Y chromosome microdeletion

Detection of Y chromosome microdeletions and mitochondrial DNA mutations in male infertility patients

A. I. Güney, Javadova, D., Kırac, D., Ulucan, K., Koc, G., Ergec, D., Tavukcu, H., and Tarcan, T., Detection of Y chromosome microdeletions and mitochondrial DNA mutations in male infertility patients, vol. 11, pp. 1039-1048, 2012.

Infertility affects about 10-15% of all couples attempting pregnancy with infertility attributed to the male partner in approximately half of the cases. Proposed causes of male infertility include sperm motility disturbances, Y chromosome microdeletions, chromosomal abnormalities, single gene mutations, and sperm mitochondrial DNA (mtDNA) rearrangements. To investigate the etiology of decreased sperm fertility and motility of sperm and to develop an appropriate therapeutic strategy, the molecular basis of these defects must be elucidated.

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