Effect of polymorphisms of vascular endothelial growth factor on prognosis in osteosarcoma patients
, “Effect of polymorphisms of vascular endothelial growth factor on prognosis in osteosarcoma patients”, vol. 14, pp. 4354-4360, 2015.
We investigated the association between vascular endothelial growth factor (VEGF) gene +1612G/A, -634C/G, and +936G/C and the clinical outcome of osteosarcoma. Genomic DNA was isolated from blood samples, and 3 VEGF gene polymorphisms (+1612G/A, -634C/G, and +936G/C) were analyzed using polymerase chain reaction-restriction fragment length polymorphism. Of the 194 patients, 82 patients (42.27%) showed a good response to chemotherapy, while 73 (37.63%) died during the follow-up period.
