Wnt/β-catenin

Wnt/β-catenin aids in regulating the proliferation of hepG2 cells mediated by thy-1

B. Q. Cheng, Jiang, Y., Zhu, Q., and Lin, W. G., Wnt/β-catenin aids in regulating the proliferation of hepG2 cells mediated by thy-1, vol. 13, pp. 5115-5127, 2014.

Cancer stem cells have been found to play important roles in carcinoma. Although thy-1 has been identified as a potential stem cell marker of liver cancer, whether the Wnt/β-catenin signaling pathway plays an important role in regulating hepatocarcinoma proliferation and apoptosis mediated by thy-1 remains unknown. Our results showed that high thy-1 expression caused hepG2 cells transfected with a pReceiver-M29/thy-1 eukaryotic expression vector to exhibit obvious heteromorphism, featuring double or multiple nuclei and weaker apoptosis.

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