Xenobiotics

Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility

A. C. F. Finotti, Silva, R. C. P. Costa e, Bordin, B. M., Silva, C. T. X., and Moura, K. K. V. O., Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility, vol. 8, pp. 1093-1098, 2009.

Male infertility is a heterogeneous disorder, with vari­ous genetic and environmental factors that contribute to the impairment of spermatogenesis. Genetic causes are responsible for 60% of cases of idiopathic infertility. Polymorphisms of genes that encode detoxi­fying enzymes of phase II drug metabolism can modify their expres­sion or function, affecting the biotransformation of toxic compounds to which the male reproductive system is exposed.

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