XRCC3-Thr241Met

DNA repair gene polymorphisms and susceptibility to familial breast cancer in a group of patients from Campinas, Brazil

R. Mucha Dufloth, Costa, S., Schmitt, F., and Zeferino, L. Carlos, DNA repair gene polymorphisms and susceptibility to familial breast cancer in a group of patients from Campinas, Brazil, vol. 4, pp. 771-782, 2005.

Several studies have reported that the genes involved in DNA repair and in the maintenance of genome integrity play a crucial role in protecting against mutations that lead to cancer. Epidemiologic evidence has shown that the inheritance of genetic variants at one or more loci results in a reduced DNA repair capacity and in an increased risk of cancer.

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