Xenobiotics

Molecular cloning and cDNA characterization of Camelus dromedarius putative cytochrome P450s 1A, 2C, and 3A

H. M. Saeed, Alanazi, M. S., Shalaby, M. A., Alshahrani, O., Ataya, F. S., Pathan, A. A., and Abduljaleel, Z. A., Molecular cloning and cDNA characterization of Camelus dromedarius putative cytochrome P450s 1A, 2C, and 3A, vol. 13, pp. 2886-2905, 2014.

The domesticated one-humped Arabian camel, Camelus dromedarius, is one of the most important animals in the Arabian Peninsula. Most of its life, this animal is exposed to both intrinsic and extrinsic genotoxic factors that are known to cause gross metabolic alterations in many organisms. This study determined the full length coding sequence of 3 cytochrome P450s cDNAs; namely, CYP450 1A1, CYP450 2C and CYP450 3A using reverse transcription polymerase chain reaction. The C.

Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility

A. C. F. Finotti, Silva, R. C. P. Costa e, Bordin, B. M., Silva, C. T. X., and Moura, K. K. V. O., Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility, vol. 8, pp. 1093-1098, 2009.

Male infertility is a heterogeneous disorder, with vari­ous genetic and environmental factors that contribute to the impairment of spermatogenesis. Genetic causes are responsible for 60% of cases of idiopathic infertility. Polymorphisms of genes that encode detoxi­fying enzymes of phase II drug metabolism can modify their expres­sion or function, affecting the biotransformation of toxic compounds to which the male reproductive system is exposed.

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