XPD751

Relationship between DNA repair gene XPD751 single-nucleotide polymorphisms and prognosis of colorectal cancer

Y. Dong, Liu, J. W., Gao, Y. J., Zhou, T., and Chen, Y. M., Relationship between DNA repair gene XPD751 single-nucleotide polymorphisms and prognosis of colorectal cancer, vol. 14, pp. 5390-5398, 2015.

We examined the relationships between single-nucleotide polymorphisms (SNPs) in the DNA repair gene XPD751 and the efficacy and time to disease progression (TTP) in colorectal cancer patients after platinum-based chemotherapy. Ninety-eight patients diagnosed with advanced colorectal cancer were subjected to oxaliplatin and 5-fluorouracil combination therapy. DNA was extracted from venous blood before chemotherapy. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to detect XPD751 SNPs.

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