XRCC1

Analyzing the association between XRCC1 c.1804C>A genetic variant and lung cancer susceptibility in the Chinese population

J. J. Jin, Wang, H. Q., Kuang, H. P., Kang, B. B., Liu, Y. H., Wang, J., Jin, J. J., Wang, H. Q., Kuang, H. P., Kang, B. B., Liu, Y. H., and Wang, J., Analyzing the association between XRCC1 c.1804C>A genetic variant and lung cancer susceptibility in the Chinese population, vol. 15, p. -, 2016.

Lung cancer is the most common cancer occurring worldwide. The human X-ray repair complementing group 1 (XRCC1) gene is one of the most important candidate genes that influence the susceptibility to lung cancer. The objective of this study was to analyze the potential association between the c.1804C>A genetic variant of XRCC1 and lung cancer susceptibility. A total of 703 subjects were recruited for this study. Genotyping of c.1804C>A genetic variant was performed using the created restriction site-polymerase chain reaction.

Association of XRCC1 gene polymorphisms and pancreatic cancer risk in a Chinese population

L. J. Wang, Wang, H. T., Wang, X. X., Wang, L. J., Wang, H. T., and Wang, X. X., Association of XRCC1 gene polymorphisms and pancreatic cancer risk in a Chinese population, vol. 15, p. -, 2016.

We conducted a case-control study to assess the role of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp gene polymorphisms in pancreatic cancer susceptibility in a Chinese population. A total of 152 patients diagnosed with pancreatic cancer and 264 control subjects were enrolled in this study between March 2012 and October 2014. XRCC1 Arg399Gln, Arg280His, and Arg194Trp were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method.

Genetic variability of XRCC1 influences the treatment outcome of gastric cancer

H. Q. Hu, Wang, F., Du, X., Zhao, X. Z., Jin, Z., Hou, M. X., Hu, H. Q., Wang, F., Du, X., Zhao, X. Z., Jin, Z., and Hou, M. X., Genetic variability of XRCC1 influences the treatment outcome of gastric cancer, vol. 15, p. -, 2016.

We aimed to investigate the role of XRCC1 codon 194 (Arg>Trp), 280 (Arg>His), and 399 (Arg>Gln) polymorphisms in response to chemotherapy and the overall survival of gastric cancer patients. A total of 172 patients were recruited for our study between January 2010 and March 2012. Genotyping of the three XRCC1 codons was carried out by restriction fragment length polymorphism polymerase chain reaction.

Association between the XRCC1 Arg399Gln polymorphism and risk of cervical carcinoma: a meta-analysis

D. Y. Liu, Liang, H. C., and Xiao, X. M., Association between the XRCC1 Arg399Gln polymorphism and risk of cervical carcinoma: a meta-analysis, vol. 14, pp. 9821-9828, 2015.

Numerous studies have evaluated the association between Arg399Gln polymorphism of DNA repair gene XRCC1 and cervical carcinoma risk. However, the specific association is still controversial. To assess the relationship between XRCC1 Arg399Gln polymorphism and cervical carcinoma, we conducted a comprehensive meta-analysis of 10 case-control studies with 2051 cervical carcinoma cases and 2919 controls.

Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer

J. Y. Liu, Li, L. R., and Liu, Q. M., Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer, vol. 14, pp. 10331-10337, 2015.

We investigated the association between the polymorphisms GSTP1 rs1695 and XRCC1 rs1799782 and rs25487 and the clinical outcome of patients with non-small cell lung cancer (NSCLC) receiving cisplatin-based chemotherapy. Genotyping of GSTP1 rs1695 and XRCC1 rs1799782, and rs25487 was conducted by polymerase chain reaction-restriction fragment length polymorphism analysis.

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