Y chromosome

Y-STR haplotype diversity and population data for Central Brazil: implications for environmental forensics and paternity testing

T. C. Vieira, Gigonzac, M. A. D., Silva, D. M., Rodovalho, R. G., Santos, G. S., and da Cruz, A. D., Y-STR haplotype diversity and population data for Central Brazil: implications for environmental forensics and paternity testing, vol. 13. pp. 3404-3410, 2014.

The central region of Brazil was colonized by internal migration of individuals of different origins, who contributed to the genetic diversity existing in this population. This study determined the allele frequencies and haplotype diversity of Y-STRs in Goiás State, Central Brazil, and compared the data obtained with a sample of the Brazilian population, consisting of individuals from the five geographical regions of Brazil. A total of 353 males were typed for 12 Y-chromosome short tandem repeat (Y-STR) markers.

Male infertility in Northeast China: molecular detection of Y chromosome microdeletions in azoospermic patients with Klinefelter's syndrome

H. - G. Zhang, Zhang, Z. - B., Wang, R. - X., Yu, Y., Yu, X. - W., Fadlalla, E., and Liu, R. - Z., Male infertility in Northeast China: molecular detection of Y chromosome microdeletions in azoospermic patients with Klinefelter's syndrome, vol. 12, pp. 4972-4980, 2013.

The prevalence of microdeletions of azoospermia factor (AZF) among azoospermic Klinefelter's syndrome (KFS) patients shows conflicting data. We aimed to detect this frequency in a Northeast Chinese population, and to investigate the possible association between AZF microdeletions and KFS by comparison with previous conflicting reports. Eighty men affected with KFS and a random healthy control group comprising 60 fertile men and women were recruited. AZF microdeletions were detected by multiplex polymerase chain reaction using 9 specific sequence-tagged sites.

Tracking microdeletions of the AZF region in a patrilineal line of infertile men

R. G. Rodovalho, Arruda, J. T., and Moura, K. K. V. O., Tracking microdeletions of the AZF region in a patrilineal line of infertile men, vol. 7, pp. 614-622, 2008.

Male infertility is considered to be a difficult-to-treat condition because it is not a single entity, but rather reflects a variety of different pathologic conditions, thus making it difficult to use a single treatment strategy. Structural alterations in the Y chromosome have been the principal factor responsible for male infertility. We examined 26 family members of 13 patients with male infertility who showed deletions in the AZF region. In family 1, the father and a brother did not show microdeletions.

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