In vivo

Evaluation of Hsp47 expression in heat-stressed rat myocardial cells in vitro and in vivo

A. Abdelnasir, Sun, J. R., Cheng, Y. F., Chen, H. B., Tang, S., Kemper, N., Hartung, J., and Bao, E. D., Evaluation of Hsp47 expression in heat-stressed rat myocardial cells in vitro and in vivo, vol. 13, pp. 10787-10802, 2014.

The aim of the present study was to identify the correlation between expression of heat shock protein 47 (Hsp47) and stress injury in heat-stressed myocardial cells and to compare variations in Hsp47 expression in rat myocardial cells exposed to different heat stress for varying periods in vitro and in vivo. Exposure to heat stress at 42°C resulted in similar induction patterns of the heart damage-related enzyme aspartate aminotransferase in the supernatants of H9c2 cells and in the serum of rats.

Evaluation of the mutagenicity and antimutagenicity of soy phytoestrogens using micronucleus and comet assays of the peripheral blood of mice

A. M. Niwa, Oliveira, R. J., and Mantovani, M. S., Evaluation of the mutagenicity and antimutagenicity of soy phytoestrogens using micronucleus and comet assays of the peripheral blood of mice, vol. 12, pp. 519-527, 2013.

Studies show that soy imparts many favorable properties in the human body, including the prevention of chronic diseases such as osteoporosis, heart disease, cancer, and diabetes. Soy is rich in isoflavones, and it is a candidate for the chemoprevention of diseases owing to its low toxicity. In this study, a soy phytoestrogen (with high levels of the isoflavones genistin and daidzein) was tested in mice to investigate its mutagenicity and genotoxicity using micronucleus and comet assays of mouse peripheral blood.

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