Wistar rats

Effect of atorvastatin on diabetic rat endothelial cells and retinal lesions

M. C. Bi, Song, X. J., Shi, H., Xue, W. X., Xu, C. L., and Song, E., “Effect of atorvastatin on diabetic rat endothelial cells and retinal lesions”, vol. 14, pp. 5462-5467, 2015.

We investigated the effect of atorvastatin on vascular endothelial growth inhibitor (VEGI) expression in rats with diabetic retinopathy. Wistar rats were divided into a blank group and diabetic model group, which was further randomly divided into treatment and control groups. Rats in the treatment group received 10 mg/kg atorvastatin daily, while rats in the blank and control groups received normal saline. Rats were randomly euthanized at 3 or 6 months.

Cytotoxicity and mutagenicity of fluoxetine hydrochloride (Prozac), with or without vitamins A and C, in plant and animal model systems

E. Düsman, Almeida, I. V., Mariucci, R. G., Mantovani, M. S., and Vicentini, V. E. P., “Cytotoxicity and mutagenicity of fluoxetine hydrochloride (Prozac), with or without vitamins A and C, in plant and animal model systems”, vol. 13, pp. 578-589, 2014.

Fluoxetine, commonly known as Prozac, is the first representative of the so-called new generation of antidepressants that promise efficacy, with few side effects, against deep depression, nervous bulimia, and anxiety. As there is a growing number of people suffering from anxiety and depression; consequently, the use of fluoxetine is also increasing. Verifying absence of drug effects such as cytotoxicity or mutagenicity is of great importance. Certain vitamins, such as vitamin A (retinol, retinoids) and vitamin C (ascorbic acid) protect and are extremely active against mutagens.

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