VEGF

Association between angiogenic growth factor genetic polymorphisms and the risk of osteosarcoma

H. F. Zhang, Yan, J. P., Zhuang, Y. S., and Han, G. Q., “Association between angiogenic growth factor genetic polymorphisms and the risk of osteosarcoma”, vol. 14, pp. 10524-10529, 2015.

The aim of this study was to assess the role of the VEGF -2578C/A, +936C/T, and -460T/C gene polymorphisms in the development of osteosarcoma. A total of 182 patients with osteosarcoma and 182 age- and gender-matched healthy controls were enrolled into our study during January 2011 and December 2013. Genotype frequencies of the VEGF -2578C/A and -460T/C alleles in controls were found to be within the parameters of Hardy-Weinberg equilibrium, but the genotype frequencies of +936C/T alleles were not.

Inhibition of vascular endothelial growth factor A expression in mouse granulosa cells by lentivector-mediated RNAi

N. Ally, Zou, X. L., Jiang, B. C., Qin, L., Zhai, L., Xiao, P., and Liu, H. L., “Inhibition of vascular endothelial growth factor A expression in mouse granulosa cells by lentivector-mediated RNAi”, vol. 11, pp. 4019-4033, 2012.

Vascular endothelial growth factor (VEGF) has been found responsible for the induction of proliferation and differentiation in granulosa cells. We constructed four short hairpin RNA (shRNA) expression plasmids targeting the mouse VEGFA gene, and examined their effect on VEGF expression in mouse granulosa cells (MGC) in vitro. Four different shRNA oligonucleotides targeting the coding sequence of mouse VEGFA mRNA and one negative control (shNC) were designed and cloned into a pGPU6/GFP/Neo siRNA expression vector, and transiently transfected into MGC.

Vascular endothelial growth factor gene 1154 G/A, 2578 C/A, 460 C/T, 936 C/T polymorphisms and association with recurrent pregnancy losses

H. Şamlı, Demir, B. Ç., Özgöz, A., Atalay, M. A., and Uncu, G., “Vascular endothelial growth factor gene 1154 G/A, 2578 C/A, 460 C/T, 936 C/T polymorphisms and association with recurrent pregnancy losses”, vol. 11, pp. 4739-4745, 2012.

Vascular endothelial growth factor (VEGF) regulates endothelial cell proliferation, migration and differentiation. VEGF plays a critical role in angiogenesis during placenta formation. We investigated whether VEGF gene polymorphisms are associated with recurrent pregnancy loss. Thirty-eight women with recurrent pregnancy loss and 30 control women with live-born children were recruited from 2010 to 2011 in the region of Bursa, Turkey. VEGF gene polymorphisms were assessed with PCR-RFLP analysis of DNA samples obtained from leukocytes.

Vascular endothelial growth factor gene polymorphisms contribute to the risk of endometriosis: an updated systematic review and meta-analysis of 14 case-control studies

Y. Z. Li, Wang, L. J., Li, X., Li, S. L., Wang, J. L., Wu, Z. H., Gong, L., and Zhang, X. D., “Vascular endothelial growth factor gene polymorphisms contribute to the risk of endometriosis: an updated systematic review and meta-analysis of 14 case-control studies”, vol. 12, pp. 1035-1044, 2013.

Endometriosis is a chronic gynecological disease defined as the presence of the endometrium outside the uterine cavity. Endometriosis is a multifactorial and polygenic disease in which angiogenesis may be implicated. Angiogenesis is under the control of numerous inducers, including vascular endothelial growth factor (VEGF). Many studies have reported that VEGF plays a role in the progression of the disease, but individually published studies showed inconclusive results. We investigated the association between VEGF polymorphisms and the susceptibility to endometriosis.

Vascular endothelial growth factor gene polymorphisms and colorectal cancer risk: a meta-analysis

L. P. Zhou, Luan, H., Dong, X. H., Jin, G. J., Man, D. L., and Shang, H., “Vascular endothelial growth factor gene polymorphisms and colorectal cancer risk: a meta-analysis”, vol. 10, pp. 3674-3688, 2011.

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in a number of pathologic processes, including angiogenesis, tumor growth and metastasis. Polymorphisms of the VEGF gene have been associated with susceptibility to colorectal cancer (CRC). However, the specific association still remains controversial. We made a meta-analysis of the association between VEGF gene polymorphisms and CRC risk. Only eight case-control studies were retrieved, with a total of 2337 CRC patients and 2032 healthy controls.

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