Vascular endothelial growth factor A (VEGF-A)

Association of novel single-nucleotide polymorphisms of the vascular endothelial growth factor-A gene with high-altitude adaptation in yak (Bos grunniens)

X. Y. Wu, Liang, C. N., Ding, X. Z., Guo, X., Bao, P. J., Chu, M., Liu, W. B., and Yan, P., Association of novel single-nucleotide polymorphisms of the vascular endothelial growth factor-A gene with high-altitude adaptation in yak (Bos grunniens), vol. 12, pp. 5506-5515, 2013.

Vascular endothelial growth factor-A gene (VEGF-A) is a key regulator of angiogenesis and an endothelial cell mitogen that plays an important role in high-altitude adaptation. In this study, we detected 2 novel single-nucleotide polymorphisms (SNPs) of VEGF-A by screening for genetic variation in 700 individuals of 3 domestic Chinese yak breeds - namely Gannan (GN), Datong (DT), and Tianzhu white (TZW) - using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing techniques.

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