Y chromosome microdeletion

Varicocele and male infertility in Northeast China: Y chromosome microdeletion as an underlying cause

R. L. Dai, Hou, Y., Li, F. B., Yue, J. M., Xi, Q., and Liu, R. Z., Varicocele and male infertility in Northeast China: Y chromosome microdeletion as an underlying cause, vol. 14, pp. 6583-6590, 2015.

The prevalence of Y chromosome microdeletions among azoospermic, severe oligozoospermic, moderate oligozoospermic, and mild oligozoospermic patients with varicocele-related and idiopathic infertility shows conflicting data in Asian countries. We aimed to detect this frequency in Northeast China, and investigated spermatogenic defects whether associated with varicocele or Y chromosome microdeletions. All samples underwent a thorough physical examination, semen analysis, and PCR analyses for Y chromosome microdeletions.

Detection of Y chromosome microdeletions and mitochondrial DNA mutations in male infertility patients

A. I. Güney, Javadova, D., Kırac, D., Ulucan, K., Koc, G., Ergec, D., Tavukcu, H., and Tarcan, T., Detection of Y chromosome microdeletions and mitochondrial DNA mutations in male infertility patients, vol. 11, pp. 1039-1048, 2012.

Infertility affects about 10-15% of all couples attempting pregnancy with infertility attributed to the male partner in approximately half of the cases. Proposed causes of male infertility include sperm motility disturbances, Y chromosome microdeletions, chromosomal abnormalities, single gene mutations, and sperm mitochondrial DNA (mtDNA) rearrangements. To investigate the etiology of decreased sperm fertility and motility of sperm and to develop an appropriate therapeutic strategy, the molecular basis of these defects must be elucidated.

Genetic anomalies in patients with severe oligozoospermia and azoospermia in eastern Turkey: a prospective study

G. G. Ceylan, Ceylan, C., and Elyas, H., Genetic anomalies in patients with severe oligozoospermia and azoospermia in eastern Turkey: a prospective study, vol. 8, pp. 915-922, 2009.

Infertility is defined as the inability to conceive a child after one year of regular unprotected intercourse; it is a major health problem affecting about 10-15% of all couples. Infertility is due to a male factor in approximately 50% of cases. The human Y chromosome contains genes necessary for gonadal differentiation into a testis and genes for complete spermatogenesis. We examined the frequency and type of both chromosomal abnormalities and Y chromosome microdeletions in 90 patients with severe male factor infertility and 75 fertile control men.

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