Vascular endothelial growth factor

Effects of VEGF/VEGFR/K-ras signaling pathways on miRNA21 levels in hepatocellular carcinoma tissues in rats

J. Z. Gao, Wang, Y. L., Li, J., and Wei, L. X., Effects of VEGF/VEGFR/K-ras signaling pathways on miRNA21 levels in hepatocellular carcinoma tissues in rats, vol. 14, pp. 671-679, 2015.

The aim of this study was to investigate the effects of the vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)/K-ras signaling pathways on miRNA21 levels in hepatocellular carcinoma tissues in rats. Eighteen male Sprague-Dawley rats were randomly divided into normal control, model, and VEGF blocking agent groups (N = 6/group).

Effects of autologous SCF- and G-CSF-mobilized bone marrow stem cells on hypoxia-inducible factor-1 in rats with ischemia-reperfusion renal injury

L. Y. Bi, Zhao, D. A., Yang, D. S., Guo, J. G., Liang, B., Zhang, R. X., Zhao, J. L., Bai, H. T., and Li, S. J., Effects of autologous SCF- and G-CSF-mobilized bone marrow stem cells on hypoxia-inducible factor-1 in rats with ischemia-reperfusion renal injury, vol. 14, pp. 4102-4112, 2015.

To explore the mechanism whereby stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) jointly mobilize bone marrow stem cells (BMSCs) and promote kidney repair, male Sprague-Dawley rats were randomly assigned into 4 groups. In the treatment control group, rats were administered SCF (200 μg·kg-1·day-1) and G-CSF (50 μg·kg-1·day-1) for 5 days. In the treatment group, RIRI models were established, and 6 h later, SCF (200 μg·kg-1·day-1) and G-CSF (50 μg·kg-1·day-1) were administered for 5 days.

Effect of atorvastatin on diabetic rat endothelial cells and retinal lesions

M. C. Bi, Song, X. J., Shi, H., Xue, W. X., Xu, C. L., and Song, E., Effect of atorvastatin on diabetic rat endothelial cells and retinal lesions, vol. 14, pp. 5462-5467, 2015.

We investigated the effect of atorvastatin on vascular endothelial growth inhibitor (VEGI) expression in rats with diabetic retinopathy. Wistar rats were divided into a blank group and diabetic model group, which was further randomly divided into treatment and control groups. Rats in the treatment group received 10 mg/kg atorvastatin daily, while rats in the blank and control groups received normal saline. Rats were randomly euthanized at 3 or 6 months.

Effects of VEGF suppression by small hairpin RNA interference combined with radiotherapy on the growth of cervical cancer

L. Qi, Xing, L. N., Wei, X., and Song, S. G., Effects of VEGF suppression by small hairpin RNA interference combined with radiotherapy on the growth of cervical cancer, vol. 13, pp. 5094-5106, 2014.

This study aimed to investigate the inhibition of vascular endothelial growth factor (VEGF) by small hairpin RNA (shRNA) interference combined with radiotherapy on the growth of cervical cancer SiHa cell xenografts in nude mice. The effective pVEGF-shRNA plasmid was screened by reverse transcription-polymerase chain reaction (RT-PCR), and the cell apoptosis rate was estimated by flow cytometry. A nude mouse cervical xenograft model was established and all models were divided into four groups: blank control, VEGF shRNA, radiotherapy, and combined treatment.

Association between EGF and VEGF functional polymorphisms and sporadic colorectal cancer in the Malaysian population

T. P. Lau, Roslani, A. C., Lian, L. H., Lee, P. C., Hilmi, I., Goh, K. L., and Chua, K. H., Association between EGF and VEGF functional polymorphisms and sporadic colorectal cancer in the Malaysian population, vol. 13, pp. 5555-5561, 2014.

Growth factors are polypeptides that are critical for the initiation, progression, and metastasis of cancer. Most tumor cells are capable of synthesizing particular growth factors leading to constitutive pathway activation in these cells through autocrine signaling. Epidermal growth factor (EGF) is a potent mitogenic peptide that exerts direct effects on the proliferation and differentiation of tumor cells in carcinogenesis.

Significance of the expression of integrin β1, VEGF and MVD in hypopharyngeal squamous cell carcinoma

Y. M. Hong, Gan, W. G., and Xu, Z. H., Significance of the expression of integrin β1, VEGF and MVD in hypopharyngeal squamous cell carcinoma, vol. 13, pp. 6455-6465, 2014.

This study aimed to determine the expression of integrin β1 and vascular endothelial growth factor (VEGF) and microvascular density (MVD) by CD105 staining in hypopharyngeal squamous cell carcinoma to determine their association with clinicopathologic characteristics, and to determine their role and the effects of their interactions in the development and progression of hypopharyngeal squamous cell carcinomas. The expression of integrin β1 and VEGF and MVD in hypopharyngeal squamous cell carcinomas and normal hypopharyngeal tissues were evaluated using immunohistochemistry.

Use of bone mesenchymal stem cells to treat rats with acute liver failure

S. F. Yuan, Jiang, T., Sun, L. H., Zheng, R. J., Cao, G. Q., Ahat, N. Z., and Zhang, Y. X., Use of bone mesenchymal stem cells to treat rats with acute liver failure, vol. 13, pp. 6962-6980, 2014.

This study aimed to isolate mesenchymal stem cells from bone mesenchymal stem cells (BMSCs), determine their therapeutic potential for treating rats with acute liver failure (ALF), further explore the factors that induce liver failure mechanisms, and elucidate the role of bone marrow stem cell therapy and BMSCs on liver homing. We found that differentiation potential was present in BMSCs expressing high levels of CD29 and CD90.

Association between metabolic syndrome and vascular endothelium dysfunction in children and adolescents

Y. Wei, Liu, G. L., Yang, J. Y., Zheng, R. X., Jiang, L. H., Li, Y. P., and Gao, F. F., Association between metabolic syndrome and vascular endothelium dysfunction in children and adolescents, vol. 13, pp. 8671-8678, 2014.

We aimed at investigating the association between metabolic syndrome (MS) and vascular endothelial cell dysfunction (ECD) in children and adolescents. Sixty children (30 obese children and 30 children with MS) were included in this retrospective analysis. Thirty healthy subjects were randomly selected as the control group. A series of indices/biomarkers known to be related to MS/ECD were determined using ELISA. Correlations between the variables measured were analyzed. Compared with the control group, PAI-1, vWF, VE-cad, TM, and VEGF were significantly increased in the MS group (P

Polymorphisms of vascular endothelial growth factor on prognosis in hepatocellular carcinoma patients receiving transcatheter arterial chemoembolization treatment

J. Song, Wang, L. Z., Li, X., Jiang, T. P., An, T. Z., Xu, M., Wu, X. P., and Zhou, S., Polymorphisms of vascular endothelial growth factor on prognosis in hepatocellular carcinoma patients receiving transcatheter arterial chemoembolization treatment, vol. 13, pp. 8946-8953, 2014.

We conducted a cohort study to investigate the prognostic significance of vascular endothelial growth factor (VEGF) polymorphisms in hepatocellular carcinoma (HCC) patients after transcatheter arterial chemoembolization (TACE). In total, 156 patients with histologically confirmed HCC within 2 months were collected from January 2007 to January 2008. The genotypes of VEGF-2578C/A, -1154G/A, -634C/G, and -1498T/C were determined from blood extracted using a blood kit on a 384-well plate. The survival rate at 5 years was 55.47%.

Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway

J. Zhang and Ma, W. Y., Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway, vol. 13, pp. 9324-9335, 2014.

Decades of research have provided the data to confirm the hypothesis that there is bidirectional communication between the central nervous system and the immune system in psoriasis pathogenesis, but the contribution of the cutaneous neural system remains underexplored. In this study, we evaluated the molecular mechanisms by which nerve growth factor (NGF) regulates hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) production. The mRNA and protein levels of VEGF secretion from HaCaT cells by NGF were increased in a concentration-dependent manner.

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