Candida albicans GRX2, encoding a putative glutaredoxin, is required for virulence in amurine model
, “Candida albicans GRX2, encoding a putative glutaredoxin, is required for virulence in amurine model”, vol. 6, pp. 1051-1063, 2007.
Resistance of Candida albicans to reactive oxygen species is thought to enhance its virulence in mammalian hosts. Genes such as SOD1, which encodes the anti-oxidant, superoxide dismutase, are known virulence factors. We disrupted the gene GRX2, which encodes a putative glutathione reductase (glutaredoxin) in C. albicans, and we compared the mutant with an sod1Δmutant. In vitro, the grx2Δstrain, but not the sod1Δstrain, was defective in hypha formation.
