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J. Hailati, Yang, Y. C., Zhang, L., He, P. Y., Baikeyi, M., Muhuyati, W., and Liu, Z. Q., Association between -44G/A and +71A/G polymorphisms in the connexin 40 gene and atrial fibrillation in Uyghur and Han populations in Xinjiang, China, vol. 15, no. 4, p. -, 2016.
Conflicts of interestThe authors declare no conflict of interest.ACKNOWLEDGMENTSThe First Affiliated Hospital of Xinjiang Medical University provided the experimental platform. Research supported by the Natural Science Foundation of China (NSFC; #81260036).REFERENCESChaldoupi SM, Loh P, Hauer RN, de Bakker JM, et al (2009). The role of connexin40 in atrial fibrillation. Cardiovasc. Res. 84: 15-23. Dbouk HA, Mroue RM, El-Sabban ME, Talhouk RS, et al (2009). Connexins: a myriad of functions extending beyond assembly of gap junction channels. Cell Commun. Signal. 7: 4. Dupont E, Ko Y, Rothery S, Coppen SR, et al (2001). The gap-junctional protein connexin40 is elevated in patients susceptible to postoperative atrial fibrillation. Circulation 103: 842-849. European Society of Hypertension-European Society of Cardiology Guidelines Committeeet al (2003). 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J. Hypertens. 21: 1011-1053. Firouzi M, Ramanna H, Kok B, Jongsma HJ, et al (2004). Association of human connexin40 gene polymorphisms with atrial vulnerability as a risk factor for idiopathic atrial fibrillation. Circ. Res. 95: e29-e33. Fuster V, Rydén LE, Cannom DS, Crijns HJ, Task Force on Practice Guidelines, American College of Cardiology/American Heart AssociationCommittee for Practice Guidelines, European Society of CardiologyEuropean Heart Rhythm AssociationHeart Rhythm Societyet al (2006). ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation-executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation). Eur. Heart J. 27: 1979-2030. Groenewegen WA, Firouzi M, Bezzina CR, Vliex S, et al (2003). A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstill. Circ. Res. 92: 14-22. Hagendorff A, Schumacher B, Kirchhoff S, Lüderitz B, et al (1999). Conduction disturbances and increased atrial vulnerability in Connexin40-deficient mice analyzed by transesophageal stimulation. Circulation 99: 1508-1515. Hauer RN, Groenewegen WA, Firouzi M, Ramanna H, et al (2006). Cx40 polymorphism in human atrial fibrillation. Adv. Cardiol. 42: 284-291. Hu D, Sun Y, et al (2008). Epidemiology, risk factors for stroke, and management of atrial fibrillation in China. J. Am. Coll. Cardiol. 52: 865-868. January CT, Wann LS, Alpert JS, Calkins H, ACC/AHA Task Force Memberset al (2014). 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation 130: 2071-2104. Juang JM, Chern YR, Tsai CT, Chiang FT, et al (2007). The association of human connexin 40 genetic polymorphisms with atrial fibrillation. Int. J. Cardiol. 116: 107-112. Mu HYT, Ma YT, Lu WH, Zhang YM, et al (2007a). An analysis on racial and clinical characters for 1436 patients with atrial fibrillation in hospitalization. Chin. J. Card. Pacing Electrophysiol. 21: 125-127. Mu HYT, Lu WH, Ma YT, Zhang YM, et al (2007b). Clinical analysis for nonvalvular atrial fibrillation with thromboembolism patients. Chin. J. Card. 35: 671. Mu HYT, Lu WH, Ma YT, Zhang YM, et al (2008). The comparison of clinical features in atrial fibrillation between the Uyghurs and Hans patients. Chin. J. Card. Pacing Electrophysiol. 22: 216-218. Polontchouk L, Haefliger JA, Ebelt B, Schaefer T, et al (2001). Effects of chronic atrial fibrillation on gap junction distribution in human and rat atria. J. Am. Coll. Cardiol. 38: 883-891. Severs NJ, et al (1990). The cardiac gap junction and intercalated disc. Int. J. Cardiol. 26: 137-173. Sun Y, Hills MD, Ye WG, Tong X, et al (2014). Atrial fibrillation-linked germline GJA5/connexin40 mutants showed an increased hemichannel function. PLoS One 9: e95125. van der Velden HM, Ausma J, Rook MB, Hellemons AJ, et al (2000). Gap junctional remodeling in relation to stabilization of atrial fibrillation in the goat. Cardiovasc. Res. 46: 476-486. Verheule S, van Batenburg CA, Coenjaerts FE, Kirchhoff S, et al (1999). Cardiac conduction abnormalities in mice lacking the gap junction protein connexin40. J. Cardiovasc. Electrophysiol. 10: 1380-1389. Wirka RC, Gore S, Van Wagoner DR, Arking DE, et al (2011). A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation. Circ Arrhythm Electrophysiol 4: 87-93. Yao J, Ma YT, Huang Z, Liu F, et al (2010). Prevalence and relative risk factors of atrial fibrillation in Xinjiang adult population. Chin. J. Card. Arrhythm. 5: 392-396.