Vascular endothelial growth factor

Correlation of tumor relapse and elevated expression of survivin and vascular endothelial growth factor in superficial bladder transitional cell carcinoma

Y. W. Sun, Xuan, Q., Shu, Q. A., Wu, S. S., Chen, H., Xiao, J., Xiang, P., Zhu, Y. P., Wang, F. L., and Zhao, S. T., Correlation of tumor relapse and elevated expression of survivin and vascular endothelial growth factor in superficial bladder transitional cell carcinoma, vol. 12, pp. 1045-1053, 2013.

Survivin and vascular endothelial growth factor (VEGF) are newly discovered tumor markers closely correlated with bladder cancer. We analyzed the expression of survivin and VEGF in paraffin-embedded tumor tissues from 78 patients with bladder transitional cell carcinoma (BTCC) using an immunohistochemistry method. Normal bladder mucosae from 10 non-BTCC cases were also included as a control group. All patients were closely followed up for tumor recurrence after undergoing transurethral resection of bladder tumor procedures.

Vascular endothelial growth factor +936C/T polymorphism and cancer risk in Asians: a meta-analysis

X. L. Liu, Yang, Q. F., and Kong, B. H., Vascular endothelial growth factor +936C/T polymorphism and cancer risk in Asians: a meta-analysis, vol. 12, pp. 1924-1933, 2013.

Vascular endothelial growth factor (VEGF), the most important regulator of angiogenesis and vascular permeability, is involved in various steps of carcinogenesis. The +936C/T polymorphism of the VEGF gene has been reported to affect the VEGF protein level and to be related to the susceptibility of cancer. However, the results of published studies, as well as the subsequent meta-analyses, remain contradictory. We investigated the association between VEGF +936C/T polymorphism and cancer risk in the Asian population.

Association between VEGF and eNOS gene polymorphisms and lumbar disc degeneration in a young Korean population

I. B. Han, Ropper, A. E., Teng, Y. D., Shin, D. A., Jeon, Y. J., Park, H. M., Shin, D. E., Park, Y. S., Kim, K. N., and Kim, N. - K., Association between VEGF and eNOS gene polymorphisms and lumbar disc degeneration in a young Korean population, vol. 12, pp. 2294-2305, 2013.

Disturbances in blood flow to intervertebral discs (IVD) play an important role in IVD degeneration. Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) are extremely important angiogenic factors for vasodilation and neovascularization. We investigated the relationship between single nucleotide polymorphisms (SNPs) of the VEGF and eNOS genes and genetic susceptibility to lumbar IVD degeneration in a young adult Korean population.

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