325
Hoogendoorn ML, Bakker SC, Schnack HG, Selten JP, et al. (2005). No association between 12 dopaminergic genes and schizophrenia in a large Dutch sample. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 134B: 6-9.
http://dx.doi.org/10.1002/ajmg.b.30147
PMid:15635698
Ioannidis JP, Ntzani EE, Trikalinos TA and Contopoulos-Ioannidis DG (2001). Replication validity of genetic association studies. Nat. Genet. 29: 306-309.
http://dx.doi.org/10.1038/ng749
PMid:11600885
Jonsson EG, Flyckt L, Burgert E, Crocq MA, et al. (2003). Dopamine D3 receptor gene Ser9Gly variant and schizophrenia: association study and meta-analysis. Psychiatr. Genet. 13: 1-12.
http://dx.doi.org/10.1097/00041444-200303000-00001
Jonsson EG, Kaiser R, Brockmoller J, Nimgaonkar VL, et al. (2004). Meta-analysis of the dopamine D3 receptor gene (DRD3) Ser9Gly variant and schizophrenia. Psychiatr. Genet. 14: 9-12.
http://dx.doi.org/10.1097/00041444-200403000-00002
Kunugi H, Vallada HP, Hoda F, Kirov G, et al. (1997). No evidence for an association of affective disorders with high- or low-activity allele of catechol-o-methyltransferase gene. Biol. Psychiatry. 42: 282-285.
http://dx.doi.org/10.1016/S0006-3223(96)00366-6
Lannfelt L, Sokoloff P, Martres MP, Pilon C, et al. (1992). Amino acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders. Psychiatr. Genet. 2: 249-252.
http://dx.doi.org/10.1097/00041444-199210000-00003
Le Coniat M, Sokoloff P, Hillion J, Martres MP, et al. (1991). Chromosomal localization of the human D3 dopamine receptor gene. Hum. Genet. 87: 618-620.
PMid:1916765
Nagaraj S, Lee KH, Tey NP and Ng CW (2008). Counting and Integration: The Experience of Malaysia, Working Paper Series, No 2008-3. Faculty of Economics and Administration, University of Malaya, Malaya.
National Mental Health Registry Report (2003-2005). Department of Psychiatric and Mental Health, Hospital Kuala Lumpur, National Mental Health Registry, Kuala Lumpur.
Pal P, Mihanovic M, Molnar S, Xi H, et al. (2009). Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population. Croat. Med. J. 50: 361-369.
http://dx.doi.org/10.3325/cmj.2009.50.361
PMid:19673036 PMCid:2728391
Scharfetter J, Chaudhry HR, Hornik K, Fuchs K, et al. (1999). Dopamine D3 receptor gene polymorphism and response to clozapine in schizophrenic Pakistani patients. Eur. Neuropsychopharmacol. 10: 17-20.
http://dx.doi.org/10.1016/S0924-977X(99)00044-9
Schulze TG and McMahon FJ (2002). Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines. Am. J. Med. Genet. 114: 1-11.
http://dx.doi.org/10.1002/ajmg.10042
PMid:11840498
Schwab SG and Wildenauer DB (2008). Research on causes for schizophrenia: are we close? Schizophr. Res. 102: 29-30.
http://dx.doi.org/10.1016/j.schres.2008.04.005
Shifman S, Bronstein M, Sternfeld M, Pisante A, et al. (2004). COMT: a common susceptibility gene in bipolar disorder and schizophrenia. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 128B: 61-64.
http://dx.doi.org/10.1002/ajmg.b.30032
PMid:15211633
Spurlock G, Williams J, McGuffin P, Aschauer HN, et al. (1998). European multicentre association study of schizophrenia: a study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms. Am. J. Med. Genet. 81: 24-28.
http://dx.doi.org/10.1002/(SICI)1096-8628(19980207)81:1<24::AID-AJMG5>3.0.CO;2-N
Staddon S, Arranz MJ, Mancama D, Perez-Nievas F, et al. (2005). Association between dopamine D3 receptor gene polymorphisms and schizophrenia in an isolate population. Schizophr. Res. 73: 49-54.
http://dx.doi.org/10.1016/j.schres.2004.06.011
PMid:15567076
Suzuki M, Hurd YL, Sokoloff P, Schwartz JC, et al. (1998). D3 dopamine receptor mRNA is widely expressed in the human brain. Brain Res. 779: 58-74.
http://dx.doi.org/10.1016/S0006-8993(97)01078-0
Talkowski ME, Mansour H, Chowdari KV, Wood J, et al. (2006). Novel, replicated associations between dopamine D3 receptor gene polymorphisms and schizophrenia in two independent samples. Biol. Psychiatry 60: 570-577.
http://dx.doi.org/10.1016/j.biopsych.2006.04.012
PMid:16893532
Tenhunen J, Salminen M, Lundstrom K, Kiviluoto T, et al. (1994). Genomic organization of the human catechol-o-methyltransferase gene and its expression from two distinct promoters. Eur. J. Biochem. 223: 1049-1059.
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PMid:8055944
Utsunomiya K, Shinkai T, De Luca V, Hwang R, et al. (2008). Genetic association between the dopamine D3 gene polymorphism (Ser9Gly) and schizophrenia in Japanese populations: evidence from a case-control study and meta-analysis. Neurosci. Lett. 444: 161-165.
http://dx.doi.org/10.1016/j.neulet.2008.08.005
PMid:18703116
Zhang K, Gao J, An C, Gao X, et al. (2007). An association study between cathechol-o-methyltransferase gene and mental retardation in the Chinese Han population. Neurosci. Lett. 419: 83-87.
http://dx.doi.org/10.1016/j.neulet.2007.03.050
PMid:17442488
“Linkage of schizophrenia with TPH2 and 5-HTR2A gene polymorphisms in the Malay population”, vol. 9, pp. 1274-1278, 2010.
, Abdolmaleky HM, Faraone SV, Glatt SJ and Tsuang MT (2004). Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. Schizophr. Res. 67: 53-62.
http://dx.doi.org/10.1016/S0920-9964(03)00183-X
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Anttila S, Viikki M, Huuhka K, Huuhka M, et al. (2009). TPH2 polymorphisms may modify clinical picture in treatment-resistant depression. Neurosci. Lett. 464: 43-46.
http://dx.doi.org/10.1016/j.neulet.2009.08.018
PMid:19679166
Arango V, Underwood MD and Mann JJ (1997). Postmortem findings in suicide victims. Implications for in vivo imaging studies. Ann. N. Y. Acad. Sci. 836: 269-287.
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Li K, Zhang YQ, Yu P and Cheng YR (2006). Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide. Brain Res. 1122: 24-26.
http://dx.doi.org/10.1016/j.brainres.2006.09.007
PMid:17011525
Mann JJ, Currier D, Murphy L, Huang YY, et al. (2008). No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover. J. Affect. Disord. 106: 117-121.
http://dx.doi.org/10.1016/j.jad.2007.05.031
PMid:17604842 PMCid:2756663
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http://dx.doi.org/10.1016/j.neulet.2006.09.060
PMid:17123728
Nagaraj S, Lee KH, Tey NP, Ng CW, et al. (2008). Counting and Integration: The Experience of Malaysia, Working Paper Series, No. 2008-3. Faculty of Economics and Administration, University of Malaya, Kuala Lumpur.
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http://dx.doi.org/10.1001/archpsyc.55.7.593
PMid:9672049
Pe-as-Lledó EM, Dorado P, Caceres MC, de la Rubia A, et al. (2007). Association between T102C and A-1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs. Clin. Chem. Lab. Med. 45: 835-838.
PMid:17617023
Prasad KM, Talkowski ME, Chowdari KV, McClain L, et al. (2009). Candidate genes and their interactions with other genetic/environmental risk factors in the etiology of schizophrenia. Brain Res. Bull. (in press).
PMid:19729054
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http://dx.doi.org/10.1016/j.pnpbp.2007.01.012
PMid:17291660
Schulze TG and McMahon FJ (2002). Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines. Am. J. Med. Genet. 114: 1-11.
http://dx.doi.org/10.1002/ajmg.10042
PMid:11840498
Schwab SG and Wildenauer DB (2008). Research on causes for schizophrenia: are we close? Schizophr. Res. 102: 29-30.
http://dx.doi.org/10.1016/j.schres.2008.04.005
PMid:18705138
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Zill P, Buttner A, Eisenmenger W, Moller HJ, et al. (2004a). Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol. Psychiatry 56: 581-586.
http://dx.doi.org/10.1016/j.biopsych.2004.07.015
PMid:15476687
Zill P, Baghai TC, Zwanzger P, Schule C, et al. (2004b). SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol. Psychiatry 9: 1030-1036.
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