Wound healing

Role of adiponectin in adipose tissue wound healing

C. E. Jin, Xiao, L., Ge, Z. H., Zhan, X. B., and Zhou, H. X., Role of adiponectin in adipose tissue wound healing, vol. 14, pp. 8883-8891, 2015.

The purpose of this study was to investigate the mechanism behind adipose tissue wound healing (ATWH). The preadipocyte cell line 3T3-L1 was cultured and expression of adiponectin receptors (AdipoR1/2) was detected by immunohistochemistry and reverse transcription polymerase chain reaction. The concentration of adiponectin secreted at different cell densities was measured by enzyme-linked immunosorbent assay, while preadipocyte proliferation and migration were determined in vitro by MTT and wound closure assays. AdipoR1/2 were found to be expressed in 3T3-L1 preadipocytes.

Bioinformatic analysis of the effect of type II diabetes on skin wound healing

K. Ge, Wu, J. J., Qian, L., Wu, M. J., Wang, F. L., Xu, B., and Xie, T., Bioinformatic analysis of the effect of type II diabetes on skin wound healing, vol. 14, pp. 4802-4811, 2015.

We examined the relationship between type 2 diabetes and skin wound healing. GSE38396 was downloaded from the Gene Expression Omnibus database and preprocessed using the RMA func­tion of the Affy package. Differentially expressed genes (DEGs) were identified using the limma package, then DAVID was applied to per­form Gene Ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. MicroRNAs and their target genes were screened from the miRecords database and sub­jected to functional analysis.

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